• 1. Establishing new scaling relations on two-dimensional MXenes for CO2 electroreduction?
  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
• 2. Dissolution of cork biopolymers in biocompatible ionic liquids
  Helga Garcia,Rui Ferreira,Marija Petkovic,Jamie L. Ferguson,Maria C. Leit?o,H. Q. Nimal Gunaratne,Luís Paulo N. Rebelo Green Chem., 2010,12, 367-369
• 3. Evidence of pre-micellar aggregates in aqueous solution of amphiphilic PDMS–PEO block copolymer?
  Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991
• 4. Fatty acid eutectic mixtures and derivatives from non-edible animal fat as phase change materials?
  Pau Gallart-Sirvent,Marc Martín,Gemma Villorbina,Mercè Balcells,Aran Solé,Luisa F. Cabeza,Ramon Canela-Garayoa RSC Adv., 2017,7, 24133-24139
• 5. Fate of single walled carbon nanotubes in wetland ecosystems?
  Joseph H. Bisesi,Tara Sabo-Attwood Environ. Sci.: Nano, 2014,1, 574-583

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzylamines 2-benzylaminopyridines

Introduction to 2-(Benzylamino)nicotinonitrile (CAS No. 50351-72-9)

2-(Benzylamino)nicotinonitrile, identified by the chemical compound code CAS No. 50351-72-9, is a specialized organic molecule that has garnered significant attention in the field of pharmaceutical chemistry and medicinal research. This compound, featuring a nitrile group and a benzylamino substituent, exhibits unique structural and functional properties that make it a valuable intermediate in the synthesis of various bioactive molecules. The benzylamino moiety, in particular, introduces a polar and relatively hydrophobic character, which can influence its solubility and interaction with biological targets. The nitrile group, on the other hand, serves as a versatile handle for further chemical modifications, enabling the construction of more complex structures through reactions such as hydrolysis or reduction.

The synthesis of 2-(Benzylamino)nicotinonitrile typically involves multi-step organic transformations, starting from readily available precursors. One common synthetic route involves the nucleophilic substitution of a halogenated nicotinonitrile derivative with benzylamine, where the choice of solvent and reaction conditions plays a crucial role in optimizing yield and purity. Advanced techniques such as palladium-catalyzed cross-coupling reactions have also been explored to enhance the efficiency of the synthesis, particularly in cases where traditional methods may suffer from poor regioselectivity or low yields.

In recent years, 2-(Benzylamino)nicotinonitrile has been studied for its potential applications in drug discovery and development. Its structural framework suggests compatibility with various biological pathways, making it a promising scaffold for designing novel therapeutic agents. For instance, derivatives of this compound have been investigated for their antimicrobial properties, with some studies indicating activity against Gram-negative bacteria through mechanisms involving disruption of bacterial cell wall synthesis. Additionally, the benzylamino group provides a site for attachment to pharmacophores that can enhance binding affinity to specific protein targets.

One particularly intriguing aspect of 2-(Benzylamino)nicotinonitrile is its role in the development of kinase inhibitors. Kinases are enzymes that play critical roles in cell signaling pathways and are often implicated in diseases such as cancer and inflammatory disorders. By modifying the core structure of 2-(Benzylamino)nicotinonitrile, researchers have synthesized compounds that exhibit potent inhibitory effects on specific kinases. These inhibitors have shown promise in preclinical studies, demonstrating selectivity over closely related enzymes and minimal off-target effects. The nitrile group in these derivatives can be further functionalized to improve solubility and pharmacokinetic properties, making them more suitable for clinical development.

The pharmaceutical industry has also explored 2-(Benzylamino)nicotinonitrile as a building block for antiviral agents. Viruses rely on host cellular machinery for replication, and targeting viral enzymes or proteins can disrupt their life cycle. Researchers have designed analogs of 2-(Benzylamino)nicotinonitrile that inhibit viral proteases or polymerases, effectively blocking viral replication. Some of these compounds have demonstrated efficacy against RNA viruses, including those responsible for certain types of hepatitis and influenza. The ability to fine-tune the structure of these derivatives allows for the optimization of antiviral activity while minimizing toxicity.

Beyond its pharmaceutical applications, 2-(Benzylamino)nicotinonitrile has found utility in materials science and agrochemical research. Its unique electronic properties make it a candidate for use in organic semiconductors and light-emitting diodes (OLEDs). In agrochemicals, derivatives of this compound have been investigated for their potential as herbicides or fungicides, offering new solutions to crop protection challenges. The versatility of 2-(Benzylamino)nicotinonitrile lies in its ability to undergo diverse chemical transformations, allowing chemists to tailor its properties for specific applications.

The latest research trends indicate that 2-(Benzylamino)nicotinonitrile is being increasingly used in combination therapies to enhance therapeutic outcomes. By pairing this compound with other bioactive molecules, researchers aim to achieve synergistic effects that improve treatment efficacy while reducing side effects. For example, studies have shown that combining kinase inhibitors derived from 2-(Benzylamino)nicotinonitrile with chemotherapy agents can lead to more effective cancer treatments. This approach leverages the complementary mechanisms of action of different drugs to overcome drug resistance and improve patient outcomes.

Advances in computational chemistry have also played a significant role in the study of 2-(Benzylamino)nicotinonitrile. Molecular modeling techniques allow researchers to predict the behavior of this compound in various environments, including its interactions with biological targets. These simulations help guide experimental design by identifying potential binding sites and optimizing drug-like properties such as solubility and metabolic stability. The integration of experimental data with computational predictions has accelerated the discovery process significantly.

In conclusion,2-(Benzylamino)nicotinonitrile (CAS No. 50351-72-9) is a versatile compound with broad applications across multiple scientific disciplines. Its unique structural features make it an invaluable tool for synthesizing novel bioactive molecules with potential therapeutic benefits. As research continues to uncover new applications and refine synthetic methodologies,2-(Benzylamino)nicotinonitrile is poised to remain at the forefront of chemical innovation.

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