• 1. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126
• 2. Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals?
  Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203
• 3. Exceptionally high temperature spin crossover in amide-functionalised 2,6-bis(pyrazol-1-yl)pyridine iron(ii) complex revealed by variable temperature Raman spectroscopy and single crystal X-ray diffraction?
  Max Attwood,Hiroki Akutsu,Lee Martin,Toby J. Blundell,Pierre Le Maguere,Scott S. Turner Dalton Trans., 2021,50, 11843-11851
• 4. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
  Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526
• 5. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Halopyrimidines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyrimidines and pyrimidine derivatives Halopyrimidines

Introduction to N'4'-Butyl-6-chloro-pyrimidine-4,5-diamine (CAS No. 41259-67-0)

N'4'-Butyl-6-chloro-pyrimidine-4,5-diamine, with the chemical formula C₉H₁₄ClN₃, is a significant compound in the field of pharmaceutical and agrochemical research. This heterocyclic amine has garnered considerable attention due to its versatile applications and structural properties. The compound's molecular structure, featuring a pyrimidine core with substituents at the 4' and 6' positions, makes it a valuable intermediate in the synthesis of various biologically active molecules.

The CAS number 41259-67-0 uniquely identifies this chemical entity, ensuring precise documentation and classification within scientific databases. As a chlorinated pyrimidine derivative, N'4'-Butyl-6-chloro-pyrimidine-4,5-diamine exhibits distinct reactivity patterns that are exploited in synthetic chemistry. Its dual amine functionalities at the 4 and 5 positions provide multiple sites for further functionalization, making it a crucial building block in medicinal chemistry.

In recent years, the pharmaceutical industry has shown increasing interest in pyrimidine-based scaffolds due to their prevalence in many therapeutic agents. N'4'-Butyl-6-chloro-pyrimidine-4,5-diamine serves as a key precursor in the development of novel drugs targeting various diseases. For instance, its structural motif is closely related to compounds that have demonstrated efficacy in oncology and antiviral therapies. The chloro substituent at the 6-position enhances its utility as a reactive handle, facilitating nucleophilic substitution reactions that are pivotal in drug design.

One of the most compelling aspects of N'4'-Butyl-6-chloro-pyrimidine-4,5-diamine is its role in the synthesis of kinase inhibitors, which are critical in cancer treatment. The pyrimidine ring mimics ATP binding sites, allowing these inhibitors to disrupt signaling pathways involved in cell proliferation. Recent studies have highlighted its potential in developing next-generation tyrosine kinase inhibitors (TKIs), which exhibit improved selectivity and reduced side effects compared to earlier generations. The butyl group at the 4-position contributes to the compound's solubility and pharmacokinetic properties, enhancing its suitability for oral administration.

The agrochemical sector also benefits from this compound's versatility. Pyrimidine derivatives are widely used as intermediates in the production of herbicides and fungicides. N'4'-Butyl-6-chloro-pyrimidine-4,5-diamine has been investigated for its ability to inhibit enzymes essential for plant pathogen growth, offering a promising candidate for developing sustainable agricultural solutions. Its stability under various environmental conditions makes it an attractive option for field applications.

From a synthetic chemistry perspective, N'4'-Butyl-6-chloro-pyrimidine-4,5-diamine is notable for its ease of modification. Researchers can introduce additional functional groups or alter existing ones to tailor the compound's biological activity. This flexibility is particularly valuable in high-throughput screening programs aimed at identifying lead compounds for drug development. The diamine structure allows for diversification into libraries of analogs with distinct pharmacological profiles.

The compound's electronic properties make it an interesting candidate for material science applications as well. Pyrimidine-based molecules are known for their ability to absorb light across multiple wavelengths, making them useful in organic electronics and photovoltaic devices. While this application is still emerging, preliminary research suggests that derivatives of N'4'-Butyl-6-chloro-pyrimidine-4,5-diamine could contribute to advancements in energy-efficient technologies.

In conclusion, N'4'-Butyl-6-chloro-pyrimidine-4,5-diamine (CAS No. 41259-67-0) is a multifaceted compound with significant implications across pharmaceuticals and agrochemicals. Its unique structural features enable diverse applications in drug discovery and material science. As research continues to uncover new synthetic pathways and biological functions, this compound is poised to remain a cornerstone of innovation in the chemical sciences.

• 84762-70-9(4-Chloro-6-piperidin-1-yl-pyrimidin-5-ylamine)
• 6270-25-3(2,4,5-Pyrimidinetriamine,N4-butyl-6-chloro-)
• 5452-43-7(6-Chloro-N'4'-cyclopentyl-pyrimidine-4,5-diamine)
• 195252-62-1(6-chloro-N4-cyclopropylpyrimidine-4,5-diamine)
• 114153-80-9(5-[(5-amino-6-chloropyrimidin-4-yl)amino]pentan-1-ol)
• 181304-94-9(6-chloro-4-N-(prop-2-en-1-yl)pyrimidine-4,5-diamine)
• 195252-56-3(6-chloro-4-N-propylpyrimidine-4,5-diamine)
• 5449-10-5(6-Chloro-N4-cyclohexyl-pyrimidine-4,5-diamine)
• 98140-03-5(6-chloro-N4-ethylpyrimidine-4,5-diamine)
• 626217-76-3(4-Chloro-6-(pyrrolidin-1-yl)pyrimidin-5-amine)