Cas no 51811-82-6 (Giemsa stain)

Giemsa stain is a classical histological and cytological dye widely used for staining blood films, bone marrow, and other biological specimens. Composed of methylene blue, eosin, and azure B, it differentially stains cellular components, enabling clear visualization of nuclei, cytoplasm, and microorganisms such as malaria parasites and bacteria. Its key advantages include high specificity for chromatin and cytoplasmic granules, consistent staining reproducibility, and compatibility with both light and fluorescence microscopy. Giemsa stain is particularly valued in hematology, parasitology, and cytogenetics for its ability to highlight morphological details, aiding in accurate diagnosis and research applications. The stain is typically prepared in methanol or buffer solutions for optimal performance.

Giemsa stain structure

Product Name:Giemsa stain

CAS No:51811-82-6

MF:C₁₄H₁₄ClN₃S

MW:291.799060344696

MDL:MFCD00081642

CID:56099

PubChem ID:24847458

Update Time:2025-05-20

Giemsa stain Chemical and Physical Properties

Names and Identifiers

- Giemsa Stain
- AZURE MIXTURE SICC GIEMSA STAIN
- AZUR EOSIN METHYLENE-BLUE
- AZURE EOSIN METHYLENE BLUE
- EOSIN AZURE GIEMSA
- EOSIN METHYLENE BLUE COMPOUND
- LEISHMAN'S STAINING SOLUTION
- GIEMSA BLOOD STAIN
- GIEMSA BLOOD STAINING SOLUTION
- GiemsaStain,highpuritybiologicalstain,pure25GR
- GiemsaStain,highpuritybiologicalstain,pure5GR
- Azure eosin methylene blue,Giemsa
- GIEMSA BUFFER
- GIEMSA L
- GIEMSA L STAIN
- GIEMSA R
- GIEMSA STAIN L
- GIEMSA STAIN R
- Giemsa Stain, high purity biological stain, pure
- GieMsa Stain, pure, high purity biological stain
- Giemsa Stain,high purity biological stain
- GieMsa's stai
- GIEMSA'S STAIN
- GieMsa-Solution
- Giemse Stain
- 3-(Dimethylamino)-7-aminophenothiazin-5-ium chloride
- AZURE A
- Dimethylthionine
- 3-Amino-7-(dimethylamino)phenothiazin-5-ium chloride
- Azur A
- N,N-Dimethylthionine
- Methylene Azure A
- C.I. 52005
- Giemsa solution
- 3-Amino-7-dimethylaminophenazathionium chloride
- Phenothiazin-5-ium, 3-amino-7-(dimethylamino)-, chloride
- asym-Dimethyl-3,7-diaminophenazathionium chloride
- 3-Amino-7-dimethylaminophenothiazin-5-ium chloride
- M731V243EF
- P
- BDBM50055937
- CHEMBL1091115
- Phenothiazin-5-ium, 3-amino-7-(dimethylamino)-, chloride (1:1)
- CCRIS 9315
- 3-AMINO-7-(DIMETHYLAMINO)PHENOTHIAZIN-5-IUM CHORIDE
- CHEBI:87637
- MFCD00012112
- SCHEMBL137066
- Sinitest
- Diagnex Blue
- giemsa-stain
- NS00042981
- EINECS 208-510-7
- 51811-82-6
- Mancha Giemsa
- N,N- Dimethylthionine
- AZURE A [MI]
- F72133
- MS-24168
- HY-D0947
- Macchia di Giemsa
- Azure A chloride
- CS-0022121
- Tincion de Giemsa
- NSC-326661
- FT-0622538
- UNII-M731V243EF
- (7-aminophenothiazin-3-ylidene)-dimethylazanium;chloride
- NSC326661
- AKOS015916263
- 8050-34-8
- EINECS 263-491-2
- 7-AMINO-N,N-DIMETHYL-3H-PHENOTHIAZIN-3-IMINIUM CHLORIDE
- CS-0022125
- Azuresin
- CI-52005
- n-(7-amino-3h-phenothiazin-3-ylidene)-n-methylmethanaminium chloride
- Azuresin [BAN:NF]
- 62298-43-5
- Fast Giemsa Stain Kit
- NSC 374111
- Azure A (Technical Grade)
- Azure A (C.I. 52005)
- Azure A chloride, certified by the Biological Stain Commission, Dye content 70 %
- AKOS024356709
- Azure A (chloride)
- DTXSID2040157
- Azure A eosinate
- AKOS024306943
- Azure A chloride, Dye content >=70 %
- FT-0626691
- 3-Amino-7-(dimethylamino)phenothiazin-5-ium chloride (1:1)
- 143629-25-8
- Teinture de Giemsa
- EINECS 257-438-2
- 531-53-3
- NSC 326661
- AMY22390
- Azure A chloride, certified by the Biological Stain Commission
- A901233
- CHEMBL3330735
- 3-Amino-7-(dimethylamino)phenothiazin-5-ium, salt with 2',4',5',7'-tetrabromo-3',6'-dihydroxyspiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one (2:1)
- Q4833095
- METHYLTHIONINIUM CHLORIDE HYDRATE IMPURITY B [EP IMPURITY]
- HY-D0944
- AZURE A CARBACRYLIC RESIN
- METHYLENE BLUE IMPURITY B
- 70%,for biological dyeing experiment
- DA-71257
- DA-61459
- 7-amino-N,N-dimethylphenothiazin-3-iminium chloride
- 7-(DIMETHYLAMINO)PHENOTHIAZIN-3-IMINIUM CHLORIDE
- PGWTYMLATMNCCZ-UHFFFAOYSA-M
- DA-61460
- G73505
- Giemsa stain
- MDL： MFCD00081642
- Inchi： 1S/C14H13N3S.ClH/c1-17(2)10-4-6-12-14(8-10)18-13-7-9(15)3-5-11(13)16-12;/h3-8,15H,1-2H3;1H
- InChI Key： NALREUIWICQLPS-UHFFFAOYSA-N
- SMILES： [Cl-].S1C2C=C(C=CC=2N=C2C=C/C(/C=C12)=[N+](/C)\C)N

