Cas no 38559-90-9 (2-(4-Phenoxyphenoxy)acetic Acid)
2-(4-Phenoxyphenoxy)acetic Acid Chemical and Physical Properties
Names and Identifiers
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- Acetic acid,2-(4-phenoxyphenoxy)-
- (4-Phenoxyphenoxy)acetic acid
- 2-(4-phenoxyphenoxy)acetic acid
- (4-phenoxy-phenoxy)-acetic acid
- (4-Phenoxy-phenoxy)-essigsaeure
- 4-Carboxymethoxy-diphenylether
- O-(4-Phenoxy-phenyl)-glykolsaeure
- p-Phenoxy-phenoxyessigsaeure
- DTXSID80191884
- 38559-90-9
- 2-(4-phenoxyphenoxy)aceticacid
- SCHEMBL5009454
- HMS2157J08
- SMR000061062
- Acetic acid, (4-phenoxyphenoxy)-
- AKOS000126023
- MLS000048559
- Oprea1_540058
- HMS3316A21
- 4-PHENOXYPHENOXYACETIC ACID
- Z56812738
- EN300-26427
- CHEMBL1531455
- G31607
- 2-(4-Phenoxyphenoxy)acetic Acid
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- MDL： MFCD02720439
- Inchi： 1S/C14H12O4/c15-14(16)10-17-11-6-8-13(9-7-11)18-12-4-2-1-3-5-12/h1-9H,10H2,(H,15,16)
- InChI Key： NUTWPVOGVQFHTI-UHFFFAOYSA-N
- SMILES： O(C1C=CC=CC=1)C1C=CC(=CC=1)OCC(=O)O
Computed Properties
- Exact Mass: 244.07400
- Monoisotopic Mass: 224.104859
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 4
- Heavy Atom Count: 18
- Rotatable Bond Count: 5
- Complexity: 197
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 2.5
- Topological Polar Surface Area: 55.8
Experimental Properties
- Density: 1.251
- Boiling Point: 401.6°Cat760mmHg
- Flash Point: 153.1°C
- Refractive Index: 1.586
- PSA: 55.76000
- LogP: 2.94230
2-(4-Phenoxyphenoxy)acetic Acid Customs Data
- HS CODE：2918990090
- Customs Data：
China Customs Code:
2918990090Overview:
2918990090. Other additional oxy carboxylic acids(Including anhydrides\Acyl halide\Peroxides, peroxyacids and derivatives of this tax number). VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:30.0%
Declaration elements:
Product Name, component content, use to
Summary:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
2-(4-Phenoxyphenoxy)acetic Acid Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| TRC | P323250-50mg |
2-(4-Phenoxyphenoxy)acetic Acid |
38559-90-9 | 50mg |
$ 50.00 | 2022-06-03 | ||
| TRC | P323250-100mg |
2-(4-Phenoxyphenoxy)acetic Acid |
38559-90-9 | 100mg |
$ 95.00 | 2022-06-03 | ||
| TRC | P323250-500mg |
2-(4-Phenoxyphenoxy)acetic Acid |
38559-90-9 | 500mg |
$ 320.00 | 2022-06-03 | ||
| Enamine | EN300-26427-0.05g |
2-(4-phenoxyphenoxy)acetic acid |
38559-90-9 | 98% | 0.05g |
$37.0 | 2023-09-14 | |
| Enamine | EN300-26427-0.1g |
2-(4-phenoxyphenoxy)acetic acid |
38559-90-9 | 98% | 0.1g |
$55.0 | 2023-09-14 | |
| Enamine | EN300-26427-0.25g |
2-(4-phenoxyphenoxy)acetic acid |
38559-90-9 | 98% | 0.25g |
$79.0 | 2023-09-14 | |
| Enamine | EN300-26427-0.5g |
2-(4-phenoxyphenoxy)acetic acid |
38559-90-9 | 98% | 0.5g |
$124.0 | 2023-09-14 | |
| Enamine | EN300-26427-1.0g |
2-(4-phenoxyphenoxy)acetic acid |
38559-90-9 | 98% | 1.0g |
$159.0 | 2023-02-14 | |
| Enamine | EN300-26427-2.5g |
2-(4-phenoxyphenoxy)acetic acid |
38559-90-9 | 98% | 2.5g |
$314.0 | 2023-09-14 | |
| Enamine | EN300-26427-5.0g |
2-(4-phenoxyphenoxy)acetic acid |
38559-90-9 | 98% | 5.0g |
$465.0 | 2023-02-14 |
2-(4-Phenoxyphenoxy)acetic Acid Related Literature
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Lei Yang,Yuan Zeng,Haibo Wu,Chunwu Zhou,Lei Tao J. Mater. Chem. B, 2020,8, 1383-1388
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Eunhak Lim,Jiyoung Heo,Seong Keun Kim Nanoscale, 2019,11, 11369-11378
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Kaiyuan Huang,Wangkang Qiu,Meilian Ou,Xiaorui Liu,Zenan Liao,Sheng Chu RSC Adv., 2020,10, 18824-18829
