Cas no 4279-74-7 (Benzenesulfonamide, 4-chloro-N-(4-methylphenyl)-)

4-Chloro-N-(4-methylphenyl)benzenesulfonamide is a sulfonamide derivative characterized by its chloro and methylphenyl substituents, which impart distinct chemical and physical properties. This compound is of interest in organic synthesis and pharmaceutical research due to its potential as an intermediate in the development of bioactive molecules. Its benzenesulfonamide core offers stability and reactivity, while the 4-chloro and 4-methylphenyl groups enhance its utility in selective functionalization reactions. The compound's well-defined structure and purity make it suitable for applications in medicinal chemistry, particularly in the design of sulfonamide-based therapeutics. Its solubility and compatibility with common organic solvents further facilitate its use in laboratory-scale and industrial processes.
Benzenesulfonamide, 4-chloro-N-(4-methylphenyl)- structure
4279-74-7 structure
Product Name:Benzenesulfonamide, 4-chloro-N-(4-methylphenyl)-
CAS No:4279-74-7
MF:C13H12ClNO2S
MW:281.757881164551
CID:1517233
PubChem ID:722853
Update Time:2025-11-02

Benzenesulfonamide, 4-chloro-N-(4-methylphenyl)- Chemical and Physical Properties

Names and Identifiers

    • Benzenesulfonamide, 4-chloro-N-(4-methylphenyl)-
    • CHEMBL180683
    • UPCMLD0ENAT0400-0212:001
    • 4279-74-7
    • AKOS000727630
    • AB00080648-01
    • SCHEMBL7585555
    • SR-01000395734
    • SR-01000395734-1
    • STL445412
    • 4-CHLORO-N-(4-METHYLPHENYL)BENZENE-1-SULFONAMIDE
    • Cambridge id 5321734
    • Z45633609
    • 4-chloro-N-(4-methylphenyl)benzenesulfonamide
    • Inchi： 1S/C13H12ClNO2S/c1-10-2-6-12(7-3-10)15-18(16,17)13-8-4-11(14)5-9-13/h2-9,15H,1H3
    • InChI Key： XXXCKIVSPGWSOF-UHFFFAOYSA-N
    • SMILES： ClC1C=CC(=CC=1)S(NC1C=CC(C)=CC=1)(=O)=O

Computed Properties

  • Exact Mass: 281.02786
  • Monoisotopic Mass: 281.0277275g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 18
  • Rotatable Bond Count: 3
  • Complexity: 350
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 3.4
  • Topological Polar Surface Area: 54.6?2

Experimental Properties

  • PSA: 46.17

Benzenesulfonamide, 4-chloro-N-(4-methylphenyl)- Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
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Benzenesulfonamide, 4-chloro-N-(4-methylphenyl)- Related Literature

Additional information on Benzenesulfonamide, 4-chloro-N-(4-methylphenyl)-

Comprehensive Overview of Benzenesulfonamide, 4-chloro-N-(4-methylphenyl)- (CAS No. 4279-74-7)

Benzenesulfonamide, 4-chloro-N-(4-methylphenyl)- (CAS No. 4279-74-7) is a specialized organic compound widely recognized in the chemical and pharmaceutical industries. This compound belongs to the sulfonamide family, which is known for its diverse applications in medicinal chemistry, material science, and industrial processes. The unique structure of this molecule, featuring a chloro and a methylphenyl substituent, makes it a valuable intermediate in synthetic chemistry.

The growing interest in 4-chloro-N-(4-methylphenyl)benzenesulfonamide is driven by its potential applications in drug development and agrochemical formulations. Researchers are particularly intrigued by its role as a building block for designing novel sulfonamide-based therapeutics, which are increasingly explored for their antimicrobial and anti-inflammatory properties. The compound's molecular stability and reactivity also make it a candidate for advanced material synthesis, such as polymers and coatings.

In recent years, the demand for Benzenesulfonamide derivatives has surged due to their versatility in organic synthesis. The 4-chloro-N-(4-methylphenyl) variant is often highlighted in scientific literature for its efficient synthesis routes and high purity yields. This compound is typically synthesized through nucleophilic substitution reactions, where 4-chlorobenzenesulfonyl chloride reacts with 4-methylaniline under controlled conditions. The process is optimized to ensure minimal byproducts and maximum efficiency.

One of the most discussed topics in the context of CAS 4279-74-7 is its environmental and safety profile. Regulatory bodies and industry stakeholders emphasize the importance of handling this compound with appropriate safety measures, although it is not classified as a hazardous material. Proper storage conditions, such as avoiding prolonged exposure to moisture and high temperatures, are recommended to maintain its stability. Researchers and manufacturers are also exploring greener synthesis methods to align with global sustainability goals.

The pharmaceutical industry has shown significant interest in 4-chloro-N-(4-methylphenyl)benzenesulfonamide due to its potential as a precursor for bioactive molecules. Recent studies suggest its utility in developing enzyme inhibitors, particularly targeting carbonic anhydrases, which are implicated in various diseases. This aligns with the current trend of repurposing existing chemical scaffolds for new therapeutic applications, a strategy that reduces development time and costs.

From a commercial perspective, the market for Benzenesulfonamide, 4-chloro-N-(4-methylphenyl)- is expanding, with key suppliers offering high-purity grades for research and industrial use. The compound is often listed under alternative names such as p-tolyl-4-chlorobenzenesulfonamide, which helps in broader catalog searches. Pricing and availability are influenced by factors like raw material costs and regional demand, with Asia-Pacific emerging as a significant production hub.

In conclusion, Benzenesulfonamide, 4-chloro-N-(4-methylphenyl)- (CAS No. 4279-74-7) represents a critical intermediate in modern chemistry, bridging gaps between academic research and industrial applications. Its structural features and reactivity profile continue to inspire innovations across multiple sectors, making it a compound of enduring relevance. As scientific advancements unfold, this molecule is poised to play an even greater role in addressing contemporary challenges in health and technology.

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