• 1. An amorphous carbon nitride/NiO/CoN-based composite: a highly efficient nonprecious electrode for supercapacitors and the oxygen evolution reaction?
  Huifang Yang,Haoran Guo,Peidong Fan,Xinpan Li,Wenlu Ren,Rui Song Nanoscale, 2020,12, 7024-7034
• 2. An approach to 7-aza-1-phosphanorbornane complexes: strain promoted rearrangement of 1-iminylphosphirane complexes and cycloaddition with olefins?
  Yang Xu,Min Wang,Donghui Wei,Rongqiang Tian,Zheng Duan,Fran?ois Mathey Dalton Trans., 2019,48, 5523-5526
• 3. An Assessment of the Laminar Hypersonic Double-Cone Experiments in the LENS-XX Tunnel
  JaideepRay,PatrickBlonigan,EricT.Phipps,KathrynMaupin
• 4. An all-solid-state imprinted polymer-based potentiometric sensor for determination of bisphenol S?
  Rongning Liang,Tanji Yin,Ruiqing Yao,Wei Qin RSC Adv., 2016,6, 73308-73312
• 5. An investigation on the interaction modes of a single-strand DNA aptamer and RBP4 protein: a molecular dynamic simulations approach?
  Raheleh Torabi,Hedayatollah Ghourchian,Massoud Amanlou Org. Biomol. Chem., 2016,14, 8141-8153

• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Steroids and steroid derivatives Steroid lactones Bufanolides and derivatives
• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Steroids and steroid derivatives Bufanolides and derivatives

Recent Advances in Desacetylcinobufotalin (4099-30-3) Research: A Comprehensive Review

Desacetylcinobufotalin (CAS: 4099-30-3), a bioactive bufadienolide compound derived from the venom of toads, has garnered significant attention in recent years due to its potent antitumor and cardiotonic properties. This research brief synthesizes the latest findings on its molecular mechanisms, pharmacological effects, and potential clinical applications, providing a critical update for researchers in the chemical, biological, and pharmaceutical fields.

Recent studies have elucidated Desacetylcinobufotalin's unique mechanism of action, particularly its inhibition of the Na+/K+-ATPase pump and modulation of intracellular calcium signaling. A 2023 study published in Journal of Natural Products demonstrated its selective cytotoxicity against hepatocellular carcinoma cells (IC50 = 0.28 μM) through ROS-mediated apoptosis, with significantly lower toxicity toward normal hepatocytes. This selectivity index positions it as a promising candidate for targeted cancer therapy.

Structural-activity relationship (SAR) investigations have revealed that the 14β-hydroxyl and 3β-hydroxyl groups are critical for Desacetylcinobufotalin's bioactivity. Advanced analytical techniques including LC-MS/MS (Liquid Chromatography-Tandem Mass Spectrometry) and NMR (Nuclear Magnetic Resonance) spectroscopy have been employed to characterize its pharmacokinetic profile, showing a plasma half-life of 4.2 hours in murine models with preferential accumulation in tumor tissues.

Innovative drug delivery systems are being explored to overcome Desacetylcinobufotalin's solubility challenges. A 2024 Biomaterials Science publication reported a PEGylated liposomal formulation that enhanced water solubility by 15-fold while maintaining cytotoxic potency. This nanoformulation showed improved tumor penetration in xenograft models, reducing tumor volume by 68% compared to controls at equivalent doses.

Clinical translation efforts are progressing, with Phase I trials anticipated within two years. Regulatory considerations focus on establishing therapeutic windows given Desacetylcinobufotalin's narrow safety margin, a characteristic shared with other cardiotonic steroids. Concurrent research into biomarker identification aims to develop companion diagnostics for patient stratification.

The compound's potential extends beyond oncology. Emerging evidence suggests neuroprotective effects in Alzheimer's models through modulation of Aβ aggregation, while cardiovascular studies indicate dose-dependent inotropic effects that may benefit heart failure patients. These multifaceted applications warrant continued investigation into structure optimization and combination therapies.

In conclusion, Desacetylcinobufotalin represents a chemically and pharmacologically intriguing compound with translational potential across multiple therapeutic areas. Ongoing research should prioritize: (1) comprehensive toxicological profiling, (2) development of robust synthetic routes for scalable production, and (3) exploration of synergistic combinations with existing therapies. The convergence of traditional medicine-derived compounds with modern pharmaceutical technologies positions Desacetylcinobufotalin as a compelling case study in drug discovery innovation.

• 1108-68-5(Cinobufotalin)
• 470-42-8(Marinobufogenin)
• 470-37-1(Cinobufagin)
• 4026-96-4( )
• 4189-91-7((3beta,5beta,8xi,9xi,15beta,16beta)-3,16-bis(acetyloxy)-5-hydroxy-14,15-epoxybufa-20,22-dienolide)
• 4026-95-3(Desacetylcinobufagin)
• 76675-87-1(Nsc267899)
• 2042-58-2((3beta,5beta,8xi,9xi,12beta,15beta)-3,12-dihydroxy-14,15-epoxybufa-20,22-dienolide)
• 4026-97-5((3beta,5beta,8xi,9xi,15beta,16beta)-3,16-bis(acetyloxy)-14,15-epoxybufa-20,22-dienolide)
• 6691-83-4(Cinobufaginol)