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• 3. An approach to 7-aza-1-phosphanorbornane complexes: strain promoted rearrangement of 1-iminylphosphirane complexes and cycloaddition with olefins?
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers Anisoles

Comprehensive Overview of 2,3,6-Trimethoxyphenylboronic Acid (CAS No. 380430-67-1): Properties, Applications, and Industry Insights

2,3,6-Trimethoxyphenylboronic acid (CAS No. 380430-67-1) is a specialized boronic acid derivative widely recognized for its role in organic synthesis and pharmaceutical research. With the molecular formula C₉H₁₃BO₅, this compound features a phenyl ring substituted with three methoxy groups at the 2, 3, and 6 positions, along with a boronic acid functional group. Its unique structure makes it a valuable building block for Suzuki-Miyaura cross-coupling reactions, a topic frequently searched by chemists exploring palladium-catalyzed reactions.

The growing demand for 2,3,6-Trimethoxyphenylboronic acid is driven by its applications in drug discovery, particularly in the synthesis of biologically active molecules. Researchers often inquire about its solubility (e.g., in THF or DMSO) and stability under various conditions, as these factors are critical for reaction optimization. Recent studies highlight its utility in developing anticancer agents and enzyme inhibitors, aligning with the trending focus on targeted therapies and precision medicine.

From an industrial perspective, CAS 380430-67-1 is gaining traction due to its compatibility with green chemistry principles. Questions about scalable synthesis methods or eco-friendly purification techniques reflect the market's shift toward sustainable practices. Analytical data, such as NMR spectra (1H/13C) and HPLC purity, are also highly sought after, as evidenced by frequent searches in academic and patent literature.

Beyond pharmaceuticals, 2,3,6-Trimethoxyphenylboronic acid is explored in material science for designing organic electronic components. Its ability to form stable covalent bonds with diols (via boronate ester formation) makes it relevant for sensor development, a hot topic in wearable technology and diagnostic devices. Users often search for storage recommendations (e.g., inert atmosphere, low temperature) to maintain its reactivity.

Quality control is another critical aspect, with frequent queries about certificates of analysis (CoA) and supplier reliability. The compound’s melting point (~100–105°C) and spectroscopic properties are key identifiers for verification. As the industry moves toward AI-assisted molecular design, computational studies on its electronic structure and reactivity descriptors are emerging as a niche research area.

In summary, 2,3,6-Trimethoxyphenylboronic acid (CAS No. 380430-67-1) bridges multiple disciplines, from medicinal chemistry to advanced materials. Its versatility and alignment with cutting-edge research trends ensure its continued relevance in scientific and industrial applications.

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