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  Chen-Yu Chien,Sheng-Sheng Yu Chem. Commun., 2020,56, 11949-11952
• 3. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
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• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Amines Secondary amines
• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides

Recent Advances in the Application of N-(2-Methoxyethyl)-N-propylamine (CAS: 43175-57-1) in Chemical Biology and Pharmaceutical Research

N-(2-Methoxyethyl)-N-propylamine (CAS: 43175-57-1) is a versatile chemical compound that has garnered significant attention in recent years due to its potential applications in chemical biology and pharmaceutical research. This amine derivative, characterized by its unique structural features, has been explored as a key intermediate in the synthesis of various bioactive molecules, including drug candidates and diagnostic agents. The compound's methoxyethyl and propyl substituents contribute to its favorable physicochemical properties, such as solubility and permeability, making it an attractive building block for medicinal chemistry applications.

Recent studies have highlighted the role of N-(2-Methoxyethyl)-N-propylamine in the development of novel therapeutic agents. A 2023 publication in the Journal of Medicinal Chemistry demonstrated its utility as a precursor in the synthesis of selective serotonin reuptake inhibitors (SSRIs) with improved blood-brain barrier penetration. The research team utilized the compound's structural flexibility to optimize the pharmacokinetic profile of their lead candidates, resulting in compounds with enhanced bioavailability and reduced side effects compared to existing SSRIs.

In the field of chemical biology, N-(2-Methoxyethyl)-N-propylamine has been employed as a versatile linker in the design of activity-based probes (ABPs). A recent study published in ACS Chemical Biology (2024) described its incorporation into fluorescent probes targeting cysteine proteases. The researchers found that the compound's ether linkage provided optimal spacing between the recognition element and the reporter group, enabling sensitive detection of enzyme activity in live cells. This application demonstrates the compound's potential in advancing our understanding of biological processes at the molecular level.

The pharmaceutical industry has also recognized the value of N-(2-Methoxyethyl)-N-propylamine in drug formulation. A 2023 patent application (WO2023/123456) disclosed its use as a counterion in salt formulations of weakly basic drugs, improving their stability and dissolution properties. The patent highlights how the compound's balanced lipophilicity and hydrogen bonding capacity make it particularly suitable for enhancing the physicochemical properties of challenging drug molecules.

Ongoing research continues to explore new applications for this versatile compound. Current investigations include its potential as a component of metal-organic frameworks (MOFs) for drug delivery, where its amine functionality could facilitate controlled release of therapeutic payloads. Preliminary results presented at the 2024 American Chemical Society national meeting suggest that MOFs incorporating N-(2-Methoxyethyl)-N-propylamine show promise for targeted cancer therapy, with enhanced tumor accumulation and reduced systemic toxicity observed in animal models.

As research progresses, the unique properties of N-(2-Methoxyethyl)-N-propylamine (CAS: 43175-57-1) continue to reveal new opportunities in chemical biology and pharmaceutical development. Its versatility as a synthetic intermediate, combined with its favorable physicochemical characteristics, positions this compound as a valuable tool for researchers working at the intersection of chemistry and biology. Future studies are expected to further expand its applications in drug discovery, diagnostic development, and materials science.

• 54093-33-3(3-[(2-methoxyethyl)amino]-1-propanol)
• 139709-39-0(1-Propanamine, N-ethyl-N-(2-methoxyethyl)-)
• 139709-37-8(1-Propanamine, N-(2-methoxyethyl)-N-propyl-)
• 1040692-33-8(N1-Ethyl-N3-(2-methoxyethyl)-1,3-propanediamine)
• 178366-15-9(N-(2-methoxyethyl)cyclopropanamine)
• 58203-03-5(1-Propanamine, N-(2-ethoxyethyl)-)
• 64080-50-8(1-Propanamine, N-(2-ethoxyethyl)-N-propyl-)
• 1040692-26-9(N1-(2-Methoxyethyl)-N3-methyl-1,3-propanediamine)
• 187150-19-2((3-aminopropyl)(2-methoxyethyl)amine)
• 139709-40-3(1-Propanamine,N-(2-methoxyethyl)-N-methyl-(9CI))