Production Method 1

71740-33-5

455-19-6

90390-11-7

Reaction Conditions

1.1 Reagents: 1-Bromo-1-propene ,  Propanoic acid, 2,2-dimethyl-, sodium salt (1:1) Catalysts: Nickel chloride hexahydrate ,  4,4′-Bis(1,1-dimethylethyl)-2,2′-bipyridine ,  Benzonitrile, 2,3,4,5,6-penta-9H-carbazol-9-yl- Solvents: Acetonitrile ,  Water ;  8 - 30 h, rt

Reference

Photoinduced Nickel-Catalyzed Selective N-Demethylation of Trialkylamines Using C(sp2)-Bromides as HAT Reagents

Zhang, Xiao ; et al, Journal of the American Chemical Society, 2023, 145(6), 3294-3300

Production Method 2

168013-75-0

455-19-6

80277-40-3

Reaction Conditions

1.1 Catalysts: Ruthenium(1+), (η6-benzene)chloro[1,2-ethanediylbis[diphenylphosphine-κP]]-, chl… Solvents: Benzene ;  24 h, rt → 120 °C

Reference

Acceptorless and Base-free Dehydrogenation of Cyanohydrin with (η6-Arene)halide(Bidentate Phosphine)ruthenium(II) Complex

Kim, Kicheol; et al, Advanced Synthesis & Catalysis, 2017, 359(19), 3292-3298

Production Method 3

402-49-3

455-19-6

90390-11-7

Reaction Conditions

1.1 Solvents: Diethyl ether ,  Water ;  12 h, rt
2.1 Reagents: 1-Bromo-1-propene ,  Propanoic acid, 2,2-dimethyl-, sodium salt (1:1) Catalysts: Nickel chloride hexahydrate ,  4,4′-Bis(1,1-dimethylethyl)-2,2′-bipyridine ,  Benzonitrile, 2,3,4,5,6-penta-9H-carbazol-9-yl- Solvents: Acetonitrile ,  Water ;  8 - 30 h, rt

Reference

Photoinduced Nickel-Catalyzed Selective N-Demethylation of Trialkylamines Using C(sp2)-Bromides as HAT Reagents

Zhang, Xiao ; et al, Journal of the American Chemical Society, 2023, 145(6), 3294-3300

Production Method 4

455-19-6

455-19-6

80277-40-3

Reaction Conditions

1.1 Reagents: Sodium bisulfite Solvents: Ethyl acetate ,  Water ;  20 h, 40 °C
2.1 Catalysts: Ruthenium(1+), (η6-benzene)chloro[1,2-ethanediylbis[diphenylphosphine-κP]]-, chl… Solvents: Benzene ;  24 h, rt → 120 °C

Reference

Acceptorless and Base-free Dehydrogenation of Cyanohydrin with (η6-Arene)halide(Bidentate Phosphine)ruthenium(II) Complex

Kim, Kicheol; et al, Advanced Synthesis & Catalysis, 2017, 359(19), 3292-3298

4-(Trifluoromethyl)benzaldehyde Raw materials

• 2-hydroxy-2-4-(trifluoromethyl)phenylacetonitrile
• 4-(Trifluoromethyl)benzaldehyde
• 1-(Bromomethyl)-4-(trifluoromethyl)benzene
• Benzenemethanamine, N,N-dimethyl-4-(trifluoromethyl)-

4-(Trifluoromethyl)benzaldehyde Preparation Products

• N-methyl-1-[4-(trifluoromethyl)phenyl]methanamine (90390-11-7)
• 4-(Trifluoromethyl)benzaldehyde (455-19-6)
• 2-(4-(Trifluoromethyl)phenyl)-2-oxoacetonitrile (80277-40-3)

• 1. Environmentally benign and diastereoselective synthesis of 2,4,5-trisubstituted-2-imidazolines
  Hai Anh Le Phuong,Levente Cseri,George F. S. Whitehead,Arthur Garforth,Peter Budd,Gyorgy Szekely RSC Adv. 2017 7 53278
• 2. Synthesis of plasmodione metabolites and 13C-enriched plasmodione as chemical tools for drug metabolism investigation
  Liwen Feng,Don Antoine Lanfranchi,Leandro Cotos,Elena Cesar-Rodo,Katharina Ehrhardt,Alice-Anne Goetz,Herbert Zimmermann,Fran?ois Fenaille,Stephanie A. Blandin,Elisabeth Davioud-Charvet Org. Biomol. Chem. 2018 16 2647
• 3. Continuous flow for enantioselective cyanohydrin synthesis
  Dominika Stradomska,José Coloma,Ulf Hanefeld,Katarzyna Szymańska Catal. Sci. Technol. 2022 12 3356
• 4. Dioxomolybdenum(vi) complexes as catalysts for the hydrosilylation of aldehydes and ketones
  Patrícia M. Reis,Carlos C. Rom?o,Beatriz Royo Dalton Trans. 2006 1842
• 5. New low band gap 2-(4-(trifluoromethyl)phenyl)-1H-benzo[d]imidazole and benzo[1,2-c;4,5-c′]bis[1,2,5]thiadiazole based conjugated polymers for organic photovoltaics
  M. G. Murali,Arun D. Rao,Praveen C. Ramamurthy RSC Adv. 2014 4 44902

