• 1. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
• 2. Esterase-responsive polymeric prodrug-based tumor targeting nanoparticles for improved anti-tumor performance against colon cancer?
  Gang Pan,Yi-jie Bao,Jie Xu,Tao Liu,Cheng Liu,Yan-yan Qiu,Xiao-jing Shi,Hui Yu,Ting-ting Jia,Xia Yuan,Ze-ting Yuan,Yi-jun Cao RSC Adv., 2016,6, 42109-42119
• 3. Fe3O4 nanoclusters highly dispersed on a porous graphene support as an additive for improving the hydrogen storage properties of LiBH4?
  Guang Xu,Wei Zhang,Ying Zhang,Xiaoxia Zhao,Ping Wen,Di Ma RSC Adv., 2018,8, 19353-19361
• 4. Emulsifier-free, organotellurium-mediated living radical emulsion polymerization (emulsion TERP) of styrene: poly(dimethylaminoethyl methacrylate) macro-TERP agent?
  Yukiya Kitayama Polym. Chem., 2014,5, 2784-2792
• 5. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Imidazoles

Ethyl 4-methyl-1H-imidazole-2-carboxylate (CAS No. 40253-44-9): A Versatile Intermediate in Modern Chemical Biology and Medicinal Chemistry

Ethyl 4-methyl-1H-imidazole-2-carboxylate, identified by its unique chemical identifier CAS No. 40253-44-9, represents a significant compound in the realm of chemical biology and medicinal chemistry. This versatile intermediate, characterized by its Ethyl 4-methyl-1H-imidazole-2-carboxylate structure, has garnered considerable attention due to its utility in synthesizing a wide array of pharmacologically active molecules. The compound's imidazole core, a heterocyclic aromatic structure, is a cornerstone in the development of drugs targeting various biological pathways.

The imidazole ring in Ethyl 4-methyl-1H-imidazole-2-carboxylate is particularly noteworthy for its role in medicinal chemistry. Imidazole derivatives are well-documented for their broad spectrum of biological activities, including antifungal, antibacterial, and anti-inflammatory properties. The presence of the ethyl ester group at the carboxyl position enhances the compound's reactivity, making it an invaluable building block for further functionalization. This feature has been leveraged in recent years to develop novel therapeutic agents with enhanced efficacy and reduced side effects.

Recent advancements in synthetic methodologies have further highlighted the importance of Ethyl 4-methyl-1H-imidazole-2-carboxylate in drug discovery. Researchers have employed innovative strategies to optimize the synthesis of this intermediate, leading to more efficient and scalable production processes. For instance, catalytic hydrogenation techniques have been refined to improve yield and purity, reducing the environmental impact of manufacturing processes. These developments align with the growing emphasis on green chemistry principles in pharmaceutical research.

The applications of Ethyl 4-methyl-1H-imidazole-2-carboxylate extend beyond traditional drug development. In chemical biology, this compound serves as a critical scaffold for studying enzyme inhibition and receptor binding mechanisms. Its structural flexibility allows researchers to modify various functional groups, enabling the creation of tailored molecules for high-throughput screening assays. Such assays are instrumental in identifying lead compounds for further optimization.

One particularly exciting area of research involves the use of Ethyl 4-methyl-1H-imidazole-2-carboxylate in the development of antiviral agents. The imidazole core has been shown to interact with viral proteases and polymerases, making it a promising target for designing inhibitors. Recent studies have demonstrated the efficacy of imidazole derivatives in inhibiting replication cycles of RNA viruses, including those responsible for emerging infectious diseases. This underscores the compound's potential as a therapeutic agent against a wide range of viral pathogens.

In addition to its antiviral applications, Ethyl 4-methyl-1H-imidazole-2-carboxylate has found utility in oncology research. The ability to modulate biological pathways associated with cancer cell proliferation has led to the development of novel chemotherapeutic agents. By incorporating this intermediate into drug candidates, researchers have identified molecules that exhibit potent anti-cancer activity while maintaining favorable pharmacokinetic profiles. These findings highlight the compound's role in addressing unmet medical needs in oncology.

The synthesis and application of Ethyl 4-methyl-1H-imidazole-2-carboxylate also contribute to our understanding of molecular recognition processes. The compound's interaction with biological targets provides insights into binding affinities and enzyme kinetics, which are essential for rational drug design. Advanced computational methods, such as molecular dynamics simulations and quantum mechanical calculations, have been employed to elucidate these interactions at a molecular level. Such studies not only enhance our knowledge of drug-receptor interactions but also inform the design of next-generation therapeutics.

As the field of chemical biology continues to evolve, Ethyl 4-methyl-1H-imidazole-2-carboxylate is expected to remain a cornerstone intermediate in medicinal chemistry research. Its versatility and reactivity make it an indispensable tool for synthesizing novel compounds with therapeutic potential. Furthermore, ongoing research efforts aim to expand its applications into new areas, such as regenerative medicine and neurodegenerative disease treatment. The compound's adaptability ensures its continued relevance in addressing complex biological challenges.

In conclusion, Ethyl 4-methyl-1H-imidazole-2-carboxylate (CAS No. 40253-44-9) stands as a testament to the importance of specialized intermediates in advancing pharmaceutical research and development. Its unique structural features and broad applicability underscore its significance as a building block for innovative therapeutics. As scientific understanding progresses and new methodologies emerge, this compound will undoubtedly play an integral role in shaping the future of chemical biology and medicinal chemistry.

• 33543-78-1(2-Carboethoxyimidazole)
• 87326-25-8(2-Methyl-1H-imidazole-4-carboxylic acid ethyl ester)
• 144167-57-7(1H-Imidazole-2,5-dicarboxylicacid, 2-ethyl 5-methyl ester)
• 89994-86-5(1H-Imidazole-2-carboxylic acid, 4-pentyl-, ethyl ester)
• 70631-93-5(5-methyl-1H-imidazole-2-carboxylic acid)
• 1171124-65-4(Ethyl 5-ethyl-1H-imidazole-2-carboxylate)
• 701292-71-9(1H-Imidazole-5-carboxylicacid, 2-(methoxymethyl)-, methyl ester)
• 112987-01-6(1H-Imidazole-2-carboxylicacid, 5-ethenyl-, ethyl ester)
• 40253-45-0(methyl 5-methyl-1H-imidazole-2-carboxylate)
• 97602-72-7(Methyl 2-methyl-1H-imidazole-5-carboxylate)