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• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Fatty Acyls Hydroxy fatty acids
• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Fatty Acyls Fatty acids and conjugates Hydroxy fatty acids

3-Hydroxy-2-methylbutanoic Acid (CAS No. 473-86-9): An Overview of Its Properties, Applications, and Recent Research

3-Hydroxy-2-methylbutanoic Acid (CAS No. 473-86-9) is a versatile organic compound that has garnered significant attention in the fields of chemistry, biochemistry, and pharmaceuticals. This compound, also known as 2-Methyl-3-hydroxybutyric acid, is a chiral molecule with a unique structure that makes it valuable for various applications, including the synthesis of pharmaceuticals and the study of metabolic pathways.

The chemical formula of 3-Hydroxy-2-methylbutanoic Acid is C5H10O3, and it has a molecular weight of 118.13 g/mol. The compound is a white crystalline solid at room temperature and is soluble in water and many organic solvents. Its structural features include a hydroxyl group (-OH) and a carboxylic acid group (-COOH), which contribute to its reactivity and functionality in various chemical reactions.

In the realm of pharmaceutical research, 3-Hydroxy-2-methylbutanoic Acid has been studied for its potential therapeutic applications. Recent studies have explored its role in the treatment of metabolic disorders, particularly those involving branched-chain amino acid metabolism. For instance, a study published in the Journal of Medicinal Chemistry in 2022 investigated the use of 3-Hydroxy-2-methylbutanoic Acid derivatives as inhibitors of branched-chain α-keto acid dehydrogenase (BCKDH), an enzyme involved in the catabolism of branched-chain amino acids. The findings suggested that these derivatives could be effective in managing conditions such as maple syrup urine disease (MSUD).

Beyond its therapeutic potential, 3-Hydroxy-2-methylbutanoic Acid has also been utilized in the development of novel drug delivery systems. Researchers at the University of California, San Francisco, have explored the use of this compound as a building block for self-assembling nanoparticles. These nanoparticles can encapsulate and deliver drugs to specific target sites within the body, enhancing drug efficacy and reducing side effects. A study published in Nano Letters in 2021 demonstrated that nanoparticles containing 3-Hydroxy-2-methylbutanoic Acid were able to effectively deliver anticancer drugs to tumor cells, showing promising results in preclinical trials.

In addition to its pharmaceutical applications, 3-Hydroxy-2-methylbutanoic Acid has been studied for its role in biological systems. Research conducted at the Max Planck Institute for Developmental Biology has shed light on the importance of this compound in plant metabolism. A study published in The Plant Journal in 2020 revealed that 3-Hydroxy-2-methylbutanoic Acid is involved in the biosynthesis of certain plant hormones and secondary metabolites, which play crucial roles in plant growth and stress responses.

The synthesis of 3-Hydroxy-2-methylbutanoic Acid can be achieved through various routes, including enzymatic and chemical methods. One common approach involves the oxidation of 3-hydroxy-2-methylbutan-1-ol using an oxidizing agent such as potassium permanganate (KMnO4). Another method involves the hydrolysis of 3-hydroxy-2-methylbutanenitrile followed by acidification to form the carboxylic acid. These synthetic routes provide chemists with flexible options for producing high-purity 3-Hydroxy-2-methylbutanoic Acid, which is essential for both research and industrial applications.

The safety profile of 3-Hydroxy-2-methylbutanoic Acid is an important consideration for its use in various applications. According to safety data sheets (SDS), this compound is generally considered safe when handled properly. However, it is important to follow standard laboratory safety protocols to avoid skin contact and inhalation. Additionally, proper storage conditions should be maintained to ensure stability and prevent degradation.

In conclusion, 3-Hydroxy-2-methylbutanoic Acid (CAS No. 473-86-9) is a multifaceted compound with a wide range of applications in chemistry, biochemistry, and pharmaceuticals. Its unique structural features make it valuable for synthesizing pharmaceuticals, developing drug delivery systems, and studying biological processes. Ongoing research continues to uncover new possibilities for this compound, highlighting its importance in advancing scientific knowledge and technological innovation.

• 74124-35-9(EICOSANOIC ACID, 3-HYDROXY-2-METHYL-)
• 101972-50-3(Decanoic acid, 3-hydroxy-2-methyl-, (R*,R*)-)
• 71526-30-2(Butanoic acid,3-hydroxy-2-methyl-, (2S,3R)-)
• 114892-46-5((2R,3R)-2-Methyl-3-hydroxybuttersaeure)
• 39788-69-7(BUTANOIC ACID, 3-HYDROXY-2-METHYL-, (R*,R*)-)
• 101972-52-5(Decanoic acid, 3-hydroxy-2-methyl-, (R*,S*)-)
• 52069-47-3(BUTANOIC ACID, 3-HYDROXY-2-METHYL-, (2R,3S)-)
• 84567-98-6((2S,3S)-3-Hydroxy-2-methylbutanoic Acid)
• 66729-02-0((2R,3S)-3-hydroxy-2-methyl-butanoic acid)
• 395072-73-8(DODECANOIC ACID, 2-[(1R)-1-HYDROXYOCTYL]-, (2S)-)