Production Method 1

40216-82-8

42538-31-8

Reaction Conditions

1.1 Reagents: Sodium methoxide Solvents: Methanol ;  0 °C; 2 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Methanol ;  rt

Reference

Novel chiral derivatizing agents for 1H NMR determination of enantiomeric purities of carboxylic acids

Wada, Koji; Goto, Mizuko; Yamashita, Hiroshi; Nagasawa, Kazuo, Heterocycles, 2017, 94(5), 964-978

Production Method 2

3184-13-2

42538-31-8

Reaction Conditions

1.1 Reagents: Chlorotrimethylsilane Solvents: Methanol ;  12 h, rt; rt → 0 °C
1.2 Reagents: Sodium ethoxide Solvents: Ethanol ;  5 min, 0 °C; 0 °C → rt; 30 min, rt
1.3 Reagents: Hydrochloric acid Solvents: Water ;  pH 7

Reference

Versatile synthesis of the signaling peptide glorin

Barnett, Robert; Raszkowski, Daniel; Winckler, Thomas; Stallforth, Pierre, Beilstein Journal of Organic Chemistry, 2017, 13, 247-250

Production Method 3

95582-17-5

42538-31-8

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ;  20 h, rt

Reference

Synthesis and biological activity of sulfostin analogs, novel dipeptidyl peptidase IV inhibitors

Abe, Masatoshi; Akiyama, Tetsuo; Umezawa, Yoji; Yamamoto, Keiichiro; Nagai, Masashi; et al, Bioorganic & Medicinal Chemistry, 2005, 13(3), 785-797

Production Method 4

3184-13-2

42538-31-8

Reaction Conditions

1.1 Reagents: Thionyl chloride Solvents: Methanol
1.2 Reagents: Triethylamine Solvents: Acetonitrile

Reference

Three-step synthesis of (R)- and (S)-thalidomides from ornithine

Suzuki, Emiko; Shibata, Norio, Enantiomer, 2001, 6(5), 275-279

(3S)-3-aminopiperidin-2-one;hydrochloride Raw materials

• (S)-3-Cbz-amino-2-piperidone
• H-Orn-OMe Dihydrochloride
• (S)-ornithine hydrochloride

(3S)-3-aminopiperidin-2-one;hydrochloride Preparation Products

• (3S)-3-aminopiperidin-2-one;hydrochloride (42538-31-8)

• 1. Emulsion soft templating of carbide-derived carbon nanospheres with controllable porosity for capacitive electrochemical energy storage?
  M. Zeiger,N. J?ckel,P. Strubel,L. Borchardt,R. Reinhold,W. Nickel,J. Eckert,V. Presser,S. Kaskel J. Mater. Chem. A, 2015,3, 17983-17990
• 2. Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals?
  Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203
• 3. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 4. Fate of single walled carbon nanotubes in wetland ecosystems?
  Joseph H. Bisesi,Tara Sabo-Attwood Environ. Sci.: Nano, 2014,1, 574-583
• 5. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?
  Zhixia Liu,Tingjian Chen,Floyd E. Romesberg Chem. Sci., 2017,8, 8179-8182

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives

Chemical Compound CAS No. 42538-31-8: (3S)-3-Aminopiperidin-2-one; Hydrochloride

The chemical compound with CAS No. 42538-31-8, commonly referred to as (3S)-3-Aminopiperidin-2-one; Hydrochloride, is a significant molecule in the field of organic chemistry and pharmacology. This compound is characterized by its unique structure, which includes a piperidine ring with an amino group at the 3-position and a ketone group at the 2-position. The hydrochloride salt form of this compound is widely studied for its potential applications in drug development and therapeutic interventions.

Recent advancements in chemical synthesis have enabled researchers to explore novel methods for the production of (3S)-3-Aminopiperidin-2-one; Hydrochloride. These methods not only enhance the efficiency of synthesis but also contribute to the scalability of production, making it more accessible for large-scale applications. The stereochemistry of this compound, particularly the (3S) configuration, plays a crucial role in its pharmacokinetic properties and biological activity.

One of the most promising areas of research involving this compound is its application in neuropharmacology. Studies have shown that (3S)-3-Aminopiperidin-2-one; Hydrochloride exhibits potent activity at various neurotransmitter systems, making it a potential candidate for treating neurological disorders such as Parkinson's disease and Alzheimer's disease. The compound's ability to modulate dopamine and serotonin pathways has been extensively investigated, highlighting its potential as a therapeutic agent.

In addition to its pharmacological applications, (3S)-3-Aminopiperidin-2-one; Hydrochloride has also gained attention in the field of chemical biology. Researchers have utilized this compound as a tool to study enzyme inhibition and receptor binding mechanisms. Its structural versatility allows for modifications that can enhance its specificity and efficacy in targeting particular biological systems.

The synthesis of (3S)-3-Aminopiperidin-2-one; Hydrochloride involves a series of well-defined chemical reactions, including nucleophilic substitutions, reductions, and cyclizations. The stereochemical control during these reactions is critical to ensure the formation of the desired (3S) configuration. Advanced techniques such as asymmetric catalysis have been employed to achieve high enantiomeric excess, which is essential for maintaining the compound's biological activity.

From an analytical standpoint, modern spectroscopic techniques such as NMR and mass spectrometry have been instrumental in confirming the structure and purity of (3S)-3-Aminopiperidin-2-one; Hydrochloride. These methods provide detailed insights into the compound's molecular composition and help ensure compliance with quality standards required for pharmaceutical applications.

In conclusion, (3S)-3-Aminopiperidin-2-one; Hydrochloride (CAS No. 42538-31-8) stands out as a versatile and valuable molecule in contemporary chemical research. Its unique properties, coupled with ongoing advancements in synthesis and application methodologies, position it as a key player in the development of novel therapeutic agents and chemical tools for biological studies.

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