Cas no 41927-17-7 (4-(Benzyloxy)benzene-1,2-diamine)

4-(Benzyloxy)benzene-1,2-diamine is a benzyl-protected diamine derivative primarily used as an intermediate in organic synthesis and pharmaceutical research. Its key advantages include its role as a precursor in the preparation of heterocyclic compounds, such as benzimidazoles and quinoxalines, due to the reactivity of its ortho-diamine functional group. The benzyloxy group provides stability and selective deprotection options, enhancing its utility in multi-step synthetic routes. This compound is particularly valuable in medicinal chemistry for developing biologically active molecules. High purity grades ensure consistent performance in sensitive reactions, making it a reliable choice for research and industrial applications.
4-(Benzyloxy)benzene-1,2-diamine structure
41927-17-7 structure
Product Name:4-(Benzyloxy)benzene-1,2-diamine
CAS No:41927-17-7
MF:C13H14N2O
MW:214.263062953949
MDL:MFCD09753449
CID:1090328
PubChem ID:13162239
Update Time:2025-11-02

4-(Benzyloxy)benzene-1,2-diamine Chemical and Physical Properties

Names and Identifiers

    • 4-(Benzyloxy)benzene-1,2-diamine
    • 4-phenylmethoxybenzene-1,2-diamine
    • 4-benzyloxy-1,2-phenylenediamine
    • 4-BENZYLOXY-1,2-PHENYLENEDIAMINE DIHYDROCHLORIDE
    • 4-benzyloxybenzene-1,2-diamine
    • 4-Benzyloxy-o-phenylendiamin
    • AS-77287
    • SCHEMBL4473165
    • 41927-17-7
    • 1,2-diamino-4-benzyloxybenzene
    • MFCD09753449
    • D94829
    • UQVGKXPXBIVFMV-UHFFFAOYSA-N
    • A1-36175
    • A855541
    • DTXSID60523649
    • SB79491
    • DA-22320
    • CS-0156186
    • 2-amino-4-(benzyloxy)aniline
    • MDL： MFCD09753449
    • Inchi： 1S/C13H14N2O/c14-12-7-6-11(8-13(12)15)16-9-10-4-2-1-3-5-10/h1-8H,9,14-15H2
    • InChI Key： UQVGKXPXBIVFMV-UHFFFAOYSA-N
    • SMILES： O(C1=CC=C(C(=C1)N)N)CC1C=CC=CC=1

Computed Properties

  • Exact Mass: 214.11100
  • Monoisotopic Mass: 214.110613074g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 16
  • Rotatable Bond Count: 3
  • Complexity: 204
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 2
  • Topological Polar Surface Area: 61.3?2

Experimental Properties

  • PSA: 61.27000
  • LogP: 3.59240

4-(Benzyloxy)benzene-1,2-diamine Customs Data

  • HS CODE：2922299090
  • Customs Data：

    China Customs Code:

    2922299090

    Overview:

    2922299090. Other amino groups(naphthol\phenol)And ether\Esters [including their salts, Except those containing more than one oxygen-containing group]. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to, The color of ethanolamine and its salt should be reported, The package of ethanolamine and its salt shall be declared

    Summary:

    2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

4-(Benzyloxy)benzene-1,2-diamine Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd.
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4-(Benzyloxy)benzene-1,2-diamine
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SHANG HAI XIAN DING Biotechnology Co., Ltd.
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SHANG HAI XIAN DING Biotechnology Co., Ltd.
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abcr
AB565004-250 mg
4-(Benzyloxy)benzene-1,2-diamine; .
 41927-17-7
250MG
 €350.10 2023-04-13

4-(Benzyloxy)benzene-1,2-diamine Related Literature

Additional information on 4-(Benzyloxy)benzene-1,2-diamine

Recent Advances in the Application of 4-(Benzyloxy)benzene-1,2-diamine (CAS: 41927-17-7) in Chemical Biology and Pharmaceutical Research

The compound 4-(Benzyloxy)benzene-1,2-diamine (CAS: 41927-17-7) has recently garnered significant attention in the field of chemical biology and pharmaceutical research due to its versatile applications in drug discovery and development. This research briefing aims to provide an overview of the latest advancements related to this compound, focusing on its synthesis, biological activities, and potential therapeutic applications. The findings discussed herein are derived from recent peer-reviewed publications and industry reports, ensuring the accuracy and relevance of the information presented.

Recent studies have highlighted the role of 4-(Benzyloxy)benzene-1,2-diamine as a key intermediate in the synthesis of heterocyclic compounds, particularly benzimidazole derivatives. These derivatives exhibit a wide range of pharmacological activities, including antimicrobial, anticancer, and anti-inflammatory properties. For instance, a 2023 study published in the Journal of Medicinal Chemistry demonstrated the efficacy of benzimidazole-based compounds derived from 4-(Benzyloxy)benzene-1,2-diamine in inhibiting the growth of multidrug-resistant bacterial strains. The study employed a combination of in vitro and in silico approaches to elucidate the mechanism of action, revealing strong binding affinities to bacterial DNA gyrase.

In addition to its antimicrobial potential, 4-(Benzyloxy)benzene-1,2-diamine has been investigated for its role in cancer therapy. A recent preclinical study reported in Bioorganic & Medicinal Chemistry Letters explored the compound's ability to serve as a scaffold for the development of small-molecule inhibitors targeting tyrosine kinases. The researchers synthesized a series of analogs and evaluated their cytotoxic effects on various cancer cell lines, with several analogs showing promising activity against breast and lung cancer cells. These findings underscore the compound's potential as a lead structure for anticancer drug development.

Another area of interest is the application of 4-(Benzyloxy)benzene-1,2-diamine in the design of fluorescent probes for biological imaging. A 2022 study in Analytical Chemistry described the synthesis of a novel fluorescent probe based on this compound, which exhibited high selectivity for detecting reactive oxygen species (ROS) in live cells. The probe's ability to provide real-time monitoring of ROS levels has significant implications for studying oxidative stress-related diseases, such as neurodegenerative disorders and cardiovascular diseases.

Despite these promising developments, challenges remain in optimizing the pharmacokinetic and safety profiles of derivatives derived from 4-(Benzyloxy)benzene-1,2-diamine. Future research directions may include structure-activity relationship (SAR) studies to enhance selectivity and reduce off-target effects, as well as the exploration of novel delivery systems to improve bioavailability. In conclusion, the compound 4-(Benzyloxy)benzene-1,2-diamine (CAS: 41927-17-7) continues to be a valuable tool in chemical biology and pharmaceutical research, with its diverse applications paving the way for innovative therapeutic strategies.

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