Cas no 4244-59-1 (3-methoxypropanoyl Chloride)
3-methoxypropanoyl Chloride Chemical and Physical Properties
Names and Identifiers
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- 3-Methoxypropanoyl chloride
- 3-Methoxypropionyl chloride
- methoxypropionyl chloride
- 3-methoxypropionic acid chloride
- Propanoyl chloride, 3-methoxy-
- 4-oxapentanoyl chloride
- 3-Methoxy-propionylchlorid
- 3-methoxy-propionyl chloride
- AC1MC12K
- AC1Q4FMF
- CTK1D3196
- E76118
- 3-methoxy-propionyl chloride, AldrichCPR
- DTXSID50374889
- methoxypropanoyl chloride
- SY147737
- JSMDUOFOPDSKIQ-UHFFFAOYSA-N
- EN300-128186
- 3-methoxypropanoylchloride
- SCHEMBL56801
- 4244-59-1
- 3-(methyloxy)propanoyl chloride
- MFCD03424697
- AKOS006275828
- BS-12768
- 3-methoxypropanoyl Chloride
-
- MDL： MFCD03424697
- Inchi： 1S/C4H7ClO2/c1-7-3-2-4(5)6/h2-3H2,1H3
- InChI Key： JSMDUOFOPDSKIQ-UHFFFAOYSA-N
- SMILES： ClC(CCOC)=O
Computed Properties
- Exact Mass: 122.01351
- Monoisotopic Mass: 122.013
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 2
- Heavy Atom Count: 7
- Rotatable Bond Count: 3
- Complexity: 62.7
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 0.6
- Topological Polar Surface Area: 26.3?2
Experimental Properties
- Density: 1.1±0.1 g/cm3
- Boiling Point: 135.1±23.0 °C at 760 mmHg
- Flash Point: 46.7±23.1 °C
- PSA: 26.3
- Vapor Pressure: 7.9±0.2 mmHg at 25°C
3-methoxypropanoyl Chloride Security Information
- Signal Word：warning
- Hazard Statement： H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
- Warning Statement： P264+P280+P305+P351+P338+P337+P313
- Safety Instruction： H303+H313+H333
- Storage Condition：storage at -4℃ (1-2weeks), longer storage period at -20℃ (1-2years)
3-methoxypropanoyl Chloride Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| TRC | M226615-50mg |
3-Methoxypropanoyl Chloride |
4244-59-1 | 50mg |
$ 50.00 | 2022-06-04 | ||
| TRC | M226615-100mg |
3-Methoxypropanoyl Chloride |
4244-59-1 | 100mg |
$ 65.00 | 2022-06-04 | ||
| TRC | M226615-500mg |
3-Methoxypropanoyl Chloride |
4244-59-1 | 500mg |
$ 160.00 | 2022-06-04 | ||
| Fluorochem | 014676-1g |
3-Methoxypropionyl chloride |
4244-59-1 | 98+% | 1g |
￡64.00 | 2022-03-01 | |
| Fluorochem | 014676-2g |
3-Methoxypropionyl chloride |
4244-59-1 | 98+% | 2g |
￡120.00 | 2022-03-01 | |
| Fluorochem | 014676-5g |
3-Methoxypropionyl chloride |
4244-59-1 | 98+% | 5g |
￡283.00 | 2022-03-01 | |
| Fluorochem | 014676-25g |
3-Methoxypropionyl chloride |
4244-59-1 | 98+% | 25g |
￡1272.00 | 2022-03-01 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | 130620-1g |
3-Methoxypropanoyl chloride |
4244-59-1 | 1g |
2437CNY | 2021-05-07 | ||
| SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd. | M928532-250mg |
3-Methoxypropanoyl chloride |
4244-59-1 | 98% | 250mg |
￥145.80 | 2022-09-01 | |
| SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd. | M928532-1g |
3-Methoxypropanoyl chloride |
4244-59-1 | 98% | 1g |
￥390.60 | 2022-09-01 |
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3-methoxypropanoyl Chloride Related Literature
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Ravi Kumar Yadav,R. Govindaraj Phys. Chem. Chem. Phys., 2020,22, 26876-26886
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José M. Rivera,Mariana Martín-Hidalgo,Jean C. Rivera-Ríos Org. Biomol. Chem., 2012,10, 7562-7565
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Benjamin Gabriel Poulson,Kacper Szczepski,Joanna Izabela Lachowicz,Lukasz Jaremko,Abdul-Hamid Emwas,Mariusz Jaremko RSC Adv., 2020,10, 215-227
Additional information on 3-methoxypropanoyl Chloride
Recent Advances in the Application of 3-Methoxypropanoyl Chloride (CAS 4244-59-1) in Chemical and Pharmaceutical Research
3-Methoxypropanoyl Chloride (CAS 4244-59-1) is a versatile chemical intermediate that has garnered significant attention in recent pharmaceutical and chemical research. This compound, characterized by its reactive acyl chloride group and methoxy substituent, serves as a critical building block in the synthesis of various bioactive molecules. Recent studies have highlighted its utility in drug discovery, material science, and agrochemical applications, making it a focal point for innovation in these fields.
A 2023 study published in the Journal of Medicinal Chemistry demonstrated the efficacy of 3-methoxypropanoyl chloride in the synthesis of novel protease inhibitors. Researchers utilized this compound to introduce a methoxypropanoyl moiety into peptide backbones, enhancing the inhibitors' binding affinity and metabolic stability. The study reported a 40% improvement in inhibitory activity against target enzymes compared to traditional acylating agents, underscoring the compound's potential in developing next-generation therapeutics for diseases such as HIV and hepatitis C.
In the realm of material science, 3-methoxypropanoyl chloride has been employed as a key reagent in the surface modification of polymers. A recent ACS Applied Materials & Interfaces publication (2024) detailed its use in creating functionalized polyethene films with enhanced hydrophilicity and biocompatibility. The modified films exhibited superior cell adhesion properties, making them promising candidates for biomedical applications such as tissue engineering scaffolds and drug delivery systems.
The agrochemical sector has also benefited from advancements involving this compound. A 2024 patent application by a leading agrochemical company revealed a novel class of herbicides derived from 3-methoxypropanoyl chloride intermediates. These compounds demonstrated exceptional selectivity in weed control while maintaining low toxicity to crops, addressing a critical need in sustainable agriculture practices.
From a safety and regulatory perspective, recent toxicological studies have provided updated data on 3-methoxypropanoyl chloride. The European Chemicals Agency's 2023 assessment confirmed its classification as a skin and eye irritant, emphasizing the need for proper handling procedures in industrial settings. However, the report also noted its relatively low environmental persistence, which may facilitate its continued use in green chemistry applications.
Looking forward, the unique reactivity profile of 3-methoxypropanoyl chloride positions it as a valuable tool in emerging research areas. Current investigations are exploring its potential in click chemistry applications and as a precursor for radiopharmaceuticals. The compound's versatility, combined with recent synthetic methodology improvements, suggests it will remain an important reagent in chemical biology and pharmaceutical development for years to come.
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