Production Method 1

104-87-0

3153-32-0

495406-14-9

87661-20-9

Reaction Conditions

1.1 Reagents: Potassium tert-butoxide Solvents: Tetrahydrofuran ;  20 min, -30 °C
1.2 Reagents: Ammonium chloride Solvents: Water
1.3 Solvents: Water

Reference

New reactions of γ-halo carbanions: simple synthesis of substituted tetrahydrofurans

Makosza, Mieczyslaw; et al, Chemistry - A European Journal, 2002, 8(18), 4234-4240

3-Furancarboxylic acid, tetrahydro-2-(4-methylphenyl)-, 1,1-dimethylethyl ester, (2R,3R)-rel- Raw materials

• 4-Methylbenzaldehyde
• tert-butyl 4-chlorobutanoate

3-Furancarboxylic acid, tetrahydro-2-(4-methylphenyl)-, 1,1-dimethylethyl ester, (2R,3R)-rel- Preparation Products

• 3-Furancarboxylic acid, tetrahydro-2-(4-methylphenyl)-, 1,1-dimethylethyl ester, (2R,3R)-rel- (495406-14-9)
• Tert-butyl cyclopropanecarboxylate (87661-20-9)

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