Cas no 408352-90-9 (1-(2-Phenyl-1,3-oxazol-4-yl)methanamine)

1-(2-Phenyl-1,3-oxazol-4-yl)methanamine is a versatile heterocyclic amine featuring a phenyl-substituted oxazole core. This compound is valued for its structural rigidity and electron-rich aromatic system, making it a useful intermediate in organic synthesis and medicinal chemistry. The oxazole ring enhances stability while the primary amine group provides a reactive site for further functionalization, such as amide bond formation or Schiff base synthesis. Its well-defined molecular architecture is advantageous in the design of pharmacophores, particularly for targeting CNS and antimicrobial applications. The compound’s purity and consistent reactivity make it suitable for high-precision research and industrial applications requiring tailored heterocyclic scaffolds.
1-(2-Phenyl-1,3-oxazol-4-yl)methanamine structure
408352-90-9 structure
Product Name:1-(2-Phenyl-1,3-oxazol-4-yl)methanamine
CAS No:408352-90-9
MF:C10H10N2O
MW:174.199202060699
MDL:MFCD06738563
CID:326212
PubChem ID:26249073
Update Time:2025-06-08

1-(2-Phenyl-1,3-oxazol-4-yl)methanamine Chemical and Physical Properties

Names and Identifiers

    • (2-Phenyloxazol-4-yl)methanamine
    • (2-phenyl-1,3-oxazol-4-yl)methanamine
    • 2-phenyl-4-Oxazolemethanamine
    • 4-OXAZOLEMETHANAMINE, 2-PHENYL-
    • (2-phenyl-4-oxazolyl)methanamine
    • 1-(2-phenyl-1,3-oxazol-4-yl)methanamine(SALTDATA: HCl)
    • 4-Oxazolemethanamine,2-phenyl
    • C-(2-Phenyl-Oxazol-4-Yl)-Methylamine
    • (2-PHENYL-OXAZOL-4-YL)METHYLAMINE
    • DTXSID80649890
    • AKOS006242765
    • CS-0106513
    • SCHEMBL3126496
    • EN300-91870
    • (2-phenyl-1,3-oxazol-4-yl)methanamine, AldrichCPR
    • A825307
    • 4-AMINOMETHYL-2-PHENYL-OXAZOLE
    • 1-(2-PHENYL-1,3-OXAZOL-4-YL)METHANAMINE
    • FT-0692565
    • 408352-90-9
    • AB27391
    • 1-(2-Phenyl-1,3-oxazol-4-yl)methanamine
    • MDL: MFCD06738563
    • Inchi: 1S/C10H10N2O/c11-6-9-7-13-10(12-9)8-4-2-1-3-5-8/h1-5,7H,6,11H2
    • InChI Key: NGYFPQIRGGHIHK-UHFFFAOYSA-N
    • SMILES: O1C=C(CN)N=C1C1C=CC=CC=1

Computed Properties

  • Exact Mass: 174.07900
  • Monoisotopic Mass: 174.079
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 13
  • Rotatable Bond Count: 2
  • Complexity: 157
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 52A^2
  • XLogP3: 0.9

Experimental Properties

  • Density: 1.155
  • Boiling Point: 326.7°C at 760 mmHg
  • Flash Point: 151.4°C
  • Refractive Index: 1.573
  • PSA: 52.05000
  • LogP: 2.50060
  • Vapor Pressure: 0.0±0.7 mmHg at 25°C

1-(2-Phenyl-1,3-oxazol-4-yl)methanamine Security Information

1-(2-Phenyl-1,3-oxazol-4-yl)methanamine Customs Data

  • HS CODE:2934999090
  • Customs Data:

    China Customs Code:

    2934999090

    Overview:

    2934999090. Other heterocyclic compounds. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Additional information on 1-(2-Phenyl-1,3-oxazol-4-yl)methanamine

Introduction to 1-(2-Phenyl-1,3-oxazol-4-yl)methanamine (CAS No. 408352-90-9)

1-(2-Phenyl-1,3-oxazol-4-yl)methanamine, identified by its Chemical Abstracts Service (CAS) number 408352-90-9, is a specialized organic compound that has garnered significant attention in the field of pharmaceutical chemistry and medicinal research. This compound belongs to the oxazole derivatives class, which is well-documented for its diverse biological activities and potential therapeutic applications. The structural framework of 1-(2-Phenyl-1,3-oxazol-4-yl)methanamine incorporates a phenyl ring and an oxazole moiety, both of which are known to contribute to its unique chemical properties and biological interactions.

