• 1. An autonomous self-optimizing flow machine for the synthesis of pyridine–oxazoline (PyOX) ligands?
  Eric Wimmer,Daniel Cortés-Borda,Solène Brochard,Elvina Barré,Charlotte Truchet,Fran?ois-Xavier Felpin React. Chem. Eng., 2019,4, 1608-1615
• 2. An approach to 7-aza-1-phosphanorbornane complexes: strain promoted rearrangement of 1-iminylphosphirane complexes and cycloaddition with olefins?
  Yang Xu,Min Wang,Donghui Wei,Rongqiang Tian,Zheng Duan,Fran?ois Mathey Dalton Trans., 2019,48, 5523-5526
• 3. An insight into the hybridization mechanism of hairpin DNA physically immobilized on chemically modified graphenes
  Adeline Huiling Loo,Alessandra Bonanni,Martin Pumera Analyst, 2013,138, 467-471
• 4. An integrated process of CO2 capture and in situ hydrogenation to formate using a tunable ethoxyl-functionalized amidine and Rh/bisphosphine system?
  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002
• 5. An Appraisal of pH triggered Bacitracin drug release, through composite hydrogel systems
  RabailGul,MariamMir,MurtazaNAli

• Solvents and Organic Chemicals Organic Compounds Nucleosides, nucleotides, and analogues Pyrimidine nucleosides Pyrimidine nucleosides
• Solvents and Organic Chemicals Organic Compounds Nucleosides, nucleotides, and analogues Pyrimidine nucleosides

Recent Advances in the Study of 5-Methyluridine-3'-13C and Its Applications in Chemical Biology and Medicine

The compound 5-Methyluridine-3'-13C, a stable isotope-labeled nucleoside derivative, has garnered significant attention in recent years due to its pivotal role in metabolic tracing, drug development, and nucleic acid research. With the CAS number 478511-00-1, this labeled nucleoside serves as a critical tool for investigating RNA modifications, metabolic pathways, and the pharmacokinetics of nucleoside-based therapeutics. Recent studies have highlighted its utility in NMR-based structural biology and mass spectrometry-based metabolomics, providing unprecedented insights into cellular processes.

One of the key applications of 5-Methyluridine-3'-13C is in the study of RNA modifications, particularly in the context of epitranscriptomics. Researchers have utilized this labeled compound to track the incorporation of methyl groups into RNA strands, shedding light on the dynamic nature of RNA methylation and its regulatory roles in gene expression. A 2023 study published in *Nucleic Acids Research* demonstrated that 5-Methyluridine-3'-13C can be effectively used to quantify methylation rates in tRNA and mRNA, offering a robust method for understanding post-transcriptional modifications.

In drug development, 5-Methyluridine-3'-13C has been employed to study the metabolic stability and bioavailability of nucleoside analogs. For instance, a recent preclinical investigation highlighted its use in tracing the metabolic fate of antiviral and anticancer nucleoside drugs. By incorporating the 13C label, researchers were able to monitor drug metabolism in real-time using advanced imaging techniques such as PET and MRI, thereby optimizing drug formulations and dosing regimens.

Furthermore, the compound has found applications in structural biology, where it aids in the elucidation of RNA-protein interactions. Isotope-labeled 5-Methyluridine-3'-13C enhances the resolution of NMR spectra, enabling researchers to map binding sites and conformational changes in RNA-protein complexes. This has been particularly valuable in the design of RNA-targeted therapeutics, where understanding molecular interactions is crucial for drug efficacy.

Looking ahead, the integration of 5-Methyluridine-3'-13C with emerging technologies such as CRISPR-based gene editing and single-cell sequencing is expected to open new avenues for research. Its ability to provide precise, isotope-specific data makes it an indispensable tool for advancing our understanding of nucleic acid biology and developing next-generation therapeutics. As the field progresses, continued innovation in synthetic methodologies and analytical techniques will further enhance the utility of this compound in both basic and applied research.

• 1463-10-1(5-Methyluridine)
• 3416-05-5(3’-Deoxythymidine)
• 3424-98-4(Telbivudine)
• 55486-09-4(5-Methyl-2′-O-methyluridine)
• 3083-77-0(1-beta-D-Arabinofuranosyluracil)
• 605-23-2(1-β-D-Arabinofuranosyl-5-methyl-2,4(1H,3H)-pyrimidinedione)
• 26287-69-4(1-((2S,3S,4R,5S)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione)
• 2140-76-3(2′-O-Methyluridine)
• 58-96-8(Uridine)
• 50-89-5(Thymidine)