• 1. Tuning of coordination geometry via cooperation of inter- and intramolecular hydrogen bonds in bis(benzoylacetonato)manganese(ii) adducts with pyridine derivatives
  Ivica Cvrtila,Vladimir Stilinovi?,Branko Kaitner CrystEngComm 2013 15 6585
• 2. Control of the photochromic behavior of cobaloxime complexes with salicylidene-3-aminopyridine and 2-cyanoethyl groups by dual photoisomerization
  Akiko Sekine,Sayaka Ina,Kohei Johmoto,Hidehiro Uekusa CrystEngComm 2016 18 7330
• 3. Ligand directed structural diversity and magnetism in copper(ii)–azido assemblies with isomeric aminopyridines: synthesis, structure, magnetism and theoretical studies
  Priyanka Pandey,Bhagwan Kharediya,Bahjat Elrez,J-P. Sutter,G. Bhargavi,M. V. Rajasekharan,Sailaja S. Sunkari Dalton Trans. 2017 46 15908
• 4. Microwave spectra and structure of the amine group in 3-aminopyridine and 4-aminopyridine. Ab initio molecular orbital calculations of the structure of the amine group in the aminopyridines
  Dines Christen,David Norbury,David G. Lister,Paolo Palmieri J. Chem. Soc. Faraday Trans. 2 1975 71 438
• 5. Fine tuning through valence bond tautomerization of ancillary ligands in ruthenium(ii) arene complexes for better anticancer activity and enzyme inhibition properties
  Poulami Mandal,Novina Malviya,M. Fátima C. Guedes da Silva,Sandeep Singh Dhankhar,C. M. Nagaraja,Shaikh M. Mobin,Suman Mukhopadhyay Dalton Trans. 2016 45 19277

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Aminopyridines and derivatives

Pyridin-3-Amine: A Comprehensive Overview

Pyridin-3-Amine, also known by its CAS number 462-08-8, is a heterocyclic aromatic compound with a pyridine ring substituted by an amino group at the 3-position. This compound has garnered significant attention in various fields due to its unique chemical properties and versatile applications. In this article, we will delve into the structural characteristics, synthesis methods, chemical properties, and recent advancements in the utilization of Pyridin-3-Amine.

The molecular structure of Pyridin-3-Amine consists of a six-membered aromatic ring with one nitrogen atom at position 1 and an amino group (-NH?) at position 3. This arrangement imparts the compound with distinct electronic properties, making it a valuable substrate in organic synthesis and material science. Recent studies have highlighted the role of Pyridin-3-Amine in the development of novel materials, such as coordination polymers and metal-organic frameworks (MOFs), where its nitrogen atoms can act as coordinating sites for metal ions.

Synthesis of Pyridin-3-Amine can be achieved through various methods, including the Curtius rearrangement, Staudinger reaction, and direct amination of pyridine derivatives. A notable advancement in this area involves the use of catalytic asymmetric synthesis to produce enantiomerically enriched Pyridin-3-Amine. This approach has been pivotal in drug discovery, where stereochemistry plays a critical role in biological activity.

The chemical reactivity of Pyridin-3-Amine is influenced by the electron-withdrawing effect of the amino group, which activates the pyridine ring towards electrophilic substitution reactions. Recent research has explored its application as a precursor for synthesizing bioactive molecules, such as kinase inhibitors and GPCR modulators. For instance, derivatives of Pyridin-3-Amine have shown promise in targeting specific enzymes associated with neurodegenerative diseases.

In terms of applications, Pyridin-3-Amine finds utility in pharmaceuticals, agrochemicals, and specialty chemicals. Its ability to form stable complexes with metal ions has led to its use in catalysis and sensing technologies. For example, researchers have developed sensors based on Pyridin-3-Amine-functionalized nanoparticles for detecting heavy metals in environmental samples.

The interaction between Pyridin-3-Amine and biological systems has been extensively studied. Computational modeling techniques have provided insights into its binding affinity with proteins and nucleic acids, paving the way for rational drug design strategies. Additionally, green chemistry approaches have been employed to optimize the synthesis and purification processes of Pyridin-3-Amine, reducing environmental impact while maintaining high yields.

In conclusion, Pyridin-3-Amine, with its CAS number 462-08-8, stands as a versatile building block in organic chemistry. Its unique properties and diverse applications continue to drive innovation across multiple disciplines. As research progresses, we can expect further breakthroughs that leverage the potential of this compound in addressing challenges in medicine, materials science, and beyond.

• 23687-25-4(isoquinolin-4-amine)
• 30146-41-9(3,4,5-Pyridinetriamine,hydrochloride (1:2))
• 29212-49-5(1H-Pyrrol-3-amine)
• 1423031-91-7(Isoquinolin-4-amine hydrochloride)
• 54-96-6(Amifampridine)
• 4318-78-9(3,5-Diaminopyridine)
• 18364-47-1(N-Methylpyridin-3-amine)
• 4318-76-7(2,5-Diaminopyridine)
• 618439-82-0(3,4,5-Triaminopyridine)
• 1219805-61-4(3-AMINOPYRIDINE-D6)