Computed Properties

Exact Mass: 291.06000
Monoisotopic Mass: 291.06
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 4
Heavy Atom Count: 19
Rotatable Bond Count: 0
Complexity: 483
Covalently-Bonded Unit Count: 2
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count : 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Topological Polar Surface Area: 66.7

Experimental Properties

Color/Form: Not available
Density: 0.99
Melting Point: 300?°C (lit.)
Boiling Point: No data available
Flash Point: Degrees Fahrenheit:48.2°F
Degrees Celsius:9°C
Solubility: ethanol: 1?mg/mL
Water Partition Coefficient: Insoluble in water (<0.1%), methanol (5.8 mg/L), and ethanol.
PSA: 70.39000
LogP: 0.96400
Sensitiveness: Sensitive to humidity
Solubility: Not available
Vapor Pressure: No data available

Giemsa stain Security Information

Symbol:
Signal Word：Danger
Hazard Statement： H301,H311,H318,H331,H370
Warning Statement： P260,P280,P301+P310,P305,P351,P338,P311
Hazardous Material transportation number：UN 1230 3/PG 2
WGK Germany：3
Hazard Category Code： 22-41
Safety Instruction： S7-S16-S36/37-S45-S39-S26
FLUKA BRAND F CODES：12
Hazardous Material Identification：
TSCA：Yes
Risk Phrases：R41
Safety Term：S26;S39
Storage Condition：Sealed storage.

Giemsa stain Customs Data

HS CODE：32129000

Giemsa stain Pricemore >>

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Giemsa stain Suppliers

Suzhou Senfeida Chemical Co., Ltd

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(CAS:51811-82-6)Giemsa stain

Order Number:sfd2686

Stock Status:in Stock

Quantity:200kg

Purity:99.9%

Pricing Information Last Updated:Friday, 19 July 2024 14:33

Price ($):discuss personally

Email:[email protected]

Product Official Link

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Additional information on Giemsa stain

Giemsa Stain: A Comprehensive Overview

The Giemsa Stain (CAS No. 51811-82-6) is a widely used histological staining technique that has revolutionized the field of microscopy and diagnostic pathology. This staining method, which utilizes a mixture of methylene blue and eosin, is particularly effective in differentiating various cellular components, such as DNA, RNA, and proteins. The Giemsa Stain has been a cornerstone in medical diagnostics, enabling researchers and clinicians to visualize cellular structures with exceptional clarity.

Historically, the Giemsa Stain was developed in the early 20th century by Dr. Walter Giemsa, a German pathologist. Its formulation was initially intended for the staining of blood smears to identify parasitic infections, such as malaria. Over time, its applications expanded to include cytogenetics, hematology, and microbiology. The Giemsa Stain is now a standard tool in laboratories worldwide due to its versatility and reliability.

Recent advancements in microscopy techniques have further enhanced the utility of the Giemsa Stain. For instance, the integration of digital imaging systems has allowed for more precise quantification of stained cells. This has been particularly beneficial in research areas such as cancer diagnostics, where accurate cell counting is critical. Additionally, studies have shown that the Giemsa Stain can be optimized for use with automated staining systems, reducing human error and improving throughput in high-volume laboratories.

One of the key advantages of the Giemsa Stain is its ability to differentiate between various types of cells based on their chromatin content. This property makes it invaluable in cytogenetic studies, where it is used to identify chromosomal abnormalities associated with genetic disorders. Recent research has also explored the use of modified Giemsa Stain protocols to improve sensitivity in detecting rare cell populations, such as circulating tumor cells in peripheral blood.

In terms of chemical composition, the Giemsa Stain primarily consists of methylene blue and eosin Y. These dyes interact with cellular components through specific binding mechanisms: methylene blue stains nucleic acids (DNA and RNA) due to its affinity for negatively charged phosphate groups, while eosin Y binds to proteins rich in basic amino acids. The balance between these two dyes ensures a high degree of specificity and contrast in stained samples.

Modern applications of the Giemsa Stain extend beyond traditional microscopy into advanced imaging techniques such as fluorescence microscopy and confocal laser scanning microscopy (CLSM). Researchers have developed fluorescence-labeled versions of the Giemsa Stain, enabling real-time visualization of cellular processes at a molecular level. These innovations have opened new avenues for studying dynamic cellular events, such as mitosis and apoptosis.

Despite its widespread use, there are ongoing efforts to improve the performance of the Giemsa Stain further. For example, recent studies have focused on enhancing its stability under varying pH conditions and optimizing its compatibility with fixation agents like formaldehyde. These modifications aim to ensure consistent staining results across different laboratory settings.

In conclusion, the Giemsa Stain (CAS No. 51811-82-6) remains an indispensable tool in medical research and diagnostics. Its ability to provide detailed cellular insights has been instrumental in advancing our understanding of various diseases and biological processes. As technology continues to evolve, so too will the applications and capabilities of this versatile staining method.

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