Cas no 38647-11-9 (Triptonide)
Triptonide is a diterpenoid compound derived from the traditional medicinal plant Tripterygium wilfordii. It exhibits notable biological activity, particularly as a potent anti-inflammatory and immunosuppressive agent. Research highlights its ability to inhibit NF-κB signaling pathways, making it a candidate for studying autoimmune and inflammatory conditions. Triptonide also demonstrates potential antitumor properties by suppressing cell proliferation and inducing apoptosis in certain cancer cell lines. Its high bioavailability and low molecular weight enhance its utility in pharmacological research. Due to its selective mechanism of action, triptonide serves as a valuable tool compound for investigating molecular targets in immunology and oncology.
Triptonide structure
Product Name:Triptonide
CAS No:38647-11-9
MF:C20H22O6
MW:358.385086536407
MDL:MFCD00210566
CID:54899
PubChem ID:329824957
Update Time:2025-06-07
Triptonide Chemical and Physical Properties
Names and Identifiers
-
- Triptonide
- (3bS,4aS,5aS,6aS,7aS,7bS,8aS,8bS)-6a-Isopropyl-8b-methyl-3b,4,4a,7a,7b,8b,9,10-octahydrotrisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1,6(3H,6aH)-dione
- TRIPTONIDE(P) PrintBack
- 14-Deoxy-14-oxotriptolide
- l-triptonide
- NSC 165677
- PG 492
- Triptolide,14-deoxy-14-oxo
- 14-deoxy-14-oxo-triptolide
- (-)-triptonide
- Spectrum_001724
- SpecPlus_000568
- Spectrum2_000477
- Spectrum5_001806
- KBioSS_002204
- DivK1c_006664
- SPBio_000614
- Triptonide, >=98% (HPLC)
- KBio2_007340
- KBio2_004772
- KBio2_002204
- KBio1_001608
- BCP26007
- NSC165677
- NCI60_001273
- AB0035809
- ST24050308
- N2
- s9416
- Y0208
- N2407
- (5bS,6aS,7aS,8aS,9aS,9bS,10aS,10bS)-8a-Isopropyl-10b-methyl-1,5b,6,6a,8a,9a,9b,10b-octahydrotris(oxireno)[2',3':4b,5;2'',3'':6,7;2''',3''':8a,9]phenanthro[1,2-c]furan-3,8(2H,5H)-dione
- CCG-38708
- Q-100449
- DTXSID801317412
- Triptolide, 14-deoxy-14-oxo-
- 38647-11-9
- SCHEMBL4884926
- CHEMBL205190
- AKOS015896754
- EX-A7744
- CS-0318
- (5bS,6aS,7aS,8aS,9aS,9bS,10aS,10bS)-8a-isopropyl-10b-methyl-2,5,5b,6,6a,9a,9b,10b-octahydrotris(oxireno)[2',3':4b,5;2'',3'':6,7;2''',3''':8a,9]phenanthro[1,2-c]furan-3,8(1H,8aH)-dione
- HY-32736
- CHEBI:132267
- NSC-165677
- (3bS,4aS,5aS,6aS,7aS,7bS,8aS,8bS)-6a-isopropyl-8b-methyl-3b,4,4a,7a,7b,8b,9,10-octahydrotrisoxireno[6,7:8a,9:4b,5]phenanthro[1,2-c]furan-1,6(3H,6aH)-dione
- Trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1,6(3H,6aH)-dione,3b,4,4a,7a,7b,8b,9,10-octahydro-8b-methyl-6a-(1-methylethyl)-,(3bS,4aS,5aS,6aS,7aS,7bS,8aS,8bS)-
- (1S,2S,4S,5S,7S,9S,11S,13S)-1-methyl-7-propan-2-yl-3,6,10,16-tetraoxaheptacyclo[11.7.0.02,4.02,9.05,7.09,11.014,18]icos-14(18)-ene-8,17-dione
- SWOVVKGLGOOUKI-ZHGGVEMFSA-N
- (1S,2S,4S,5S,7S,9S,11S,13S)-1-methyl-7-propan-2-yl-3,6,10,16-tetraoxaheptacyclo(11.7.0.02,4.02,9.05,7.09,11.014,18)icos-14(18)-ene-8,17-dione
- (3bS,4aS,5aS,6aS,7aS,7bS,8aS,8bS)-6a-isopropyl-8b-methyl-3b,4,4a,7a,7b,8b,9,10-octahydrotrisoxireno(6,7:8a,9:4b,5)phenanthro(1,2-c)furan-1,6(3H,6aH)-dione
- (1S,2S,4S,5S,7S,9S,11S,13S)-7-ISOPROPYL-1-METHYL-3,6,10,16-TETRAOXAHEPTACYCLO[11.7.0.0(2),?.0(2),?.0?,?.0?,(1)(1).0(1)?,(1)?]ICOS-14(18)-ENE-8,17-DIONE
-
- MDL： MFCD00210566
