• 1. Examination of ammonia–poly(pyrrole) interactions by piezoelectric and conductivity measurements
  Analyst, 1991,116, 1125-1130
• 2. Emergence of microfluidic wearable technologies
  Joo Chuan Yeo,Kenry Lab Chip, 2016,16, 4082-4090
• 3. Dissolved oxygen sensor based on fluorescence quenching of oxygen-sensitive ruthenium complexes immobilized in sol–gel-derived porous silica coatings
  Analyst, 1996,121, 785-788
• 4. Excellent electrochemical performance of LiFe0.4Mn0.6PO4 microspheres produced using a double carbon coating process?
  Yong Ping Huang,Tao Tao,Zheng Chen,Wei Han,Ying Wu,Chunjiang Kuang,Shaoxiong Zhou,Ying Chen J. Mater. Chem. A, 2014,2, 18831-18837
• 5. Excimer–monomer switch: a reaction-based approach for selective detection of fluoride?
  Qiao Song,Angela Bamesberger,Lingyun Yang,Haley Houtwed,Haishi Cao Analyst, 2014,139, 3588-3592

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenylacetamides

2,2-Difluoro-2-phenylacetamide (CAS No. 383-19-7): An Overview of Its Properties, Applications, and Recent Research

2,2-Difluoro-2-phenylacetamide (CAS No. 383-19-7) is a versatile compound that has garnered significant attention in the fields of organic chemistry, pharmaceuticals, and materials science. This compound is characterized by its unique structure, which includes a phenyl group and two fluorine atoms attached to the acetamide moiety. The combination of these functional groups imparts distinct chemical and physical properties that make it a valuable building block in various applications.

The molecular formula of 2,2-difluoro-2-phenylacetamide is C₉H₇F₂NO, and its molecular weight is approximately 185.15 g/mol. The compound is a white crystalline solid at room temperature and exhibits good solubility in common organic solvents such as dichloromethane, acetone, and ethanol. These properties make it suitable for use in a wide range of chemical reactions and processes.

In the context of pharmaceutical research, 2,2-difluoro-2-phenylacetamide has shown promise as a potential drug candidate due to its ability to modulate various biological targets. Recent studies have explored its antimicrobial and anti-inflammatory properties, highlighting its potential in the development of novel therapeutics. For instance, a study published in the *Journal of Medicinal Chemistry* in 2021 demonstrated that derivatives of 2,2-difluoro-2-phenylacetamide exhibited potent activity against multidrug-resistant bacteria, making them attractive candidates for the treatment of infectious diseases.

Beyond its pharmaceutical applications, 2,2-difluoro-2-phenylacetamide has also found use in the development of advanced materials. The presence of fluorine atoms imparts unique electronic and surface properties to the compound, which can be leveraged in the synthesis of functional polymers and coatings. A notable example is its use in the preparation of fluorinated polymers with enhanced hydrophobicity and chemical resistance. These materials have applications in areas such as water treatment, electronics, and protective coatings.

The synthesis of 2,2-difluoro-2-phenylacetamide can be achieved through several routes, each with its own advantages and limitations. One common method involves the reaction of phenylacetonitrile with difluorocarbene followed by hydrolysis to form the acetamide. Another approach involves the direct fluorination of phenylacetic acid using selective fluorinating agents such as Selectfluor? (1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate)). These synthetic strategies have been optimized to improve yield and purity, making large-scale production feasible.

Recent advancements in computational chemistry have also contributed to a deeper understanding of the structure-property relationships of 2,2-difluoro-2-phenylacetamide. Molecular dynamics simulations and quantum mechanical calculations have provided insights into its electronic structure and reactivity patterns. These computational tools are invaluable for predicting the behavior of the compound in different environments and for designing new derivatives with tailored properties.

In terms of safety and handling, 2,2-difluoro-2-phenylacetamide should be handled with care to avoid exposure to skin or inhalation. It is recommended to work with this compound under a fume hood and to use appropriate personal protective equipment (PPE) such as gloves and safety goggles. Additionally, proper disposal methods should be followed to ensure environmental safety.

The future outlook for 2,2-difluoro-2-phenylacetamide is promising as ongoing research continues to uncover new applications and optimize existing ones. Its unique combination of functional groups makes it a versatile platform for innovation in both pharmaceuticals and materials science. As researchers delve deeper into its properties and potential uses, it is likely that this compound will play an increasingly important role in advancing scientific knowledge and technological capabilities.

• 14204-07-0(2-Fluoro-2-phenylacetamide)
• 1375472-86-8(Benzeneacetamide, 3-bromo-α,α-difluoro-)
• 40626-55-9(2-(4-chlorophenyl)-2,2-difluoroacetamide)
• 1375473-36-1(2-(4-Bromophenyl)-2,2-difluoroacetamide)
• 1375473-89-4(2,2-difluoro-2-(2-methylphenyl)acetamide)
• 1375472-30-2(2,2-difluoro-2-(4-fluorophenyl)acetamide)
• 1375471-74-1(2-(2-bromophenyl)-2,2-difluoroacetamide)
• 1375471-77-4(Benzeneacetamide, α,α,3-trifluoro-)
• 1375472-28-8(Benzeneacetamide, α,α,2-trifluoro-)
• 780769-48-4(2-(3-Chlorophenyl)-2,2-difluoroacetamide)