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Trifluoromethylbenzenes
• Solvents and Organic Chemicals Organic Compounds Aldehyde/Ketone

Professional Introduction to 4-(Trifluoromethyl)benzaldehyde (CAS No. 455-19-6)

4-(Trifluoromethyl)benzaldehyde (CAS No. 455-19-6) is a highly valuable intermediate in the field of organic synthesis and pharmaceutical chemistry. Its unique structural features, characterized by the presence of a trifluoromethyl group, make it a compound of significant interest for researchers and industrial applications. This introduction provides a comprehensive overview of the compound's properties, applications, and recent advancements in its utilization within the pharmaceutical and chemical industries.

The trifluoromethyl group attached to the benzaldehyde core imparts unique electronic and steric properties to the molecule. This modification enhances the lipophilicity and metabolic stability of derivatives, making 4-(trifluoromethyl)benzaldehyde a preferred building block in drug design. The compound's ability to serve as a precursor for various pharmacologically active agents has been extensively explored in recent years.

In the realm of pharmaceutical research, 4-(trifluoromethyl)benzaldehyde has been utilized in the synthesis of novel therapeutic agents targeting a wide range of diseases. Its incorporation into drug molecules often leads to improved pharmacokinetic profiles, including enhanced bioavailability and prolonged half-life. Recent studies have highlighted its role in developing antiviral and anticancer agents, where the trifluoromethyl group plays a crucial role in modulating receptor binding affinity and metabolic resistance.

The compound's reactivity also makes it a valuable tool in synthetic chemistry. It serves as a key intermediate in the preparation of complex heterocyclic compounds, which are prevalent in many modern drugs. The presence of the aldehyde functionality allows for further derivatization through condensation reactions, enabling the construction of diverse molecular architectures. These synthetic pathways have been instrumental in generating novel scaffolds with potential therapeutic applications.

Recent advancements in green chemistry have also leveraged 4-(trifluoromethyl)benzaldehyde for more sustainable synthetic routes. Researchers have developed catalytic methods that minimize waste and energy consumption while maintaining high yields. Such innovations align with the growing emphasis on environmentally friendly practices in chemical manufacturing, ensuring that the production of this valuable intermediate remains both efficient and sustainable.

The pharmaceutical industry continues to explore new applications for 4-(trifluoromethyl)benzaldehyde, particularly in the development of next-generation therapeutics. Its versatility as a building block has led to its inclusion in numerous clinical trials, where it is being evaluated for its efficacy against various diseases. The compound's ability to enhance drug potency and selectivity makes it an attractive candidate for further investigation.

Beyond pharmaceuticals, 4-(trifluoromethyl)benzaldehyde finds applications in agrochemicals and specialty chemicals. Its derivatives are used as intermediates in the synthesis of pesticides and herbicides, where the trifluoromethyl group contributes to improved stability and efficacy. Additionally, it serves as a precursor in fine chemical synthesis, contributing to the production of dyes, polymers, and other industrial materials.

The future prospects for 4-(trifluoromethyl)benzaldehyde remain promising, with ongoing research aimed at uncovering new synthetic strategies and expanding its utility across multiple industries. As computational chemistry advances, virtual screening methods are being employed to identify novel derivatives with enhanced properties. These efforts are expected to yield innovative applications that further solidify the compound's importance in modern chemistry.

In conclusion, 4-(trifluoromethyl)benzaldehyde (CAS No. 455-19-6) is a multifaceted compound with broad applications in pharmaceuticals, agrochemicals, and specialty chemicals. Its unique structural features and reactivity make it an indispensable tool for researchers seeking to develop novel therapeutics and advanced materials. As scientific understanding continues to evolve, the compound's role is likely to expand even further, driving innovation across multiple sectors.

• 454-89-7(3-(Trifluoromethyl)benzaldehyde)
• 401-95-6(3,5-Bis(trifluoromethyl)benzaldehyde)
• 46061-29-4(Methylium, oxo[4-(trifluoromethyl)phenyl]- (9CI))
• 55805-29-3(4-(difluoromethyl)benzaldehyde)
• 477535-14-1(3,4-Bis(trifluoromethyl)benzaldehyde)
• 945004-44-4(3-(Difluoromethyl)benzaldehyde)
• 951232-01-2(3-Methyl-4-(trifluoromethyl)benzaldehyde)
• 92270-09-2(Methylium, [3,5-bis(trifluoromethyl)phenyl]oxo-)
• 46060-47-3(Methylium, oxo[3-(trifluoromethyl)phenyl]-)
• 116070-39-4(3-methyl-5-(trifluoromethyl)benzaldehyde)