• 1. Residue-based program of a β-peptoid twisted strand shape via a cyclopentane constraint
  Jungyeon Kim,Hiroka Kobayashi,Marin Yokomine,Yota Shiratori,Takumi Ueda,Koh Takeuchi,Koji Umezawa,Daisuke Kuroda,Kouhei Tsumoto,Jumpei Morimoto,Shinsuke Sando Org. Biomol. Chem. 2022 20 6994

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Beta amino acids and derivatives

Comprehensive Guide to (1R,2R)-2-aminocyclopentanecarboxylic acid (CAS No. 136315-77-0): Properties, Applications, and Market Insights

(1R,2R)-2-aminocyclopentanecarboxylic acid (CAS No. 136315-77-0) is a chiral non-proteinogenic amino acid with significant potential in pharmaceutical and biochemical research. This compound, often referred to as a cyclopentane-based amino acid derivative, has garnered attention due to its unique structural properties and versatile applications. Researchers and industry professionals frequently search for terms like "(1R,2R)-2-aminocyclopentanecarboxylic acid synthesis", "CAS 136315-77-0 applications", and "chiral amino acid derivatives", reflecting its growing importance in scientific circles.

The molecular structure of (1R,2R)-2-aminocyclopentanecarboxylic acid features a cyclopentane ring with both amino and carboxylic acid functional groups, making it a valuable building block in peptide modification and drug design. Its chirality at both carbon centers (1R,2R configuration) makes it particularly interesting for creating enantiomerically pure compounds. Current trends in green chemistry and sustainable synthesis have increased demand for efficient production methods of such specialty amino acids, with many researchers exploring enzymatic synthesis routes and catalytic asymmetric methods.

In pharmaceutical applications, (1R,2R)-2-aminocyclopentanecarboxylic acid serves as a key intermediate for developing novel bioactive compounds. Its constrained cyclic structure influences peptide conformation, making it valuable for creating peptidomimetics that can mimic natural peptides while offering improved metabolic stability. The compound's potential in neurological research has been particularly noted, with studies investigating its role in modulating neurotransmitter systems. These applications align with current industry focus on central nervous system (CNS) drug discovery and neurodegenerative disease research.

The biochemical properties of CAS 136315-77-0 make it suitable for various bioconjugation techniques. Its amino and carboxyl groups allow for selective modifications, enabling the creation of fluorescent probes, biomarkers, and targeted drug delivery systems. Recent advancements in click chemistry and bioorthogonal reactions have further expanded its utility in creating complex molecular architectures for biological studies. These applications respond to the growing need for precision medicine tools and molecular imaging agents in modern healthcare.

From a commercial perspective, the market for chiral amino acid derivatives like (1R,2R)-2-aminocyclopentanecarboxylic acid has seen steady growth, driven by increasing demand from pharmaceutical and biotechnology sectors. Suppliers often highlight its high purity grades and custom synthesis options to meet diverse research needs. The compound's relevance in peptide therapeutics development aligns with the booming market for biologics and personalized medicine solutions. Industry reports suggest particular interest from companies specializing in neurological disorders and metabolic disease research.

Quality control and characterization of (1R,2R)-2-aminocyclopentanecarboxylic acid typically involve advanced analytical techniques such as chiral HPLC, mass spectrometry, and NMR spectroscopy. These methods ensure the compound meets stringent purity requirements for research applications. The scientific community continues to explore improved analytical protocols for such specialty chemicals, reflecting broader trends toward quality-by-design approaches in chemical manufacturing.

Future research directions for CAS 136315-77-0 may include exploring its potential in artificial enzyme design and catalytic systems, leveraging its unique stereochemistry. The compound's compatibility with solid-phase peptide synthesis (SPPS) makes it attractive for combinatorial chemistry approaches. These developments align with current interests in high-throughput screening and drug discovery acceleration technologies. As the field of structural biology advances, the demand for such specialized building blocks is expected to grow significantly.

For researchers working with (1R,2R)-2-aminocyclopentanecarboxylic acid, proper handling and storage recommendations include protection from moisture and maintenance at controlled temperatures. While not classified as hazardous, standard laboratory precautions for amino acid derivatives should be followed. The compound's stability profile makes it suitable for various chemical transformations and bioconjugation reactions, contributing to its versatility in research applications.

In conclusion, (1R,2R)-2-aminocyclopentanecarboxylic acid (CAS No. 136315-77-0) represents an important tool in modern chemical and biological research. Its unique structural features, combined with growing applications in drug discovery and biotechnology, ensure its continued relevance in scientific investigations. As research trends evolve toward more targeted therapies and precision medicine, this chiral amino acid derivative will likely play an increasingly significant role in advancing scientific knowledge and therapeutic development.

• 64191-14-6((1S,2R)-2-Aminocyclopentanecarboxylic acid)
• 40482-05-1(trans-2-aminocyclopentanecarboxylic acid)
• 763057-00-7(Cyclopentanecarboxylicacid, 2-amino-4-ethyl-, (1R,2S,4S)-rel-)
• 156406-14-3(Cyclopentanecarboxylic acid, 2-amino-5-methyl-, (1alpha,2alpha,5beta)- (9CI))
• 757186-25-7(Cyclopentanecarboxylicacid, 2-amino-3-methyl-, (1S,2S,3R)-)
• 64191-13-5((1S,2S)-2-aminocyclopentanecarboxylic acid)
• 122672-46-2((1R,2S)-2-Aminocyclopentanecarboxylic acid)
• 3814-46-8(2-aminocyclopentanecarboxylic acid)
• 37910-65-9(cis-2-aminocyclopentanecarboxylic acid)
• 156406-13-2(Cyclopentanecarboxylic acid, 2-amino-5-methyl-, (1alpha,2alpha,5alpha)- (9CI))