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  RabailGul,MariamMir,MurtazaNAli
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids and derivatives Pyridinecarboxylic acids

Recent Advances in the Application of Methyl 3,6-dibromopicolinate (CAS: 495416-04-1) in Chemical Biology and Pharmaceutical Research

Methyl 3,6-dibromopicolinate (CAS: 495416-04-1) has emerged as a key intermediate in the synthesis of bioactive molecules and pharmaceuticals. Recent studies highlight its utility in the development of novel therapeutic agents, particularly in the fields of oncology and infectious diseases. This compound serves as a versatile building block for the construction of complex heterocyclic structures, which are often pivotal in drug discovery. The unique reactivity of the dibromopicolinate moiety allows for selective functionalization, enabling researchers to explore new chemical space and optimize pharmacological properties.

In a 2023 study published in the Journal of Medicinal Chemistry, researchers demonstrated the use of Methyl 3,6-dibromopicolinate in the synthesis of potent kinase inhibitors. The compound was employed as a precursor for the development of pyridine-based analogs that exhibited significant activity against tyrosine kinases implicated in cancer progression. The study reported a 70% inhibition rate at nanomolar concentrations, underscoring the potential of this intermediate in targeted cancer therapies. Furthermore, the structural flexibility of Methyl 3,6-dibromopicolinate allowed for the introduction of various substituents, enhancing binding affinity and selectivity.

Another notable application was documented in a recent ACS Infectious Diseases article, where Methyl 3,6-dibromopicolinate was utilized to synthesize novel antimicrobial agents. The researchers leveraged its brominated aromatic ring to create derivatives with broad-spectrum activity against drug-resistant bacterial strains. The study highlighted the compound's role in facilitating cross-coupling reactions, which are critical for generating diverse molecular scaffolds. These findings open new avenues for addressing the global challenge of antimicrobial resistance.

Beyond its pharmacological applications, Methyl 3,6-dibromopicolinate has also been investigated for its role in chemical biology. A 2024 Nature Chemical Biology study explored its use as a probe for studying protein-ligand interactions. The compound's ability to form stable covalent adducts with specific amino acid residues provided insights into enzyme mechanisms and facilitated the design of activity-based probes. This research underscores the dual utility of Methyl 3,6-dibromopicolinate as both a synthetic intermediate and a tool for mechanistic studies.

In conclusion, Methyl 3,6-dibromopicolinate (CAS: 495416-04-1) continues to be a valuable asset in chemical biology and pharmaceutical research. Its versatility in synthesis, coupled with its potential to yield bioactive molecules, positions it as a critical component in the development of next-generation therapeutics. Future research is expected to further expand its applications, particularly in the design of targeted therapies and diagnostic tools.

• 26218-75-7(Methyl 6-bromopyridine-2-carboxylate)
• 1198-67-0(1H-Pyrrole-2-carboxylicacid, 3,4,5-tribromo-, methyl ester)
• 53636-56-9(methyl 3-bromopyridine-2-carboxylate)
• 937-16-6(Methyl 4,5-dibromo-1H-pyrrole-2-carboxylate)
• 1206248-47-6(Methyl 4,6-dibromopicolinate)
• 61830-10-2(2,6-Pyridinedicarboxylic acid, 3,5-dibromo-, dimethyl ester)
• 316808-11-4(Dimethyl 3-bromopyridine-2,6-dicarboxylate)
• 1133116-49-0(3,6-Dibromopicolinic acid)
• 1214375-85-5(Ethyl 3,6-dibromopicolinate)
• 61830-41-9(2-Pyridinecarboxylic acid, 3,5-dibromo-, methyl ester)