Cas no 4053-36-5 (8-Methylquinolin-2(1H)-one)

8-Methylquinolin-2(1H)-one is a heterocyclic organic compound featuring a quinoline backbone with a methyl substituent at the 8-position and a ketone group at the 2-position. This structure imparts unique reactivity, making it a valuable intermediate in pharmaceutical and agrochemical synthesis. Its rigid fused-ring system enhances stability, while the functional groups allow for selective modifications, enabling applications in ligand design and medicinal chemistry. The compound exhibits favorable solubility in common organic solvents, facilitating its use in diverse reaction conditions. Its well-defined molecular framework also supports research in fluorescence studies and coordination chemistry. High purity grades are available for precision-driven applications.
8-Methylquinolin-2(1H)-one structure
8-Methylquinolin-2(1H)-one structure
Product Name:8-Methylquinolin-2(1H)-one
CAS No:4053-36-5
MF:C10H9NO
MW:159.184562444687
MDL:MFCD13195790
CID:857572
PubChem ID:5325167
Update Time:2025-11-02

8-Methylquinolin-2(1H)-one Chemical and Physical Properties

Names and Identifiers

    • 8-Methylquinolin-2(1H)-one
    • 8-Methyl-2(1H)-quinolinone
    • 2-Hydroxy-8-methylquinoline
    • 8-methyl-1H-quinolin-2-one
    • 2(1H)-Quinolinone, 8-methyl-
    • 8-methyl-2-quinolone
    • 8-Methylcarbostyril
    • 2-Hydroxy-8-methyl-chinolin
    • XXPVCQMOIBCSDT-UHFFFAOYSA-N
    • 8-methyl-1,2-dihydroquinolin-2-one
    • SY021046
    • V5800
    • Q27121424
    • EN300-625027
    • CS-0187288
    • DTXSID60415994
    • AS-32441
    • InChI=1/C10H9NO/c1-7-3-2-4-8-5-6-9(12)11-10(7)8/h2-6H,1H3,(H,11,12
    • DB-360037
    • CHEBI:48989
    • SB67880
    • 4053-36-5
    • MFCD13195790
    • AKOS013465675
    • SCHEMBL433883
    • 8-METHYLQUINOLIN-2-OL
    • MDL: MFCD13195790
    • Inchi: 1S/C10H9NO/c1-7-3-2-4-8-5-6-9(12)11-10(7)8/h2-6H,1H3,(H,11,12)
    • InChI Key: XXPVCQMOIBCSDT-UHFFFAOYSA-N
    • SMILES: O=C1C=CC2C=CC=C(C)C=2N1

Computed Properties

  • Exact Mass: 159.06800
  • Monoisotopic Mass: 159.068413911g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 1
  • Heavy Atom Count: 12
  • Rotatable Bond Count: 0
  • Complexity: 222
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 29.1
  • XLogP3: 1.7

Experimental Properties

  • Boiling Point: 339.3±42.0℃ at 760mmHg
  • PSA: 33.12000
  • LogP: 2.24880

8-Methylquinolin-2(1H)-one Customs Data

  • HS CODE:2933499090
  • Customs Data:

    China Customs Code:

    2933499090

    Overview:

    2933499090. Other compounds containing quinoline or isoquinoline ring system [but not further fused]. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

8-Methylquinolin-2(1H)-one Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
Alichem
A189006843-5g
8-Methylquinolin-2(1H)-one
4053-36-5 95%
5g
$374.40 2023-09-02
Alichem
A189006843-10g
8-Methylquinolin-2(1H)-one
4053-36-5 95%
10g
$743.60 2023-09-02
Alichem
A189006843-25g
8-Methylquinolin-2(1H)-one
4053-36-5 95%
25g
$1040.40 2023-09-02
SHANG HAI XIAN DING Biotechnology Co., Ltd.
B-MD586-1g
8-Methylquinolin-2(1H)-one
4053-36-5 97%
1g
261.0CNY 2021-08-05
SHANG HAI XIAN DING Biotechnology Co., Ltd.
B-MD586-5g
8-Methylquinolin-2(1H)-one
4053-36-5 97%
5g
1049.0CNY 2021-08-05
SHANG HAI XIAN DING Biotechnology Co., Ltd.
B-MD586-200mg
8-Methylquinolin-2(1H)-one
4053-36-5 97%
200mg
96.0CNY 2021-08-05
Chemenu
CM144948-5g
8-Methylquinolin-2(1H)-one
4053-36-5 95%
5g
$337 2021-08-05
Chemenu
CM144948-10g
8-Methylquinolin-2(1H)-one
4053-36-5 95%
10g
$669 2021-08-05
SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd.
D852289-250mg
8-Methyl-2(1H)-quinolinone
4053-36-5 ≥95%
250mg
348.30 2021-05-17
Fluorochem
216065-1g
8-Methylquinolin-2(1H)-one
4053-36-5 95%
1g
£117.00 2022-03-01

