Production Method 1

59-30-3

4271-30-1

150-13-0

948-60-7

712-30-1

Reaction Conditions

1.1 Solvents: Water ;  8 h

Reference

Possible role of hydroxyl radicals in the oxidative degradation of folic acid

Patro, Birija S.; Adhikari, Soumyakanti; Mukherjee, Tulsi; Chattopadhyay, Subrata, Bioorganic & Medicinal Chemistry Letters, 2005, 15(1), 67-71

(4-Aminobenzoyl)-L-glutamic acid Raw materials

• Folic acid

(4-Aminobenzoyl)-L-glutamic acid Preparation Products

• sunbrella (150-13-0)
• Pterine-6-carboxylic Acid (948-60-7)
• 6-Pteridinecarboxaldehyde,2-amino-3,4-dihydro-4-oxo- (712-30-1)
• (4-Aminobenzoyl)-L-glutamic acid (4271-30-1)

• 1. The synthesis of folic acid, multiply labelled with stable isotopes, for bio-availability studies in human nutrition
  Peter Maunder,Paul M. Finglas,Anthony I. Mallet,Fred A. Mellon,M. Aaqib Razzaque,Brian Ridge,Liisa Vahteristo,Cornelia Witth?ft J. Chem. Soc. Perkin Trans. 1 1999 1311
• 2. A facile preparation method for new two-component supramolecular hydrogels and their performances in adsorption, catalysis, and stimuli-response
  Junlin Zhu,Ran Wang,Rui Geng,Xuan Zhang,Fan Wang,Tifeng Jiao,Jingyue Yang,Zhenhua Bai,Qiuming Peng RSC Adv. 2019 9 22551
• 3. Mechanism of photooxidation of folic acid sensitized by unconjugated pterins
  M. Laura Dántola,M. Paula Denofrio,Beatriz Zurbano,Carlos S. Gimenez,Peter R. Ogilby,Carolina Lorente,Andrés H. Thomas Photochem. Photobiol. Sci. 2010 9 1604
• 4. An approach for quantitative analysis of vitamins D and B9 and their metabolites in human biofluids by on-line orthogonal sample preparation and sequential mass spectrometry detection
  Carlos Ferreiro-Vera,Feliciano Priego-Capote,María Dolores Luque de Castro Analyst 2013 138 2146
• 5. Unexpected photoactivation pathways in a folate-receptor-targeted trans-diazido Pt(iv) anticancer pro-drug
  Albert Gandioso,Anna Rovira,Huayun Shi,Peter J. Sadler,Vicente Marchán Dalton Trans. 2020 49 11828

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

Introduction to (4-Aminobenzoyl)-L-glutamic Acid and Its Significance in Modern Research

Compound with the CAS number 4271-30-1, known as (4-Aminobenzoyl)-L-glutamic acid, represents a compound of considerable interest in the field of pharmaceutical and biochemical research. This molecule, characterized by its unique structural features, has garnered attention due to its potential applications in various scientific domains. The combination of an aminobenzoyl group and a glutamic acid moiety endows it with specific chemical properties that make it a valuable candidate for further exploration.

The structural composition of (4-Aminobenzoyl)-L-glutamic acid is pivotal in understanding its behavior and utility. The presence of the aminobenzoyl group, which is derived from benzoic acid, introduces a polar and aromatic component to the molecule. This feature enhances its solubility in polar solvents and contributes to its interaction with biological molecules. On the other hand, the glutamic acid moiety, an amino acid commonly found in proteins, adds a negatively charged carboxyl group, which influences the molecule's overall charge and reactivity.

In recent years, there has been a growing interest in exploring the pharmacological properties of compounds that incorporate both aromatic and amino acid functionalities. Such molecules are often investigated for their potential as drug candidates or as tools in biochemical research. The specific arrangement of functional groups in (4-Aminobenzoyl)-L-glutamic acid makes it an intriguing subject for studying enzyme interactions, receptor binding, and cellular signaling pathways.

One of the most compelling aspects of this compound is its potential application in the development of novel therapeutic agents. Researchers have been particularly interested in its ability to modulate biological processes due to its dual functionality. The aminobenzoyl group can serve as a recognition element that interacts with specific targets, while the glutamic acid moiety can influence the compound's pharmacokinetic properties. This balance of structural features makes it a promising candidate for further development.

Recent studies have highlighted the importance of understanding the molecular interactions that govern biological processes. (4-Aminobenzoyl)-L-glutamic acid has been investigated for its potential role in modulating various biological pathways, including those involved in inflammation and neurodegeneration. Its ability to interact with enzymes and receptors has been explored through both computational modeling and experimental techniques. These studies have provided valuable insights into how this compound might be utilized in therapeutic contexts.

The synthesis of (4-Aminobenzoyl)-L-glutamic acid is another area of active research. The development of efficient synthetic routes is crucial for producing sufficient quantities of the compound for both laboratory studies and potential clinical applications. Advances in synthetic chemistry have enabled researchers to access this molecule with greater ease, facilitating further exploration of its properties and applications.

In addition to its pharmacological potential, (4-Aminobenzoyl)-L-glutamic acid has shown promise as a tool in biochemical research. Its unique structure allows it to be used as a substrate or inhibitor in enzymatic assays, helping researchers understand the mechanisms underlying various biological processes. This has opened up new avenues for studying enzyme function and identifying new targets for therapeutic intervention.

The future prospects for (4-Aminobenzoyl)-L-glutamic acid are bright, with ongoing research suggesting numerous possibilities for its application. As our understanding of biological systems continues to grow, so too does the potential for this compound to play a significant role in medicine and biotechnology. Whether it emerges as a lead compound for a new drug or serves as an invaluable tool in scientific research, its contributions are likely to be substantial.

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