- Inchi： 1S/C20H22O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14H,4-7H2,1-3H3/t11-,12-,13-,14-,17-,18-,19+,20+/m0/s1
- InChI Key： SWOVVKGLGOOUKI-ZHGGVEMFSA-N
- SMILES： O1[C@H]2[C@H]3[C@@](C(C)C)(C([C@]45[C@H](C[C@H]6C7COC(C=7CC[C@]6(C)[C@@]142)=O)O5)=O)O3
Computed Properties
- Exact Mass: 358.14200
- Monoisotopic Mass: 358.14163842 g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 6
- Heavy Atom Count: 26
- Rotatable Bond Count: 1
- Complexity: 860
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 8
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Molecular Weight: 358.4
- Surface Charge: 0
- Tautomer Count: nothing
- XLogP3: 0.7
- Topological Polar Surface Area: 81
Experimental Properties
- Color/Form: Powder
- Density: 1.48
- Melting Point: No data available
- Boiling Point: 581.1±50.0 °C at 760 mmHg
- Flash Point: 257.8±30.2 °C
- Refractive Index: 1.637
- Solubility: In vitro: DMSO solubility 50 mg/ml (139.51 mm; need ultrasonic)
- PSA: 80.96000
- LogP: 1.31130
Triptonide Security Information
-
Symbol:
- Signal Word：Danger
- Hazard Statement： H300 + H330-H361f
- Warning Statement： P201-P260-P284-P301+P310+P330-P304+P340+P310-P403+P233
- Hazardous Material transportation number：UN 2811 6.1 / PGII
- WGK Germany：3
- Hazard Category Code： 26/28-62
- Safety Instruction： 28-36/37-45
-
Hazardous Material Identification：
- Storage Condition：2-8°C
Triptonide Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| MedChemExpress | HY-32736-10mM*1mLinDMSO |
Triptonide |
38647-11-9 | 99.87% | 10mM*1mLinDMSO |
￥2251 | 2023-07-26 | |
| MedChemExpress | HY-32736-10mg |
Triptonide |
38647-11-9 | 99.87% | 10mg |
￥2046 | 2025-04-16 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | T125970-10mg |
Triptonide |
38647-11-9 | ≥98% | 10mg |
￥582.90 | 2023-08-31 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | T125970-5mg |
Triptonide |
38647-11-9 | ≥98% | 5mg |
￥575.90 | 2023-08-31 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | T125970-50mg |
Triptonide |
38647-11-9 | ≥98% | 50mg |
￥2471.90 | 2023-08-31 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | T125970-25mg |
Triptonide |
38647-11-9 | ≥98% | 25mg |
￥1315.90 | 2023-08-31 | |
| HE FEI BO MEI SHENG WU KE JI YOU XIAN ZE REN GONG SI | BZP0773-20mg |
Triptonide |
38647-11-9 | HPLC≥98% | 20mg |
￥1380元 | 2023-09-15 | |
| ChemFaces | CFN99134-20mg |
Triptonide |
38647-11-9 | >=98% | 20mg |
$188 | 2021-07-22 | |
| S e l l e c k ZHONG GUO | S9416-1mg |
Triptonide |
38647-11-9 | 99.81% | 1mg |
￥1204.68 | 2023-09-15 | |
| SHANG HAI YI EN HUA XUE JI SHU Co., Ltd. | R027632-10mg |
Triptonide |
38647-11-9 | 98% | 10mg |
￥2127 | 2022-06-14 |
Triptonide Related Literature
-
Xiufeng Liu,Kai Wang,Ningjun Duan,Yan Lan,Pengcheng Ma,Heng Zheng,Weijuan Zheng,Jiahuang Li,Zi-chun Hua RSC Adv. 2015 5 34572
-
Rongjie Zhuo,Liangxiao Zhang,Li Wang,Guoshun Shan,Qianxu Yang,Xiaoyan Yuan,Hongbin Xiao Anal. Methods 2013 5 2046
-
Hongrui Zhang,Haifeng Li,Jijun Xue,Rui Chen,Ying Li,Yu Tang,Chunxin Li Org. Biomol. Chem. 2014 12 732
-
Bing Zhou,Xiaomei Li,Huanyu Tang,Zehong Miao,Huijin Feng,Yuanchao Li Org. Biomol. Chem. 2011 9 3176
-
Zhao-Li Zhou,Ya-Xi Yang,Jian Ding,Yuan-Chao Li,Ze-Hong Miao Nat. Prod. Rep. 2012 29 457
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