Cas no 473921-12-9 (Lersivirine)

Lersivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) developed for the treatment of HIV-1 infection. It exhibits potent antiviral activity by selectively binding to and inhibiting the reverse transcriptase enzyme, thereby preventing viral replication. A key advantage of Lersivirine is its favorable resistance profile, demonstrating efficacy against some HIV strains resistant to first-generation NNRTIs. Its pharmacokinetic properties include good oral bioavailability and a manageable drug-drug interaction profile. The compound's optimized molecular structure contributes to reduced toxicity compared to earlier NNRTIs, making it a promising candidate for combination antiretroviral therapy. Preclinical and clinical studies have shown its potential as a well-tolerated option for HIV treatment regimens.

Lersivirine structure

Product Name:Lersivirine

CAS No:473921-12-9

MF:C₁₇H₁₈N₄O₂

MW:310.350423336029

MDL:MFCD16619314

CID:68191

PubChem ID:16739244

Update Time:2025-06-08

Lersivirine Chemical and Physical Properties

Names and Identifiers

- 3-Cyano-5-[[3,5-diethyl-1-(2-hydroxyethyl)-1H-pyrazol-4-yl]oxy]benzonitrile
- 5-[3,5-diethyl-1-(2-hydroxyethyl)pyrazol-4-yl]oxybenzene-1,3-dicarbonitrile
- Lersivirine
- UK 453061
- 2won
- 5-((3,5-Diethyl-1-(2-hydroxyethyl)-1H-pyrazol-4-yl)oxy)benzene-1,3-dicarbonitril
- 5-{[3,5-Diethyl-1-(2-Hydroxyethyl)-1h-Pyrazol-4-Yl]oxy}benzene-1,3-Dicarbonitrile
- 5-{[3,5-diethyl-1-(2-hydroxyethyl)-1H-pyrazol-4-yl]oxy}isophthalonitrile
- Lersivirine [USAN:INN]
- UK-453061
- R3ZGC15A9A
- 5-((3,5-diethyl-1-(2-hydroxyethyl)-1H-pyrazol-4-yl)oxy)isophthalonitrile
- 5-((3,5-Diethyl-1-(2-hydroxyethyl)-1H-pyrazol-4-yl)oxy)benzene-1,3-dicarbonitrile
- ZZE
- Lersivi
- LERSIVIRINE [INN]
- NCGC00378968-01
- 5-{3,5-diethyl-1-(2hydroxyethyl)-1H-pyrazol-4-yl]isophthalonitrile
- s8055
- LERSIVIRINE [WHO-DD]
- EX-A165
- Lersivirine(UK 453061)
- CHEBI:177465
- Q27287760
- SCHEMBL508446
- 473921-12-9
- Lersivirine (UK-453061)
- CHEMBL571987
- LersivirineUK 453061
- UK-453,061
- 1,3-Benzenedicarbonitrile, 5-((3,5-diethyl-1-(2-hydroxyethyl)-1H-pyrazol-4-yl)oxy)-
- Lersivirine [USAN]
- UNII-R3ZGC15A9A
- AKOS030526818
- SB17095
- BCP08443
- Lersivirine (USAN/INN)
- BS-17083
- HY-14267
- UK 453,061
- A872162
- DB11649
- CS-1191
- D09634
- FT-0745075
- NS00068778
- DTXSID0057881
- BDBM50483552
- MFCD16619314
- LersivirineUK 453061?
- GLXC-15729
- DA-42388
- BRD-K03289534-001-01-4
- MDL： MFCD16619314
- Inchi： 1S/C17H18N4O2/c1-3-15-17(16(4-2)21(20-15)5-6-22)23-14-8-12(10-18)7-13(9-14)11-19/h7-9,22H,3-6H2,1-2H3
- InChI Key： MCPUZZJBAHRIPO-UHFFFAOYSA-N
- SMILES： O(C1C=C(C#N)C=C(C#N)C=1)C1C(CC)=NN(CCO)C=1CC

