• 1. Ester-mediated peptide formation promoted by deep eutectic solvents: a facile pathway to proto-peptides?
  Chen-Yu Chien,Sheng-Sheng Yu Chem. Commun., 2020,56, 11949-11952
• 2. Emerging enantiomeric resolution materials with homochiral nano-fabrications
  Ji-Ping Wei Nanoscale, 2015,7, 11815-11832
• 3. Excellent energy storage performance in NaNbO3-based relaxor antiferroeic ceramics under a low electric field
  XuxinCheng,XiaomingChen,PengyuanFan
• 4. Enabling shape memory and healable effects in a conjugated polymer by incorporating siloxane via dynamic imine bond?
  Yaling Zhang,Chunhui Dai,Shiwei Zhou,Bin Liu Chem. Commun., 2018,54, 10092-10095
• 5. Fate of Sb(v) and Sb(iii) species along a gradient of pH and oxygen concentration in the Carnoulès mine waters (Southern France)
  Eléonore Resongles,Corinne Casiot,Fran?oise Elbaz-Poulichet,Rémi Freydier,Odile Bruneel,Christine Piot,Sophie Delpoux,Aurélie Volant,Angélique Desoeuvre Environ. Sci.: Processes Impacts, 2013,15, 1536-1544

Comprehensive Guide to 1H-Triazole-4,5-dicarboxylic Acid (CAS No. 4546-95-6): Properties, Applications, and Market Insights

1H-Triazole-4,5-dicarboxylic acid (CAS No. 4546-95-6) is a versatile heterocyclic compound that has gained significant attention in pharmaceutical, agrochemical, and material science research. This triazole derivative features two carboxylic acid groups at the 4 and 5 positions, making it a valuable building block for various synthetic applications. The compound's molecular formula is C₄H₃N₃O₄, with a molecular weight of 157.09 g/mol.

The growing interest in 1H-triazole-4,5-dicarboxylic acid applications stems from its unique chemical properties. Researchers have identified this compound as a crucial intermediate in the synthesis of biologically active molecules, particularly in the development of novel antifungal agents and anticancer drugs. Its ability to form stable coordination complexes with metal ions also makes it valuable in coordination chemistry and material science applications.

Recent studies highlight the potential of 4546-95-6 compound in addressing current challenges in drug discovery. With the increasing demand for new antimicrobial compounds to combat drug-resistant pathogens, this triazole carboxylic acid derivative offers promising structural features that can be modified to enhance biological activity. The compound's hydrogen bonding capacity and metal chelating properties make it particularly interesting for designing enzyme inhibitors.

In material science, 1H-triazole-4,5-dicarboxylic acid synthesis has opened new possibilities for developing functional materials. The compound serves as a precursor for creating metal-organic frameworks (MOFs) with potential applications in gas storage, catalysis, and sensing technologies. Researchers are particularly excited about its role in developing porous materials for carbon capture applications, addressing current environmental concerns.

The physical properties of 1H-triazole-4,5-dicarboxylic acid contribute to its wide applicability. Typically appearing as a white to off-white crystalline powder, it demonstrates moderate solubility in water and polar organic solvents. The compound's thermal stability and pH-dependent solubility make it suitable for various industrial processes. These characteristics are crucial for researchers working on green chemistry approaches and sustainable synthesis methods.

Market analysis indicates growing demand for CAS 4546-95-6 across multiple sectors. The pharmaceutical industry remains the primary consumer, driven by the need for new drug scaffolds and bioactive intermediates. Additionally, the compound's applications in advanced materials and coordination polymers are creating new market opportunities. Suppliers are responding to this demand by improving triazole derivative production methods and scaling up manufacturing capabilities.

Quality control is paramount when working with 1H-triazole-4,5-dicarboxylic acid. Reputable suppliers typically provide the compound with ≥98% purity, verified by HPLC analysis and spectroscopic characterization. Proper storage conditions (typically 2-8°C in a dry environment) are essential to maintain the compound's stability and prevent degradation. Researchers should always verify the CAS number 4546-95-6 when sourcing this material to ensure they obtain the correct chemical entity.

Recent innovations in triazole-4,5-dicarboxylic acid chemistry have focused on developing more efficient synthetic routes. Traditional methods involving oxidative cleavage of benzene derivatives are being replaced by more sustainable approaches using catalytic processes and microwave-assisted synthesis. These advancements not only improve yields but also align with the growing emphasis on environmentally friendly synthesis in the chemical industry.

The safety profile of 1H-triazole-4,5-dicarboxylic acid makes it attractive for industrial applications. While standard laboratory precautions should always be followed, the compound is not classified as highly hazardous under normal handling conditions. This characteristic facilitates its use in various research settings and industrial processes without requiring specialized containment measures, unlike many other heterocyclic compounds with similar applications.

Future research directions for CAS 4546-95-6 include exploring its potential in bioconjugation chemistry and drug delivery systems. The compound's ability to form stable linkages with biomolecules while maintaining biological activity makes it particularly promising for developing targeted therapies and diagnostic agents. Additionally, its applications in creating smart materials responsive to environmental stimuli represent an exciting frontier in materials science.

For researchers considering working with 1H-triazole-4,5-dicarboxylic acid, several key resources are available. The scientific literature contains numerous references to its synthesis and applications, particularly in journals focusing on medicinal chemistry and coordination compounds. Several patent applications describe innovative uses of this triazole carboxylic acid derivative, highlighting its commercial potential. Regular updates from chemical suppliers about availability and pricing can help research teams plan their projects effectively.

In conclusion, 1H-triazole-4,5-dicarboxylic acid (CAS No. 4546-95-6) represents a versatile and valuable compound with wide-ranging applications across multiple scientific disciplines. Its unique structural features, combined with favorable physicochemical properties, make it an important building block for pharmaceutical development, material science innovation, and coordination chemistry research. As scientific understanding of this compound continues to grow, we can anticipate even more innovative applications emerging in the coming years, particularly in areas addressing current global challenges in healthcare and environmental sustainability.

• 707-94-8(4,5-dimethyl 1H-1,2,3-triazole-4,5-dicarboxylate)
• 4343-73-1(ethyl 5-methyl-1H-1,2,3-triazole-4-carboxylate)
• 55357-63-6(1H-1,2,3-Triazole-4,5-dicarboxylic acid, diethyl ester)
• 60419-70-7(Methyl 5-methyl-1H-1,2,3-triazole-4-carboxylate)
• 89166-02-9(4-methyl-1H-1,2,3-triazole-5-carboxylic acid)
• 4967-77-5(Methyl 1H-1,2,3-triazole-4-carboxylate)
• 877309-59-6(Methyl 2H-1,2,3-triazole-4-carboxylate)
• 16681-70-2(1H-1,2,3-Triazole-4-carboxylic acid)
• 294853-04-6(2H-1,2,3-Triazole-4,5-dicarboxylicacid)
• 507473-06-5(Ethyl 5-methyl-1H-1,2,3-triazole-4-carboxylate)