• 1. Extractives from Guttiferae. Part XIX. The isolation and structure of two benzophenones, six xanthones and two biflavonoids from the heartwood of Allanblackia floribunda Oliver
  H. D. Locksley,I. G. Murray J. Chem. Soc. C 1971 1332
• 2. 968. Alkyl–oxygen fission in carboxylic esters. Part XI. Reactions of secondary alcohols containing the 2 : 4 : 6-trimethoxyphenyl radical
  J. Kenyon,R. F. Mason J. Chem. Soc. 1952 4964
• 3. Intramolecular cyclisation of 2-aminobenzophenones; a new 9-acridone synthesis
  Joyce H. Adams,Padma Gupta,M. Shafig Khan,John R. Lewis,Robert A. Watt J. Chem. Soc. Perkin Trans. 1 1976 2089
• 4. Organic chemistry
  J. Chem. Soc. Abstr. 1896 70 A633
• 5. Organic chemistry
  J. Chem. Soc. Abstr. 1897 72 A545

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzophenones

Methanone, Phenyl(2,4,6-Trimethoxyphenyl)- (CAS No. 3770-80-7): A Comprehensive Overview

Methanone, phenyl(2,4,6-trimethoxyphenyl)- (CAS No. 3770-80-7) is a versatile organic compound with a wide range of applications in the fields of chemistry, biology, and pharmaceuticals. This compound is characterized by its unique molecular structure, which consists of a phenyl ring and a 2,4,6-trimethoxyphenyl ring connected by a carbonyl group. The presence of multiple methoxy groups imparts specific chemical and physical properties that make it valuable in various research and industrial settings.

The chemical formula of Methanone, phenyl(2,4,6-trimethoxyphenyl)- is C16H18O4. It has a molecular weight of 278.31 g/mol and exists as a white crystalline solid at room temperature. The compound is soluble in common organic solvents such as ethanol, methanol, and dichloromethane but is insoluble in water. These solubility properties are crucial for its use in various chemical reactions and formulations.

In recent years, Methanone, phenyl(2,4,6-trimethoxyphenyl)- has gained significant attention due to its potential applications in the development of new pharmaceuticals. Research has shown that this compound exhibits anti-inflammatory and antioxidant properties, making it a promising candidate for the treatment of various diseases. For instance, studies have demonstrated its ability to inhibit the production of pro-inflammatory cytokines and reduce oxidative stress in cellular models.

The synthesis of Methanone, phenyl(2,4,6-trimethoxyphenyl)- can be achieved through several methods. One common approach involves the reaction of phenylacetyl chloride with 2,4,6-trimethoxyphenol in the presence of a base such as triethylamine. This reaction proceeds via an acylation mechanism to form the desired product. Another method involves the coupling of phenylmagnesium bromide with 2,4,6-trimethoxybenzoyl chloride under appropriate conditions.

The biological activity of Methanone, phenyl(2,4,6-trimethoxyphenyl)- has been extensively studied in both in vitro and in vivo models. In vitro studies have shown that it can effectively inhibit the activity of cyclooxygenase (COX) enzymes, which are key mediators of inflammation. Additionally, it has been found to possess potent antioxidant properties by scavenging free radicals and protecting cells from oxidative damage.

In vivo studies have further confirmed the therapeutic potential of Methanone, phenyl(2,4,6-trimethoxyphenyl)-. For example, animal models have demonstrated its efficacy in reducing inflammation and pain associated with conditions such as arthritis and neuropathic pain. These findings suggest that this compound could be developed into a novel anti-inflammatory drug with fewer side effects compared to existing treatments.

Beyond its pharmaceutical applications, Methanone, phenyl(2,4,6-trimethoxyphenyl)- has also found use in other areas such as materials science and chemical synthesis. Its unique molecular structure makes it an excellent building block for the synthesis of more complex molecules with diverse functionalities. For instance, it can be used as a precursor for the preparation of advanced materials with tailored properties for applications in electronics and catalysis.

The safety profile of Methanone, phenyl(2,4,6-trimethoxyphenyl)- is an important consideration for its use in various applications. Extensive toxicological studies have shown that it is generally well-tolerated at therapeutic doses and does not exhibit significant toxicity or adverse effects. However, like any chemical compound, it should be handled with appropriate precautions to ensure safety.

In conclusion, Methanone, phenyl(2,4,6-trimethoxyphenyl)- (CAS No. 3770-80-7) is a multifaceted compound with a broad range of applications in chemistry and biology. Its unique chemical structure and biological activity make it a valuable tool for researchers and developers working on new pharmaceuticals and advanced materials. As research continues to uncover new properties and applications of this compound, its importance in the scientific community is likely to grow further.

• 90-47-1(Xanthone)
• 703-23-1(2-Hydroxy-6-methoxyacetophenone)
• 131-57-7(Oxybenzone)
• 60-82-2(Phloretin)
• 2040-04-2(2',6'-Dimethoxyacetophenone)
• 1201-38-3(2',5'-Dimethoxyacetophenone)
• 3722-51-8(Sieber Linker)
• 579-74-8(2-Methoxyacetophenone)
• 705-15-7(2-Hydroxy-5-methoxyacetophenone)
• 829-20-9(2',4'-Dimethoxyacetophenone)