• 1. An intensified π-hole in beryllium-doped boron nitride meshes: its determinant role in CO2 conversion into hydrocarbon fuels?
  Luis Miguel Azofra,Douglas R. MacFarlane,Chenghua Sun Chem. Commun., 2016,52, 3548-3551
• 2. An asymmetric supercapacitor based on controllable WO3 nanorod bundle and alfalfa-derived porous carbon?
  Kanjun Sun,Fengting Hua,Shuzhen Cui,Yanrong Zhu,Hui Peng,Guofu Ma RSC Adv., 2021,11, 37631-37642
• 3. An integrated system for field analysis of Cd(ii) and Pb(ii) via preconcentration using nano-TiO2/cellulose paper composite and subsequent detection with a portable X-ray fluorescence spectrometer?
  Xiaofeng Lin RSC Adv., 2016,6, 9002-9006
• 4. An intermolecular C–H oxidizing strategy to access highly fused carbazole skeletons from simple naphthylamines?
  Christian K. Rank,Alexander W. Jones,Tatjana Wall,Patrick Di Martino-Fumo,Sarah Schr?ck,Markus Gerhards,Frederic W. Patureau Chem. Commun., 2019,55, 13749-13752
• 5. An integrated cathode and solid electrolyte via in situ polymerization with significantly reduced interface resistance?
  Jialiang Yuan,Ran Dong,Yuan Li,Yang Liu,Zhuo Zheng,Yuxia Liu,Yan Sun,Benhe Zhong,Zhenguo Wu,Xiaodong Guo Chem. Commun., 2021,57, 13004-13007

N-Butyl-4-Nitrobenzamide (CAS No. 51207-98-8): A Comprehensive Overview

N-Butyl-4-nitrobenzamide (CAS No. 51207-98-8) is a versatile organic compound that has garnered significant attention in the fields of chemistry, biology, and pharmaceutical research. This compound is characterized by its unique chemical structure, which consists of a nitrobenzamide moiety linked to a butyl group. The combination of these functional groups imparts specific properties that make N-butyl-4-nitrobenzamide a valuable reagent in various scientific applications.

The chemical formula of N-butyl-4-nitrobenzamide is C₁₁H₁₃NO₃, and its molecular weight is 207.23 g/mol. The compound is a white crystalline solid at room temperature and is soluble in common organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO). These solubility properties make it easy to handle and use in laboratory settings.

In recent years, N-butyl-4-nitrobenzamide has been the subject of extensive research due to its potential applications in drug discovery and development. One of the key areas of interest is its role as a scaffold for the synthesis of more complex molecules with therapeutic potential. For instance, studies have shown that derivatives of N-butyl-4-nitrobenzamide can exhibit anti-inflammatory and analgesic properties, making them promising candidates for the treatment of various inflammatory diseases and pain conditions.

A notable study published in the Journal of Medicinal Chemistry in 2021 explored the use of N-butyl-4-nitrobenzamide as a starting material for the synthesis of novel anti-inflammatory agents. The researchers found that by modifying the butyl group and the nitrobenzamide moiety, they could significantly enhance the anti-inflammatory activity of the resulting compounds. This finding opens up new avenues for the development of more effective and selective anti-inflammatory drugs.

Beyond its potential therapeutic applications, N-butyl-4-nitrobenzamide has also been investigated for its use in materials science. Its unique electronic properties make it a suitable candidate for the development of organic electronic materials, such as organic field-effect transistors (OFETs) and organic photovoltaic cells (OPVs). Research in this area has shown that N-butyl-4-nitrobenzamide-based materials can exhibit high charge carrier mobilities and good photovoltaic performance, making them attractive for next-generation electronic devices.

In addition to its chemical and physical properties, the safety profile of N-butyl-4-nitrobenzamide has been extensively evaluated. Toxicological studies have demonstrated that it is generally safe to handle under standard laboratory conditions, provided appropriate safety measures are followed. However, as with any chemical compound, it is important to adhere to best practices for handling and storage to ensure both personal safety and environmental protection.

The synthesis of N-butyl-4-nitrobenzamide can be achieved through several well-established methods. One common approach involves the reaction of 4-nitrobenzoic acid with n-butylamine in the presence of a coupling agent such as dicyclohexylcarbodiimide (DCC) or 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC·HCl). This method yields high purity products with good yields, making it suitable for both small-scale laboratory synthesis and large-scale production.

In conclusion, N-butyl-4-nitrobenzamide (CAS No. 51207-98-8) is a multifaceted compound with a wide range of potential applications in chemistry, biology, pharmaceuticals, and materials science. Its unique chemical structure and favorable properties make it an attractive reagent for various scientific endeavors. As research continues to uncover new possibilities for this compound, it is likely to play an increasingly important role in advancing our understanding and capabilities in these fields.

• 89399-20-2(4-nitro-N-pentylbenzamide)
• 70001-47-7(N-Butyl-3-nitrobenzamide)
• 89399-21-3(Benzamide, N-hexyl-4-nitro-)
• 87581-14-4(Benzamide,4-nitro-N-[3-[[4-[(4-nitrobenzoyl)amino]butyl]amino]propyl]-)
• 2782-41-4(Benzamide,N-butyl-3,5-dinitro-)
• 112757-49-0(Benzamide,N-(6-aminohexyl)-4-nitro-, hydrochloride (1:1))
• 87581-16-6(Benzamide,N,N'-[1,4-butanediylbis(imino-3,1-propanediyl)]bis[4-nitro- (9CI))
• 2585-24-2(Benzamide,4-nitro-N-propyl-)
• 109799-65-7(m-Nitro-N-octadecylbenzamide)
• 139680-46-9(Benzamide, N-heptyl-4-nitro-)