• 1. Dissolved oxygen sensor based on fluorescence quenching of oxygen-sensitive ruthenium complexes immobilized in sol–gel-derived porous silica coatings
  Analyst, 1996,121, 785-788
• 2. Evolution study of photo-synthesized gold nanoparticles by spectral deconvolution model: a quantitative approach
  Chung-Sung Yang,Mong-Shian Shih,Fang-Yi Chang New J. Chem., 2006,30, 729-735
• 3. Dissolution of cork biopolymers in biocompatible ionic liquids
  Helga Garcia,Rui Ferreira,Marija Petkovic,Jamie L. Ferguson,Maria C. Leit?o,H. Q. Nimal Gunaratne,Luís Paulo N. Rebelo Green Chem., 2010,12, 367-369
• 4. Examination of ammonia–poly(pyrrole) interactions by piezoelectric and conductivity measurements
  Analyst, 1991,116, 1125-1130
• 5. Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications?
  Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932

Introduction to m-Nitro-N-octadecylbenzamide (CAS No. 109799-65-7)

m-Nitro-N-octadecylbenzamide (CAS No. 109799-65-7) is a specialized organic compound that has garnered attention in various scientific and industrial applications due to its unique chemical properties and functional groups. This compound, also referred to as m-nitro-octadecylbenzamide, belongs to the class of benzamides, which are derivatives of benzene carboxylic acid with an amide group attached. The presence of the nitro group at the meta position and the long alkyl chain (octadecyl) makes it a versatile molecule with potential applications in materials science, pharmaceuticals, and advanced chemical synthesis.

The molecular structure of m-nitro-N-octadecylbenzamide consists of a benzene ring substituted with a nitro group (-NO?) at the meta position and an amide group (-CONH-) connected to an octadecyl chain (C??H??). This combination imparts the compound with both aromatic stability and amphiphilic properties, making it suitable for use in surfactants, polymer additives, and drug delivery systems. Recent studies have explored its potential as a stabilizing agent in lipid nanoparticles, which are widely used in modern drug delivery technologies.

From a synthetic perspective, m-nitro-N-octadecylbenzamide can be synthesized through a series of well-established organic reactions, including nucleophilic substitution and amide formation. The starting material typically involves meta-nitrobenzoic acid, which undergoes activation to form an acid chloride or mixed anhydride before reacting with octadecylamine to yield the final product. This synthesis pathway has been optimized in recent research to improve yield and purity, ensuring scalability for industrial applications.

The physical and chemical properties of m-nitro-N-octadecylbenzamide are critical for its functionality in various applications. Its melting point is approximately 85–88°C, indicating moderate thermal stability, while its solubility profile shows better solubility in organic solvents like dichloromethane and DMF compared to water. These properties make it ideal for use in organic synthesis intermediates and as a component in complex molecular assemblies.

In terms of applications, m-nitro-N-octadecylbenzamide has found utility in several emerging fields. One notable area is its use as a stabilizer in lipid nanoparticles (LNPs), which are increasingly employed as delivery vehicles for nucleic acids such as mRNA vaccines. The amphiphilic nature of the compound allows it to form stable bilayers around the nucleic acid payload, protecting it from degradation while facilitating cellular uptake.

Recent research has also explored the potential of m-nitro-N-octadecylbenzamide as a precursor for bioconjugation reactions. Its amide group can serve as a reactive site for attaching biomolecules such as peptides or antibodies, enabling the creation of targeted drug delivery systems. Additionally, the nitro group provides opportunities for further functionalization through redox reactions or click chemistry.

The environmental impact of m-nitro-N-octadecylbenzamide is another area of interest, particularly given its potential use in large-scale industrial processes. Studies have shown that under aerobic conditions, the compound undergoes biodegradation at a moderate rate, suggesting that it may not persist long-term in natural environments. However, further research is needed to fully understand its environmental fate and toxicity profile.

In conclusion, m-nitro-N-octadecylbenzamide (CAS No. 109799-65-7) is a versatile compound with promising applications across multiple disciplines. Its unique structure combines aromatic stability with amphiphilic properties, making it a valuable tool in modern chemical synthesis and materials science. As research continues to uncover new uses and optimize its synthesis pathways, this compound is poised to play an increasingly important role in advancing technological and therapeutic innovations.

• 20857-92-5(1-(4-Nitrobenzoyl)piperidine)
• 3400-26-8(N-Methyl-3-nitrobenzamide)
• 2585-24-2(Benzamide,4-nitro-N-propyl-)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)