Computed Properties

Exact Mass: 310.14297583 g/mol
Monoisotopic Mass: 310.14297583 g/mol
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 5
Heavy Atom Count: 23
Rotatable Bond Count: 6
Complexity: 456
Covalently-Bonded Unit Count: 1
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count : 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
XLogP3: 2.1
Topological Polar Surface Area: 94.9
Molecular Weight: 310.35

Experimental Properties

Density: 1.19
Boiling Point: 455.382°C at 760 mmHg

Lersivirine Security Information

Signal Word：Warning
Hazard Statement： H302
Warning Statement： P280-P305+P351+P338
Storage Condition：Powder -20°C 3 years ? 4°C 2 years In solvent -80°C 6 months ? -20°C 1 month

Lersivirine Pricemore >>

Related Categories	No.	Product Name	Cas No.	Purity	Specification	Price	update time
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	L125187-50mg	Lersivirine	473921-12-9		50mg	￥6,053.00	2021-05-26
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	L125187-5mg	Lersivirine	473921-12-9		5mg	￥980.00	2021-05-26
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	L125187-10mg	Lersivirine	473921-12-9		10mg	￥1,635.00	2021-05-26
S e l l e c k ZHONG GUO	S8055-5mg	Lersivirine (UK-453061)	473921-12-9	99.50%	5mg	￥1794.19	2023-09-15
S e l l e c k ZHONG GUO	S8055-25mg	Lersivirine (UK-453061)	473921-12-9	99.50%	25mg	￥5381.22	2022-04-26
ChemScence	CS-1191-5mg	Lersivirine	473921-12-9	98.33%	5mg	$158.0	2022-04-27
ChemScence	CS-1191-10mg	Lersivirine	473921-12-9	98.33%	10mg	$264.0	2022-04-27
ChemScence	CS-1191-50mg	Lersivirine	473921-12-9	98.33%	50mg	$924.0	2022-04-27
ChemScence	CS-1191-100mg	Lersivirine	473921-12-9	98.33%	100mg	$1584.0	2022-04-27
TRC	L212825-5mg	Lersivirine	473921-12-9		5mg	$ 715.00	2022-06-04

Lersivirine Suppliers

Amadis Chemical Company Limited

Gold Member

Audited Supplier

(CAS:473921-12-9)Lersivirine

Order Number:A872162

Stock Status:in Stock

Quantity:250mg/100mg/50mg

Purity:99%

Pricing Information Last Updated:Friday, 30 August 2024 09:32

Price ($):526.0/310.0/182.0

Email:[email protected]

Product Official Link

Lersivirine Related Literature

1. Recent advances and prospects in the palladium-catalyzed cyanation of aryl halides

Mohan Neetha,C. M. A. Afsina,Thaipparambil Aneeja,Gopinathan Anilkumar RSC Adv. 2020 10 33683
2. In search of a treatment for HIV – current therapies and the role of non-nucleoside reverse transcriptase inhibitors (NNRTIs)

Chevonne Reynolds,Charles B. de Koning,Stephen C. Pelly,Willem A. L. van Otterlo,Moira L. Bode Chem. Soc. Rev. 2012 41 4657
3. “Old Dogs with New Tricks”: exploiting alternative mechanisms of action and new drug design strategies for clinically validated HIV targets

Dongwei Kang,Yu'ning Song,Wenmin Chen,Peng Zhan,Xinyong Liu Mol. BioSyst. 2014 10 1998
4. Meet the MedChemCommEditorial Board

Med. Chem. Commun. 2010 1 13
5. Advances in the development of pyridinone derivatives as non-nucleoside reverse transcriptase inhibitors

Hugo Vite-Caritino,Oscar Méndez-Lucio,Héctor Reyes,Alberto Cabrera,Daniel Chávez,José L. Medina-Franco RSC Adv. 2016 6 2119

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