• 1. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
• 2. Excimer and exciplex formation in a pair of bright phosphorescent isomers constructed from Cu3(pyrazolate)3 and Cu3I3 coordination luminophores?
  Shun-Ze Zhan,Mian Li,Xiao-Ping Zhou,Dan Li,Seik Weng Ng RSC Adv., 2011,1, 1457-1459
• 3. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
• 4. Dissociation of aryl sulfonyl phthalimide radical anions: relevance to the biological activity of arylsulfonyl amides?
  Abdelaziz Houmam,Emad M. Hamed Chem. Commun., 2012,48, 11328-11330
• 5. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenylhydrazines
• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides

Comprehensive Overview of 2,6-Difluorophenylhydrazine Hydrochloride (CAS No. 502496-26-6)

2,6-Difluorophenylhydrazine hydrochloride (CAS No. 502496-26-6) is a specialized organic compound widely utilized in pharmaceutical and agrochemical research. Its unique structural properties, featuring two fluorine atoms at the ortho positions of the phenyl ring, make it a valuable intermediate in synthesizing heterocyclic compounds. Researchers often search for 2,6-difluorophenylhydrazine HCl applications or synthesis methods for fluorinated hydrazines, reflecting its growing relevance in drug discovery and material science.

The compound’s significance stems from its role in constructing fluorinated scaffolds, a trending topic in medicinal chemistry due to the enhanced bioavailability and metabolic stability imparted by fluorine atoms. Recent studies highlight its use in developing kinase inhibitors and antiviral agents, aligning with global interest in targeted therapies and infectious disease control. Searches like "2,6-difluorophenylhydrazine hydrochloride solubility" or "stability under acidic conditions" indicate user focus on practical handling parameters.

From a synthetic perspective, 502496-26-6 serves as a precursor for pyrazole and indazole derivatives, classes of compounds frequently investigated for their bioactivity. Its electrophilic reactivity enables efficient coupling reactions, a feature exploited in combinatorial chemistry. Queries such as "alternative routes to 2,6-difluorophenylhydrazine" or "green chemistry approaches" mirror the demand for sustainable synthetic protocols.

Analytical characterization of 2,6-Difluorophenylhydrazine HCl typically involves HPLC purity analysis, NMR spectroscopy, and mass spectrometry. These techniques address common user concerns about batch-to-batch consistency and impurity profiling, critical for reproducibility in research. The compound’s hygroscopic nature also prompts searches for storage recommendations, emphasizing the need for anhydrous conditions.

In material science, this fluorinated hydrazine derivative contributes to the design of liquid crystal materials and organic semiconductors, areas gaining traction in flexible electronics. Discussions around structure-property relationships of fluorinated aromatics often reference CAS 502496-26-6 as a model system, underscoring its interdisciplinary importance.

Regulatory-wise, proper documentation of safety data sheets (SDS) for 2,6-difluorophenylhydrazine hydrochloride remains essential, though it falls outside restricted categories. Frequent searches for handling precautions and waste disposal methods reflect responsible usage practices within laboratories.

Emerging applications include its incorporation into fluorescent probes for bioimaging, leveraging the fluorine atoms’ effects on photophysical properties. This aligns with the surge in demand for diagnostic tools, as seen in searches for "fluorophore synthesis using phenylhydrazines."

The commercial availability of CAS 502496-26-6 through specialty chemical suppliers caters to the needs of contract research organizations (CROs) and academic institutions. Price trends and bulk purchase options are frequently queried, indicating its established market presence.

Future research directions may explore its utility in click chemistry or metal-organic frameworks (MOFs), given the compound’s bifunctional reactivity. Such potential keeps 2,6-Difluorophenylhydrazine Hydrochloride at the forefront of innovative chemical methodologies.

• 2368-80-1(2-Fluorophenylhydrazine)
• 51523-79-6(2,4-Difluorophenylhydrazine hydrochloride)
• 8002-53-7(2,4,6-Trifluorophenylhydrazine)
• 828-73-9(Pentafluorophenylhydrazine)
• 97108-50-4(2,5-Difluorophenylhydrazine)
• 80025-72-5(2,4,6-Trifluorophenylhydrazine)
• 40594-30-7((2,4-difluorophenyl)hydrazine Hydrochloride)
• 2924-15-4((2-fluorophenyl)hydrazine hydrochloride)
• 175135-73-6(2,5-Difluorophenylhydrazine hydrochloride)
• 653-11-2(2,3,5,6-tetrafluorophenylhydrazine)