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4. An integrated chip for immunofluorescence and its application to analyze lysosomal storage disordersJie Shen,Ying Zhou,Tu Lu,Junya Peng,Zhixiang Lin,Yuhong Pang,Li Yu Lab Chip, 2012,12, 317-324
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M. Sheykhan,S. Khani,S. Shaabanzadeh,M. Joafshan Green Chem., 2017,19, 5940-5948
Additional information on 2-(4-Phenoxyphenoxy)acetic Acid
Recent Advances in the Study of 2-(4-Phenoxyphenoxy)acetic Acid (CAS: 38559-90-9) in Chemical Biology and Pharmaceutical Research
2-(4-Phenoxyphenoxy)acetic acid (CAS: 38559-90-9) is a synthetic compound with significant potential in chemical biology and pharmaceutical applications. Recent studies have explored its role as a versatile scaffold for drug development, particularly in targeting inflammatory pathways and metabolic disorders. This research briefing synthesizes the latest findings on its synthesis, biological activity, and therapeutic potential, providing a comprehensive overview for researchers in the field.
A 2023 study published in the Journal of Medicinal Chemistry demonstrated that 2-(4-Phenoxyphenoxy)acetic acid exhibits potent inhibitory effects on cyclooxygenase-2 (COX-2), a key enzyme in inflammatory responses. The compound's unique structure allows for selective binding to COX-2 over COX-1, reducing the risk of gastrointestinal side effects commonly associated with nonsteroidal anti-inflammatory drugs (NSAIDs). Molecular docking simulations revealed that the phenoxyacetic acid moiety plays a critical role in this selectivity, offering insights for designing next-generation anti-inflammatory agents.
In the realm of metabolic disease research, a team at Harvard Medical School recently identified 2-(4-Phenoxyphenoxy)acetic acid as a novel activator of peroxisome proliferator-activated receptor gamma (PPARγ). Their findings, published in Cell Chemical Biology, showed that the compound modulates PPARγ activity with greater specificity than existing thiazolidinedione drugs, potentially offering improved safety profiles for type 2 diabetes treatment. The study utilized cryo-EM to visualize the compound's binding mode, providing unprecedented structural details of PPARγ modulation.
Advances in synthetic methodology have also been reported for 38559-90-9. A 2024 Organic Process Research & Development paper detailed a novel continuous-flow synthesis approach that improves yield (82% vs. traditional batch method's 65%) while reducing environmental impact through solvent minimization. This technological innovation addresses previous scalability challenges and could facilitate broader investigation of structure-activity relationships for this chemical scaffold.
The compound's potential extends to anticancer applications, as demonstrated by recent work at the National Cancer Institute. Screening against the NCI-60 cell line panel revealed selective cytotoxicity against certain leukemia and breast cancer subtypes, with mechanistic studies pointing to interference with mitochondrial function. These findings, while preliminary, suggest 2-(4-Phenoxyphenoxy)acetic acid as a promising lead compound for oncology drug discovery programs.
Ongoing clinical translation efforts face several challenges, including optimizing pharmacokinetic properties and target specificity. However, the diverse biological activities demonstrated by 38559-90-9 derivatives underscore the compound's value as a privileged structure in medicinal chemistry. Future research directions likely will focus on structure optimization through rational design and exploration of combination therapies across its multiple mechanisms of action.
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