• 1. An insight into the hybridization mechanism of hairpin DNA physically immobilized on chemically modified graphenes
  Adeline Huiling Loo,Alessandra Bonanni,Martin Pumera Analyst, 2013,138, 467-471
• 2. An asymmetric supercapacitor based on controllable WO3 nanorod bundle and alfalfa-derived porous carbon?
  Kanjun Sun,Fengting Hua,Shuzhen Cui,Yanrong Zhu,Hui Peng,Guofu Ma RSC Adv., 2021,11, 37631-37642
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Nitrobenzenes

Comprehensive Guide to 5-Bromo-1-Fluoro-2-Methyl-3-Nitro-Benzene (CAS No. 502496-34-6)

5-Bromo-1-fluoro-2-methyl-3-nitro-benzene (CAS 502496-34-6) is a specialized aromatic compound widely used in pharmaceutical and agrochemical research. Its unique structural features, including the presence of bromine, fluorine, and nitro functional groups, make it a valuable intermediate in organic synthesis. Researchers and industry professionals frequently search for 5-bromo-1-fluoro-2-methyl-3-nitro-benzene suppliers, synthesis methods, and applications in drug discovery, reflecting its growing importance in modern chemistry.

The compound's molecular formula is C₇H₅BrFNO₂, with a molecular weight of 234.02 g/mol. Its distinctive multifunctional benzene derivative structure enables diverse chemical transformations, particularly in the development of fluorinated pharmaceuticals—a trending topic due to the increasing demand for fluorine-containing drugs in 2024. The presence of both electron-withdrawing (nitro, fluorine) and electron-donating (methyl) groups creates interesting reactivity patterns that organic chemists exploit for selective substitutions.

Current market trends show heightened interest in halogenated benzene derivatives, with 502496-34-6 gaining attention for its role in creating: PET imaging agents (addressing the global push for advanced diagnostic tools), crop protection chemicals (responding to sustainable agriculture demands), and electronic materials (for next-gen OLED development). These applications align perfectly with Google's "People Also Ask" queries like "How are fluorinated compounds used in medicine?" and "What are nitroaromatics used for?"

From a synthetic chemistry perspective, 5-bromo-1-fluoro-2-methyl-3-nitro-benzene serves as a crucial building block for: Suzuki coupling reactions (highly searched in 2024 for C-C bond formation), nucleophilic aromatic substitutions (facilitated by the fluorine atom), and reductive amination processes. The bromine atom at position 5 makes it particularly valuable for cross-coupling chemistry—a hot topic in pharmaceutical research forums.

Quality specifications for CAS 502496-34-6 typically require ≥98% purity (HPLC), with special attention to residual solvent levels. Analytical techniques like GC-MS, HPLC, and NMR (1H, 13C, 19F) are essential for characterization—keywords frequently appearing in research papers and patent applications. The compound's stability under inert atmosphere makes it suitable for long-term storage, though recommendations suggest protection from light due to the nitro group's photosensitivity.

Environmental and handling considerations for 5-bromo-1-fluoro-2-methyl-nitrobenzene follow standard laboratory protocols for aromatic compounds. While not classified as hazardous under most regulations, proper ventilation is advised during handling—a point emphasized in recent green chemistry discussions. The compound's environmental fate and biodegradation pathways are subjects of ongoing research, particularly regarding fluorinated organic pollutants (a trending environmental concern).

The global market for multifunctional benzene derivatives like 502496-34-6 is projected to grow at 6.2% CAGR (2024-2030), driven by pharmaceutical R&D in North America and Asia-Pacific regions. Patent analysis reveals increasing use in: kinase inhibitor development (cancer therapeutics), herbicide intermediates (addressing food security challenges), and liquid crystal materials (for flexible displays). These applications respond directly to search trends like "new cancer drug intermediates 2024" and "agricultural chemical innovations."

For researchers working with 5-bromo-1-fluoro-2-methyl-3-nitro-benzene, recent literature highlights innovative applications in: metal-organic frameworks (MOFs) for gas storage, fluorescent probes for cellular imaging, and catalysis—all areas experiencing high Google search volumes. The compound's structural versatility continues to inspire novel synthetic routes, with particular interest in flow chemistry and photocatalysis approaches that dominate current chemistry conference topics.

In summary, 5-bromo-1-fluoro-2-methyl-3-nitro-benzene (CAS 502496-34-6) represents a strategically important compound at the intersection of multiple research frontiers. Its value as a pharmaceutical intermediate, combined with emerging applications in materials science and agrochemistry, ensures its continued relevance in scientific and industrial contexts. The compound perfectly illustrates how multifunctional aromatic building blocks address contemporary challenges in drug development, sustainable agriculture, and advanced materials—making it a frequent subject in both academic publications and commercial inquiries.

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