• 1. Excellent peroxidase mimicking property of CuO/Pt nanocomposites and their application as an ascorbic acid sensor?
  Xinhuan Wang,Shuangfei Cai,Cui Qi Analyst, 2017,142, 2500-2506
• 2. Fe(ii)-Assisted one-pot synthesis of ultra-small core–shell Au–Pt nanoparticles as superior catalysts towards the HER and ORR?
  Yi Cao,Yujiao Xiahou,Lixiang Xing,Xiang Zhang,Hong Li,ChenShou Wu,Haibing Xia Nanoscale, 2020,12, 20456-20466
• 3. Exchangeability of amino acid residues with similar physicochemical properties in coiled-coil interactions?
  Guiying Zhang,Maosheng Cheng,Yanni Li,Keliang Liu,Lifeng Cai Chem. Commun., 2013,49, 11086-11088
• 4. Emerging enantiomeric resolution materials with homochiral nano-fabrications
  Ji-Ping Wei Nanoscale, 2015,7, 11815-11832
• 5. Evolutionary de novo design of phenothiazine derivatives for dye-sensitized solar cells?
  Vishwesh Venkatraman,Marco Foscato,Vidar R. Jensen,Bj?rn K?re Alsberg J. Mater. Chem. A, 2015,3, 9851-9860

(4-Fluoro-2-propoxyphenyl)boronic acid (CAS No. 480438-60-6): A Comprehensive Overview

(4-Fluoro-2-propoxyphenyl)boronic acid (CAS No. 480438-60-6) is a versatile and important compound in the field of organic synthesis and medicinal chemistry. This boronic acid derivative has gained significant attention due to its unique properties and wide-ranging applications, particularly in the development of pharmaceuticals and materials science.

The chemical structure of (4-Fluoro-2-propoxyphenyl)boronic acid consists of a phenyl ring substituted with a fluoro group at the 4-position and a propoxy group at the 2-position, with a boronic acid functional group attached to the phenyl ring. This combination of substituents imparts specific reactivity and stability characteristics that make it a valuable building block in various synthetic processes.

In recent years, (4-Fluoro-2-propoxyphenyl)boronic acid has been extensively studied for its potential in Suzuki-Miyaura coupling reactions, which are widely used in the synthesis of biologically active compounds, including pharmaceuticals and agrochemicals. The boronic acid functional group facilitates these coupling reactions by forming stable intermediates that can be readily converted into desired products under mild conditions.

One of the key advantages of (4-Fluoro-2-propoxyphenyl)boronic acid is its ability to participate in selective and efficient cross-coupling reactions. This is particularly important in the synthesis of complex molecules where precise control over functional group placement is crucial. For instance, a study published in the Journal of Organic Chemistry demonstrated the successful use of this compound in the synthesis of a series of fluoro-substituted aryl ethers, which exhibited potent anti-inflammatory properties.

Moreover, (4-Fluoro-2-propoxyphenyl)boronic acid has shown promise in the development of novel materials, such as polymers and catalysts. Its unique electronic properties make it an attractive candidate for applications in electronic devices and sensors. A recent study in Advanced Materials highlighted the use of this compound as a monomer in the synthesis of conjugated polymers with enhanced optical and electronic properties.

The synthesis of (4-Fluoro-2-propoxyphenyl)boronic acid typically involves several steps, including the formation of the fluoro-substituted phenol intermediate and subsequent conversion to the boronic acid derivative. Various synthetic routes have been reported, each with its own advantages and limitations. For example, one common method involves the reaction of 4-fluoro-2-hydroxyacetophenone with propylene oxide followed by hydroboration and oxidation to form the desired product.

The purity and stability of (4-Fluoro-2-propoxyphenyl)boronic acid are critical factors that influence its performance in various applications. High-purity samples are essential for achieving consistent results in synthetic reactions and ensuring the reliability of downstream processes. Techniques such as column chromatography and recrystallization are commonly employed to purify this compound to high levels.

In terms of safety, while (4-Fluoro-2-propoxyphenyl)boronic acid is generally considered safe for laboratory use when proper handling protocols are followed, it is important to note that boronic acids can be sensitive to air and moisture. Therefore, storage conditions should be carefully controlled to maintain the integrity and reactivity of the compound.

The future prospects for (4-Fluoro-2-propoxyphenyl)boronic acid are promising, driven by ongoing research into new synthetic methods and applications. As scientists continue to explore its potential, it is likely that this compound will play an increasingly important role in various fields, from drug discovery to materials science.

In conclusion, (4-Fluoro-2-propoxyphenyl)boronic acid (CAS No. 480438-60-6) is a valuable compound with a wide range of applications in organic synthesis, medicinal chemistry, and materials science. Its unique chemical structure and reactivity make it an essential building block for developing new molecules with diverse functionalities. As research progresses, it is expected that this compound will continue to contribute significantly to scientific advancements and technological innovations.

• 179899-07-1((4-fluoro-2-methoxyphenyl)boronic acid)
• 192376-68-4((3-Fluoro-4-propoxyphenyl)boronic acid)
• 480438-58-2((2-ethoxy-4-fluorophenyl)boronic acid)
• 850589-54-7(3-Fluoro-5-isopropoxyphenylboronic acid)
• 850589-53-6(3-Ethoxy-5-fluorophenylboronic acid)
• 870777-18-7(2-Fluoro-6-propoxyphenylboronic acid)
• 957062-68-9(2-Ethoxy-6-fluorophenylboronic acid)
• 150145-25-8(2,4-Dipropoxyphenylboronic acid)
• 870777-19-8(2-Butoxy-6-fluorophenylboronic acid)
• 870778-87-3(4,5-Difluoro-2-ethoxyphenylboronic acid)