The oxazole ring, a five-membered heterocyclic structure containing one oxygen and one nitrogen atom, is a key pharmacophore in many bioactive molecules. Its presence in 1-(2-Phenyl-1,3-oxazol-4-yl)methanamine not only enhances the compound's solubility and stability but also facilitates its interaction with biological targets. The phenyl group, on the other hand, provides additional hydrophobicity and can influence the compound's binding affinity to proteins and enzymes. This combination of structural features makes 1-(2-Phenyl-1,3-oxazol-4-yl)methanamine a promising candidate for further investigation in drug discovery.

In recent years, there has been a surge in research focused on developing novel therapeutic agents with improved efficacy and reduced side effects. 1-(2-Phenyl-1,3-oxazol-4-yl)methanamine has emerged as a compound of interest in this context due to its potential role in modulating various biological pathways. Studies have suggested that this molecule may exhibit inhibitory effects on certain enzymes and receptors involved in inflammation, cancer, and neurodegenerative diseases. The oxazole moiety, in particular, has been shown to interact with biological targets in ways that could lead to therapeutic benefits.

One of the most compelling aspects of 1-(2-Phenyl-1,3-oxazol-4-yl)methanamine is its versatility in chemical modifications. Researchers can easily append or substitute functional groups on the phenyl ring or the oxazole ring to tailor its biological activity. This flexibility allows for the design of derivatives with enhanced potency, selectivity, and pharmacokinetic properties. For instance, modifications such as halogenation or alkylation can significantly alter the compound's interaction with biological targets, making it a valuable scaffold for structure-based drug design.

The synthesis of 1-(2-Phenyl-1,3-oxazol-4-yl)methanamine involves multi-step organic reactions that require precise control over reaction conditions and reagent selection. Advanced synthetic methodologies have been employed to optimize yield and purity, ensuring that the final product meets the stringent requirements for pharmaceutical applications. Techniques such as palladium-catalyzed cross-coupling reactions and nucleophilic substitution have been particularly useful in constructing the complex framework of this compound.

From a medicinal chemistry perspective, 1-(2-Phenyl-1,3-ozaXole)-4-ylmethanamine (CAS No. 408352909) represents an exciting opportunity for further exploration. Its unique structural features and potential biological activities make it a compelling candidate for preclinical and clinical studies. Researchers are currently investigating its effects on various disease models to determine its therapeutic potential. Preliminary findings suggest that this compound may have applications in treating conditions such as chronic inflammation and neurodegenerative disorders.

The growing interest in (Z)-N-(2-Hydroxyphenyl)-N'-[(E)-(4-hydroxyphenylethynylidene)]dithiocarbamide underscores the importance of innovative approaches in drug discovery. By leveraging computational modeling and high-throughput screening techniques, scientists can accelerate the process of identifying promising candidates like (Z)-N-(2-Hydroxyphenyl)-N'-[(E)-(4-hydroxyphenylethynylidene)]dithiocarbamide for further development. These advancements not only enhance efficiency but also reduce costs associated with traditional drug development pipelines.

In conclusion,(Z)-N-(2-HydroxyphenyI)-N'-[(E)-(4-hydroxyphenylethynylidene)]dithiocarbamide, CAS No. 408352909, stands out as a significant compound in pharmaceutical research due to its structural complexity, bioactivity,and synthetic versatility. Its potential applications in treating various diseases make it a valuable asset for researchers striving to develop novel therapeutic agents. As scientific understanding continues to evolve,(Z)-N-(2-HydroxyphenyI)-N'-[(E)-(4-hydroxyphenylethynylidene)]dithiocarbamide is expected to play an increasingly important role in advancing medical science.

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