• 1. Color tuning associated with heteroleptic cyclometalated Ir(iii) complexes: influence of the ancillary ligand
  Chau-Jiun Chang,Cheng-Han Yang,Kellen Chen,Yun Chi,Ching-Fong Shu,Mei-Lin Ho,Yu-Shan Yeh,Pi-Tai Chou Dalton Trans. 2007 1881
• 2. The pentafluorosulfanyl group in cannabinoid receptor ligands: synthesis and comparison with trifluoromethyl and tert-butyl analogues
  Stefano Altomonte,Gemma L. Baillie,Ruth A. Ross,Jennifer Riley,Matteo Zanda RSC Adv. 2014 4 20164
• 3. Synthesis of 1H-4,1,2-benzothiadiazines from substituted N-acetyl-N-aryl-N′-thioaroylhydrazines
  Patrick D. Callaghan,Martin S. Gibson,Arthur J. Elliott J. Chem. Soc. Perkin Trans. 1 1975 1386
• 4. Alginate–copper microspheres as efficient and reusable heterogeneous catalysts for the one-pot synthesis of 4-organylselanyl-1H-pyrazoles
  Jaqueline F. Souza,Thalita F. B. de Aquino,José E. R. Nascimento,Raquel G. Jacob,André R. Fajardo Catal. Sci. Technol. 2020 10 3918
• 5. Predicting the photoinduced electron transfer thermodynamics in polyfluorinated 1,3,5-triarylpyrazolines based on multiple linear free energy relationships
  Manjusha Verma,Aneese F. Chaudhry,Christoph J. Fahrni Org. Biomol. Chem. 2009 7 1536

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenylhydrazines

Introduction to (2,4-difluorophenyl)hydrazine Hydrochloride (CAS No. 40594-30-7)

The compound (2,4-difluorophenyl)hydrazine hydrochloride (CAS No. 40594-30-7) is a significant chemical entity in the field of organic chemistry and pharmaceutical research. This compound, also referred to as difluorophenylhydrazine hydrochloride, has garnered attention due to its unique structural properties and potential applications in drug development and material science.

Chemical Structure and Properties

(2,4-difluorophenyl)hydrazine hydrochloride consists of a phenyl ring substituted with two fluorine atoms at the 2 and 4 positions, connected to a hydrazine group (-NHNH2), which is further protonated by a hydrochloric acid molecule. This structure imparts the compound with distinct chemical properties, including high reactivity and the ability to form stable complexes with various metal ions. Recent studies have highlighted its role as an intermediate in the synthesis of advanced organic molecules, particularly in the development of novel pharmaceutical agents.

Synthesis and Applications

The synthesis of (2,4-difluorophenyl)hydrazine hydrochloride involves a multi-step process that typically begins with the fluorination of an aromatic ring followed by hydrazination. Recent advancements in catalytic methods have improved the efficiency and selectivity of this synthesis pathway. The compound is widely used as an intermediate in the production of heterocyclic compounds, which are crucial components in many drugs and agrochemicals.

One of the most promising applications of (2,4-difluorophenyl)hydrazine hydrochloride is in the field of medicinal chemistry. Researchers have utilized this compound to develop bioactive molecules targeting various disease states, including cancer and neurodegenerative disorders. For instance, a study published in *Journal of Medicinal Chemistry* demonstrated its potential as a lead compound for designing inhibitors of key enzymes involved in tumor progression.

Toxicological Studies

Understanding the safety profile of (2,4-difluorophenyl)hydrazine hydrochloride is essential for its application in therapeutic development. Recent toxicological studies have evaluated its acute and chronic toxicity profiles in experimental models. These studies suggest that while the compound exhibits moderate toxicity at high doses, it demonstrates acceptable safety margins under controlled conditions.

Future Directions

The continued exploration of (2,4-difluorophenyl)hydrazine hydrochloride is expected to uncover new avenues for its utilization. Ongoing research focuses on optimizing its synthesis for large-scale production and investigating its role in green chemistry applications. Additionally, collaborative efforts between academic institutions and pharmaceutical companies are paving the way for innovative uses of this compound in drug delivery systems and nanotechnology.

• 2368-80-1(2-Fluorophenylhydrazine)
• 51523-79-6(2,4-Difluorophenylhydrazine hydrochloride)
• 828-73-9(Pentafluorophenylhydrazine)
• 8002-53-7(2,4,6-Trifluorophenylhydrazine)
• 97108-50-4(2,5-Difluorophenylhydrazine)
• 80025-72-5(2,4,6-Trifluorophenylhydrazine)
• 119452-66-3(2,6-Difluorophenylhydrazine)
• 2924-15-4((2-fluorophenyl)hydrazine hydrochloride)
• 175135-73-6(2,5-Difluorophenylhydrazine hydrochloride)
• 653-11-2(2,3,5,6-tetrafluorophenylhydrazine)