Production Method 1

614-19-7

40856-44-8

83649-48-3

Reaction Conditions

1.1 Reagents: Thionyl chloride Solvents: Ethanol
1.2 Reagents: Potassium carbonate Solvents: Water
2.1 Reagents: Water Solvents: Isopropanol ;  22 h, 45 °C
2.2 Reagents: Hydrochloric acid Solvents: Water

Reference

Enzymic synthesis of β-aryl and β-heteroaryl-substituted β-amino acid enantiomers

Tasnadi, Gabor; et al, Magyar Kemiai Folyoirat, 2010, 116(3), 131-136

Production Method 2

6335-76-8

40856-44-8

83649-48-3

Reaction Conditions

1.1 Reagents: Water Solvents: Isopropanol ;  22 h, 45 °C
1.2 Reagents: Hydrochloric acid Solvents: Water

Reference

Enzymic synthesis of β-aryl and β-heteroaryl-substituted β-amino acid enantiomers

Tasnadi, Gabor; et al, Magyar Kemiai Folyoirat, 2010, 116(3), 131-136

Production Method 3

141-82-2

100-52-7

40856-44-8

83649-48-3

Reaction Conditions

1.1 Reagents: Ammonium acetate Solvents: Ethanol ;  reflux
2.1 Reagents: Thionyl chloride Solvents: Ethanol
2.2 Reagents: Potassium carbonate Solvents: Water
3.1 Reagents: Water Solvents: Isopropanol ;  22 h, 45 °C
3.2 Reagents: Hydrochloric acid Solvents: Water

Reference

Enzymic synthesis of β-aryl and β-heteroaryl-substituted β-amino acid enantiomers

Tasnadi, Gabor; et al, Magyar Kemiai Folyoirat, 2010, 116(3), 131-136

(3S)-3-amino-3-phenylpropanoic acid Raw materials

• propanedioic acid
• Ethyl 3-amino-3-phenylpropanoate
• DL-β-Phenylalanine
• Benzaldehyde

(3S)-3-amino-3-phenylpropanoic acid Preparation Products

• (3S)-3-amino-3-phenylpropanoic acid (40856-44-8)
• (R)-3-Amino-3-phenylpropanoic acid hydrochloride (83649-48-3)

• 1. Design and preparation of serine–threonine protein phosphatase inhibitors based upon the nodularin and microcystin toxin structures. Part 3
  Kerri L. Webster,Antony B. Maude,Michael E. O'Donnell,Amit P. Mehrotra,David Gani J. Chem. Soc. Perkin Trans. 1 2001 1673
• 2. One step access to oxindole-based β-lactams through Ugi four-center three-component reaction
  Giulia Rainoldi,Giordano Lesma,Claudia Picozzi,Leonardo Lo Presti,Alessandra Silvani RSC Adv. 2018 8 34903
• 3. Kinetic resolution of aromatic β-amino acids by ω-transaminase
  Han-Seop Bea,Hye-Jeong Park,Sang-Hyeup Lee,Hyungdon Yun Chem. Commun. 2011 47 5894
• 4. Asymmetric dual catalysis via fragmentation of a single rhodium precursor complex
  Liangliang Song,Lei Gong,Eric Meggers Chem. Commun. 2016 52 7699
• 5. Diastereoselective Ireland–Claisen rearrangements of substituted allyl β-amino esters: applications in the asymmetric synthesis of C(5)-substituted transpentacins
  Stephen G. Davies,Ai M. Fletcher,James A. Lee,Paul M. Roberts,Myriam Y. Souleymanou,James E. Thomson,Charlotte M. Zammit Org. Biomol. Chem. 2014 12 2702

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

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