8-Methylquinolin-2(1H)-one Production Method

8-Methylquinolin-2(1H)-one Related Literature

Additional information on 8-Methylquinolin-2(1H)-one

Exploring the Versatile Applications and Properties of 8-Methylquinolin-2(1H)-one (CAS No. 4053-36-5)

8-Methylquinolin-2(1H)-one (CAS No. 4053-36-5) is a fascinating heterocyclic compound that has garnered significant attention in the fields of organic chemistry, pharmaceuticals, and material science. This compound, also known as 8-methyl-2-quinolone, belongs to the quinoline family, which is renowned for its diverse biological activities and industrial applications. The unique structural features of 8-Methylquinolin-2(1H)-one make it a valuable intermediate in the synthesis of more complex molecules, particularly in drug discovery and development.

One of the most intriguing aspects of 8-Methylquinolin-2(1H)-one is its molecular structure, which combines a quinoline backbone with a methyl group at the 8-position and a ketone functionality at the 2-position. This arrangement imparts distinct chemical properties, such as enhanced stability and reactivity, which are highly sought after in synthetic chemistry. Researchers have explored its potential as a building block for pharmaceutical intermediates, owing to its ability to participate in various coupling reactions and functional group transformations.

In recent years, the demand for 8-Methylquinolin-2(1H)-one has surged due to its role in the development of novel therapeutic agents. For instance, quinoline derivatives are frequently investigated for their antimicrobial, anticancer, and anti-inflammatory properties. The 8-methyl-2-quinolone scaffold, in particular, has shown promise in modulating biological pathways, making it a focal point for medicinal chemists. This aligns with the growing trend of targeting heterocyclic compounds for drug design, as highlighted by numerous publications and patents.

Beyond pharmaceuticals, 8-Methylquinolin-2(1H)-one finds applications in material science, where its photophysical properties are exploited for developing organic light-emitting diodes (OLEDs) and fluorescent probes. The compound’s ability to absorb and emit light at specific wavelengths makes it a candidate for advanced materials used in sensors and optoelectronic devices. This versatility has sparked interest among researchers working on sustainable and high-performance materials, a topic that resonates with current environmental and technological trends.

The synthesis of 8-Methylquinolin-2(1H)-one typically involves multi-step organic reactions, starting from readily available precursors like aniline derivatives. Modern synthetic routes emphasize efficiency and green chemistry principles, such as catalytic methods and solvent-free conditions, to minimize environmental impact. These advancements address the increasing consumer and regulatory focus on sustainable chemistry, a hot topic in both academic and industrial circles.

From a commercial perspective, 8-Methylquinolin-2(1H)-one is supplied by specialized chemical manufacturers and distributors catering to research institutions and pharmaceutical companies. Its market dynamics are influenced by factors like R&D investments, patent expirations, and the emergence of new applications. For buyers, key considerations include purity, scalability, and compliance with regulatory standards, which are frequently searched topics in procurement databases.

In summary, 8-Methylquinolin-2(1H)-one (CAS No. 4053-36-5) is a multifaceted compound with significant potential across multiple industries. Its structural elegance, combined with its applicability in drug discovery and material science, ensures its continued relevance in scientific research. As the demand for innovative and sustainable chemical solutions grows, compounds like 8-methyl-2-quinolone will undoubtedly remain at the forefront of scientific and industrial advancements.

Recommended suppliers
Yunnanjiuzhen
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Bulk
Yunnanjiuzhen
Handan Zechi Trading Co., Ltd
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Bulk
Hangzhou TSurgeX Pharmaceutical Technology Co., Ltd.
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Reagent
Hangzhou TSurgeX Pharmaceutical Technology Co., Ltd.
Zhejiang Brunova Technology Co., Ltd.
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Bulk
Zhejiang Brunova Technology Co., Ltd.
煙臺(tái)朗裕新材料科技有限公司
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Reagent