• 1. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
  Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119
• 2. Enabling chloride salts for thermal energy storage: implications of salt purity?
  J. Matthew Kurley,Phillip W. Halstenberg,Abbey McAlister,Stephen Raiman,Richard T. Mayes RSC Adv., 2019,9, 25602-25608
• 3. Ester-mediated peptide formation promoted by deep eutectic solvents: a facile pathway to proto-peptides?
  Chen-Yu Chien,Sheng-Sheng Yu Chem. Commun., 2020,56, 11949-11952
• 4. Evidence of pre-micellar aggregates in aqueous solution of amphiphilic PDMS–PEO block copolymer?
  Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991
• 5. Excellent mechanical performance and enhanced dielectric properties of OBC/SiO2 elastomeric nanocomposites: effect of dispersion of the SiO2 nanoparticles?
  Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305

• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenols Halophenols Fluorophenols
• Solvents and Organic Chemicals Organic Compounds Alcohol/Ether
• Solvents and Organic Chemicals Organic Compounds Hydrocarbons

Research Brief on 3-Bromo-5-fluorophenol (CAS: 433939-27-6) in Chemical Biology and Pharmaceutical Applications

3-Bromo-5-fluorophenol (CAS: 433939-27-6) is a halogenated phenol derivative that has garnered significant attention in recent chemical biology and pharmaceutical research due to its versatile applications as a building block in organic synthesis and drug development. This compound, characterized by the presence of both bromine and fluorine substituents on the aromatic ring, exhibits unique electronic and steric properties that make it valuable for the design of bioactive molecules. Recent studies have explored its utility in the synthesis of kinase inhibitors, antimicrobial agents, and radiopharmaceutical precursors, highlighting its broad potential in medicinal chemistry.

A 2023 study published in the Journal of Medicinal Chemistry demonstrated the use of 3-Bromo-5-fluorophenol as a key intermediate in the synthesis of novel Bruton's tyrosine kinase (BTK) inhibitors. The researchers leveraged the bromine atom for Suzuki-Miyaura cross-coupling reactions, while the fluorine atom contributed to enhanced metabolic stability of the final compounds. The resulting inhibitors showed promising activity against resistant forms of BTK, suggesting potential applications in treating B-cell malignancies.

In the field of antimicrobial research, a team from the University of Cambridge reported in Bioorganic & Medicinal Chemistry Letters (2024) that derivatives synthesized from 3-Bromo-5-fluorophenol exhibited potent activity against multidrug-resistant Staphylococcus aureus strains. The presence of both halogen atoms was found to be crucial for membrane penetration and target binding, with the fluorine atom particularly important for reducing cytotoxicity against mammalian cells.

Recent advances in radiopharmaceutical development have also utilized 3-Bromo-5-fluorophenol as a precursor for ¹⁸F-labeled compounds. A 2024 study in Nuclear Medicine and Biology described an efficient two-step radiosynthesis approach where the bromine atom served as a leaving group for nucleophilic aromatic substitution with [¹⁸F]fluoride, enabling the production of PET tracers for neuroinflammation imaging with high radiochemical yields (>85%).

From a chemical biology perspective, researchers at Scripps Research Institute have employed 3-Bromo-5-fluorophenol in the development of activity-based protein profiling (ABPP) probes. The compound's ability to serve as a warhead in covalent inhibitor design was highlighted in a 2023 ACS Chemical Biology publication, where it was incorporated into probes targeting cysteine proteases involved in cancer progression.

Ongoing research continues to explore new applications for 3-Bromo-5-fluorophenol, with particular focus on its use in PROTAC (Proteolysis Targeting Chimera) design and as a building block for DNA-encoded libraries. The compound's commercial availability and well-characterized reactivity profile make it an attractive starting material for diverse pharmaceutical applications. Future directions may include optimization of its physicochemical properties for improved drug-likeness and exploration of its potential in targeted drug delivery systems.

• 344-20-7(2,6-Dibromo-4-fluorophenol)
• 2105-94-4(4-Bromo-2-fluorophenol)
• 112204-58-7(5-Bromo-2-fluorophenol)
• 147460-41-1(2-Bromo-5-fluorophenol)
• 121219-03-2(4-bromo-3-fluoro-phenol)
• 104197-13-9(4-Bromo-2,6-difluorophenol)
• 27407-11-0(3-Bromo-4-fluorophenol)
• 29578-39-0(1-bromo-3-fluoro-5-methoxybenzene)
• 496-69-5(2-Bromo-4-fluorophenol)
• 166281-37-4(2-Bromo-4,5-difluorophenol)