• 1. An artificial CO-releasing metalloprotein built by histidine-selective metallation?
  Inês S. Albuquerque,Hélia F. Jeremias,Miguel Chaves-Ferreira,Dijana Matak-Vinkovic,Omar Boutureira,Carlos C. Rom?o Chem. Commun., 2015,51, 3993-3996
• 2. Alternative donor substrates for inverting and retaining glycosyltransferases?
  Luke L. Lairson,Warren W. Wakarchuk Chem. Commun., 2007, 365-367
• 3. An antioxidant self-healing hydrogel for 3D cell cultures?
  Lei Yang,Yuan Zeng,Haibo Wu,Chunwu Zhou,Lei Tao J. Mater. Chem. B, 2020,8, 1383-1388
• 4. An integrated system for field analysis of Cd(ii) and Pb(ii) via preconcentration using nano-TiO2/cellulose paper composite and subsequent detection with a portable X-ray fluorescence spectrometer?
  Xiaofeng Lin RSC Adv., 2016,6, 9002-9006
• 5. Aggregated-fluorescent detection of PFAS with a simple chip
  Cheng Fang,Jinjian Wu,Zahra Sobhani,Md. Al Amin,Youhong Tang Anal. Methods, 2019,11, 163-170

Indophenol (CAS No. 500-85-6): An Overview of Its Properties, Applications, and Recent Research

Indophenol (CAS No. 500-85-6) is a versatile compound with a wide range of applications in the fields of chemistry, biology, and medicine. This aromatic compound, also known as 3-indolylphenol or indole-3-phenol, is characterized by its unique molecular structure, which consists of an indole ring and a phenolic group. The combination of these functional groups endows Indophenol with a variety of chemical and biological properties that make it a valuable compound in both academic research and industrial applications.

The molecular formula of Indophenol is C₁₂H₁₁NO₂, and its molecular weight is approximately 197.22 g/mol. The compound is typically a white to light yellow crystalline solid at room temperature, with a melting point ranging from 187 to 190°C. It is sparingly soluble in water but exhibits good solubility in organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO). These physical properties make Indophenol suitable for various analytical and preparative techniques.

In the realm of chemical synthesis, Indophenol serves as an important intermediate in the production of dyes, pigments, and pharmaceuticals. Its phenolic group can undergo various reactions, including esterification, etherification, and oxidation, making it a valuable building block for the synthesis of more complex molecules. Additionally, the indole ring provides a platform for the introduction of functional groups that can modulate the biological activity of the final product.

In biological research, Indophenol has gained attention for its potential therapeutic applications. Recent studies have explored its antioxidant properties, which are attributed to its ability to scavenge free radicals and inhibit lipid peroxidation. This makes Indophenol a promising candidate for the development of antioxidants that can be used to combat oxidative stress-related diseases such as cardiovascular disease, neurodegenerative disorders, and cancer.

A study published in the Journal of Medicinal Chemistry in 2022 investigated the antioxidant activity of Indophenol derivatives. The researchers found that certain derivatives exhibited potent antioxidant activity in vitro, as measured by their ability to inhibit lipid peroxidation in cell cultures. These findings suggest that Indophenol-based compounds could be developed into novel therapeutic agents for the treatment of oxidative stress-related conditions.

Beyond its antioxidant properties, Indophenol has also been studied for its potential anti-inflammatory effects. Inflammation is a key factor in many chronic diseases, and compounds that can effectively reduce inflammation have significant therapeutic value. A study published in the Journal of Inflammation Research in 2021 evaluated the anti-inflammatory activity of Indophenol in an animal model of inflammatory bowel disease (IBD). The results showed that treatment with Indophenol significantly reduced inflammation markers and improved intestinal health in the treated animals.

The potential anticancer properties of Indophenol have also been explored in recent research. A study published in Cancer Letters in 2023 investigated the effects of Indophenol on human colorectal cancer cells. The researchers found that treatment with Indophenol led to significant inhibition of cell proliferation and induction of apoptosis (programmed cell death). These findings suggest that Indophenol-based compounds could be developed into novel anticancer agents for the treatment of colorectal cancer.

In addition to its therapeutic applications, Indophenol strong > has been used as a reagent in various analytical techniques. Its strong absorbance at specific wavelengths makes it useful as a chromogenic agent in colorimetric assays. For example, it has been used to detect trace amounts of hydrogen peroxide in biological samples, which is important for monitoring oxidative stress levels in cells and tissues.

The environmental impact of chemical compounds is an increasingly important consideration in their development and use. Recent studies have investigated the biodegradability and ecotoxicity of < strong > Indophenol strong > . A study published in Environmental Science & Technology in 2022 found that under aerobic conditions, Indophenol was readily biodegraded by microorganisms present in soil and water environments. This suggests that Indophenol has a relatively low environmental impact when released into natural systems.

In conclusion, Indophenol (CAS No. 500-85-6) is a multifaceted compound with a wide range of applications in chemistry, biology, and medicine. Its unique molecular structure endows it with valuable chemical properties and biological activities that make it a promising candidate for various therapeutic applications. Ongoing research continues to uncover new potential uses for Indophenol , further highlighting its importance as a versatile compound in both academic research and industrial settings.

• 7512-50-7(2,5-Cyclohexadien-1-one,4-(1-naphthalenylimino)-)
• 2582-33-4(2,5-Cyclohexadien-1-one,2,6-dibromo-4-[(4-hydroxyphenyl)imino]-)
• 67979-39-9(2,5-Cyclohexadien-1-one, 4-[(4-methoxyphenyl)imino]-)
• 2582-31-2(2,5-Cyclohexadien-1-one, 4-[(4-hydroxy-2-methylphenyl)imino]-)
• 24093-23-0(Phenol,4-[(2-amino-4-imino-2,5-cyclohexadien-1-ylidene)amino]-)
• 2406-04-4(2,5-Cyclohexadien-1-one, 4-(phenylimino)-)
• 2582-41-4(2,5-Cyclohexadien-1-one,4-[(2-chloro-4-hydroxyphenyl)imino]-)
• 5418-36-0(2,5-Cyclohexadien-1-one,4-[(4-hydroxy-2-methylphenyl)imino]-, sodium salt (1:1))
• 5418-32-6(2,5-Cyclohexadien-1-one,4-[(4-hydroxyphenyl)imino]-, sodium salt (1:1))
• 6201-72-5(2,5-Cyclohexadien-1-one,4-[(4-amino-8-hydroxy-1-naphthalenyl)imino]-)