Production Method 1

66-72-8

3990-65-6

82-82-6

Reaction Conditions

1.1 Solvents: Water ;  1 h, rt
1.2 Reagents: Potassium tert-butoxide Solvents: Dimethyl sulfoxide ,  Tetrahydrofuran ;  2 h, reflux

Reference

Oxidative Dearomatization of PLP in Thiamin Pyrimidine Biosynthesis in Candida albicans

Mondal, Anushree ; et al, Journal of the American Chemical Society, 2023, 145(8), 4421-4430

Production Method 2

634-25-3

3990-65-6

82-82-6

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: Iron
1.2 Reagents: Alkaline phosphatase
2.1 Solvents: Water ;  1 h, rt
2.2 Reagents: Potassium tert-butoxide Solvents: Dimethyl sulfoxide ,  Tetrahydrofuran ;  2 h, reflux

Reference

Oxidative Dearomatization of PLP in Thiamin Pyrimidine Biosynthesis in Candida albicans

Mondal, Anushree ; et al, Journal of the American Chemical Society, 2023, 145(8), 4421-4430

Production Method 3

54-47-7

3990-65-6

82-82-6

Reaction Conditions

1.1 Reagents: Hydroxyamine hydrochloride ,  Hydrochloric acid Solvents: Water
2.1 -
3.1 Solvents: Water ;  1 h, rt
3.2 Reagents: Potassium tert-butoxide Solvents: Dimethyl sulfoxide ,  Tetrahydrofuran ;  2 h, reflux

Reference

Oxidative Dearomatization of PLP in Thiamin Pyrimidine Biosynthesis in Candida albicans

Mondal, Anushree ; et al, Journal of the American Chemical Society, 2023, 145(8), 4421-4430

4-Pyridinecarbonitrile, 3-hydroxy-5-(hydroxymethyl)-2-methyl- Raw materials

• 3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde
• 4-Pyridinecarboxaldehyde,3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]-, oxime
• Pyridoxal phosphate

4-Pyridinecarbonitrile, 3-hydroxy-5-(hydroxymethyl)-2-methyl- Preparation Products

• 4-Pyridinecarbonitrile, 3-hydroxy-5-(hydroxymethyl)-2-methyl- (3990-65-6)
• 4-Pyridoxic Acid (82-82-6)

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