• 1. Residue-based program of a β-peptoid twisted strand shape via a cyclopentane constraint
  Jungyeon Kim,Hiroka Kobayashi,Marin Yokomine,Yota Shiratori,Takumi Ueda,Koh Takeuchi,Koji Umezawa,Daisuke Kuroda,Kouhei Tsumoto,Jumpei Morimoto,Shinsuke Sando Org. Biomol. Chem. 2022 20 6994

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives

Comprehensive Overview of trans-2-aminocyclopentanecarboxylic acid (CAS No. 40482-05-1)

trans-2-aminocyclopentanecarboxylic acid (CAS No. 40482-05-1) is a cyclic amino acid derivative that has garnered significant attention in pharmaceutical and biochemical research. This compound, characterized by its cyclopentane backbone and trans-configuration, serves as a versatile building block in organic synthesis and drug development. Its unique structural features make it a valuable intermediate for designing peptidomimetics and bioactive molecules, addressing modern challenges in drug discovery and enzyme inhibition.

Recent trends in scientific literature highlight the growing interest in non-proteinogenic amino acids like trans-2-aminocyclopentanecarboxylic acid. Researchers are exploring its potential in modulating protein-protein interactions and enhancing metabolic stability of therapeutic peptides. A 2023 study published in the Journal of Medicinal Chemistry emphasized its role in improving oral bioavailability of peptide-based drugs—a key focus area for pharmaceutical companies tackling drug delivery challenges.

The compound's stereochemical purity (trans-configuration) is critical for its biological activity. Advanced chiral synthesis methods, including asymmetric hydrogenation and enzymatic resolution, have been developed to produce high-purity trans-2-aminocyclopentanecarboxylic acid. These innovations align with the industry's push toward green chemistry and sustainable manufacturing—topics frequently searched in academic and industrial forums.

In computational chemistry, 40482-05-1 serves as a model compound for studying conformational restrictions in cyclic systems. Molecular docking simulations reveal its ability to mimic β-turn structures in proteins, explaining its utility in designing GPCR-targeted therapeutics. This application resonates with current searches about structure-based drug design and computational biology tools.

Analytical characterization of trans-2-aminocyclopentanecarboxylic acid typically involves HPLC-MS and NMR spectroscopy, with particular emphasis on distinguishing its stereoisomers. The compound's zwitterionic nature at physiological pH makes it relevant for studies on membrane permeability—a hot topic in ADME research (Absorption, Distribution, Metabolism, Excretion).

Emerging applications include its use as a precursor for macrocyclic compounds in cancer immunotherapy and as a scaffold for metal-chelating agents in diagnostic imaging. These developments respond to frequent queries about next-generation therapeutics and molecular imaging probes in medical research databases.

From a commercial perspective, suppliers often list CAS 40482-05-1 alongside related search terms like cyclopentane amino acid derivatives and constrained amino acid analogs. The compound's storage stability and solubility profiles (notably in aqueous and polar organic solvents) are frequently documented in technical datasheets to assist formulation scientists.

Ongoing research explores the compound's potential in neurological disorders, particularly as a modulator of neurotransmitter receptors. This aligns with rising public interest in neurodegenerative disease treatments and blood-brain barrier penetration strategies—subjects generating substantial traffic in scientific search engines.

In summary, trans-2-aminocyclopentanecarboxylic acid (CAS No. 40482-05-1) represents a multifaceted tool for modern chemical biology, bridging gaps between structural chemistry, therapeutic development, and computational modeling. Its continued study addresses pressing questions in medicinal chemistry while offering solutions to real-world challenges in biopharmaceutical innovation.

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