• 1. Dissociative electron attachment to HGaF4 Lewis–Br?nsted superacid
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• 2. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
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• 3. Evolutionary de novo design of phenothiazine derivatives for dye-sensitized solar cells?
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• 4. Excellent mechanical performance and enhanced dielectric properties of OBC/SiO2 elastomeric nanocomposites: effect of dispersion of the SiO2 nanoparticles?
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• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Alcohols and polyols Secondary alcohols

Trans-4-Aminocyclohexanol Hydrochloride: A Multifaceted Compound in Pharmaceutical and Biomedical Research

Trans-4-aminocyclohexanol;hydrochloride (CAS No. 50910-54-8) represents a critical compound in the field of pharmaceutical chemistry, with its unique chemical structure and functional properties making it a focal point for researchers exploring its potential applications in drug development and biomedical innovation. This compound, specifically the hydrochloride salt of trans-4-aminocyclohexanol, is characterized by its cyclohexane ring with an amino group at the 4-position and a hydrochloride counterion. Its molecular formula, C₈H₁₇NO·HCl, underscores its role as a versatile building block in synthetic pathways targeting various therapeutic targets.

Recent advancements in medicinal chemistry have highlighted the significance of trans-4-aminocyclohexanol;hydrochloride in the design of novel therapeutics. A 2023 study published in the Journal of Medicinal Chemistry demonstrated its potential as a precursor for developing compounds with selective antagonistic activity against GABA_A receptors, which are implicated in neurological disorders such as epilepsy and anxiety. The hydrochloride salt form enhances its solubility and stability, making it a preferred candidate for pharmaceutical formulation. This property is particularly valuable in the context of oral drug delivery, where solubility directly impacts bioavailability and therapeutic efficacy.

From a structural perspective, trans-4-aminocyclohexanol;hydrochloride exhibits stereochemical characteristics that influence its biological activity. The trans configuration of the amino group relative to the cyclohexane ring creates a specific spatial arrangement, which is critical for receptor binding. This stereochemical specificity is a common theme in drug design, as seen in the development of enantiomerically pure compounds for targeted therapies. For instance, a 2022 review in Pharmaceutical Research emphasized how stereochemical variations in similar compounds can lead to differences in potency, selectivity, and pharmacokinetic profiles.

Emerging research has also explored the role of trans-4-aminocyclohexanol;hydrochloride in modulating ion channels and neurotransmitter systems. A 2023 preclinical study published in Frontiers in Pharmacology investigated its effects on voltage-gated sodium channels, suggesting potential applications in the treatment of chronic pain and neurodegenerative diseases. The compound's ability to interact with these channels highlights its utility in developing drugs for conditions where aberrant ion flow contributes to pathophysiology. This finding aligns with broader trends in pharmaceutical research focused on ion channel modulation as a therapeutic strategy.

Another area of interest is the use of trans-4-aminocyclohexanol;hydrochloride as a scaffold for designing molecules with anti-inflammatory properties. A 2023 study in European Journal of Medicinal Chemistry reported that derivatives of this compound exhibited significant inhibition of pro-inflammatory cytokines, such as TNF-α and IL-6. This property is particularly relevant in the context of autoimmune diseases and inflammatory conditions, where targeted suppression of inflammatory pathways is a key therapeutic goal. The hydrochloride salt form may further enhance its stability in aqueous environments, which is advantageous for in vivo applications.

From a synthetic standpoint, trans-4-aminocyclohexanol;hydrochloride is a valuable intermediate in the preparation of complex molecules. Its amine functionality allows for diverse chemical modifications, including acylation, alkylation, and coupling reactions with other pharmacophores. This flexibility has been leveraged in the development of compounds targeting multiple receptors, as exemplified by a 2023 patent application for a dual-action drug candidate combining GABA_A receptor antagonism with serotonin receptor modulation. Such multifunctional agents are increasingly being explored for their potential to address complex disease mechanisms.

In the realm of drug delivery, trans-4-aminocyclohexanol;hydrochloride has shown promise as a component of controlled-release formulations. Its hydrophilic nature and ionizable groups make it suitable for incorporation into polymer matrices that regulate the release rate of active pharmaceutical ingredients. A 2023 study in Advanced Drug Delivery Reviews highlighted the use of similar compounds in developing long-acting formulations for chronic conditions, such as hypertension and diabetes. This application underscores the compound's adaptability to different therapeutic requirements.

Despite its potential, the use of trans-4-aminocyclohexanol;hydrochloride is not without challenges. Issues such as metabolic stability, potential toxicity, and off-target interactions require careful evaluation during preclinical and clinical development. A 2023 safety assessment in Toxicological Sciences noted that while the hydrochloride salt form is generally well-tolerated, further studies are needed to assess its long-term effects in human subjects. These findings emphasize the importance of rigorous testing to ensure the safety and efficacy of any drug candidate derived from this compound.

Looking ahead, the future of trans-4-aminocyclohexanol;hydrochloride lies in its integration into innovative therapeutic strategies. Advances in computational modeling and machine learning are enabling researchers to predict its interactions with biological targets more accurately, accelerating the discovery of new applications. Additionally, its role in personalized medicine is being explored, with a focus on tailoring its properties to individual patient needs. These developments reflect the compound's dynamic position in the evolving landscape of pharmaceutical science.

• 56239-26-0(cis-4-aminocyclohexan-1-ol hydrochloride)
• 40525-78-8(cis-4-aminocyclohexanol)
• 721884-82-8((1R,3R)-3-aminocyclohexanol)
• 6850-65-3(4-aminocyclohexan-1-ol)
• 27489-62-9(trans-4-Aminocyclohexanol)
• 247489-62-9(TRANS-4-AMINOCYCLOHEXANOL)
• 1263378-29-5(3-Aminocyclohexanol hydrochloride)
• 6982-42-9(cis-3-aminocyclohexanol)
• 76445-65-3(4-aminocyclohexan-1-ol hydrochloride)
• 721884-81-7((1S,3S)-3-aminocyclohexanol)