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• 2. An artificial CO-releasing metalloprotein built by histidine-selective metallation?
  Inês S. Albuquerque,Hélia F. Jeremias,Miguel Chaves-Ferreira,Dijana Matak-Vinkovic,Omar Boutureira,Carlos C. Rom?o Chem. Commun., 2015,51, 3993-3996
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  Luke L. Lairson,Warren W. Wakarchuk Chem. Commun., 2007, 365-367
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• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ketones
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds Ketones

1-(4-Bromophenyl)-4,4-Difluorobutane-1,3-Dione: A Comprehensive Overview

1-(4-Bromophenyl)-4,4-Difluorobutane-1,3-Dione is a highly specialized organic compound with the CAS number 371967-22-5. This compound is characterized by its unique structure, which includes a bromophenyl group attached to a butane dione backbone with two fluorine atoms at the 4-position. The combination of these functional groups makes it a versatile molecule with potential applications in various fields of chemistry and materials science.

The synthesis of 1-(4-Bromophenyl)-4,4-Difluorobutane-1,3-Dione involves a series of carefully designed organic reactions. Researchers have explored various methods to optimize the synthesis process, ensuring high yield and purity. Recent studies have focused on improving the efficiency of the reaction by employing advanced catalysts and reaction conditions. For instance, the use of microwave-assisted synthesis has been reported to significantly reduce reaction time while maintaining product quality.

The physical properties of 1-(4-Bromophenyl)-4,4-Difluorobutane-1,3-Dione are well-documented. It is a crystalline solid with a melting point of approximately 200°C and a boiling point around 350°C under standard conditions. The compound is sparingly soluble in water but exhibits good solubility in organic solvents such as dichloromethane and acetonitrile. These properties make it suitable for use in various organic synthesis reactions and as an intermediate in the production of more complex molecules.

Recent research has highlighted the potential of 1-(4-Bromophenyl)-4,4-Difluorobutane-1,3-Dione in the field of medicinal chemistry. Its structure allows for easy modification at the bromophenyl group, enabling the creation of derivatives with diverse biological activities. For example, studies have shown that certain derivatives exhibit potent anti-inflammatory and antioxidant properties. These findings suggest that this compound could serve as a valuable starting material for drug discovery programs targeting chronic inflammatory diseases.

In addition to its medicinal applications, 1-(4-Bromophenyl)-4,4-Difluorobutane-1,3-Dione has also found use in materials science. Its ability to form stable complexes with metal ions makes it a promising candidate for the development of new coordination polymers and metal-organic frameworks (MOFs). Recent experiments have demonstrated that incorporating this compound into MOFs can enhance their gas adsorption capabilities, particularly for gases such as carbon dioxide and methane.

The environmental impact of 1-(4-Bromophenyl)-4,4-Difluorobutane-1,3-Dione has also been a topic of interest in recent studies. Researchers have investigated its biodegradability and toxicity under various conditions. Initial results indicate that the compound is not highly toxic to aquatic organisms at environmentally relevant concentrations. However, further studies are needed to fully understand its long-term effects on ecosystems.

In conclusion, 1-(4-Bromophenyl)-4,4-Difluorobutane-1,3-Dione (CAS No: 371967-22-5) is a versatile compound with significant potential in multiple areas of research and industry. Its unique structure and favorable physical properties make it an attractive candidate for further exploration in medicinal chemistry, materials science, and environmental studies. As research continues to uncover new applications and insights into this compound's behavior, its role in advancing scientific knowledge is likely to grow.

• 216300-67-3(1,3-Butanedione, 4,4-difluoro-1-phenyl-, ion(1-), lithium)
• 23975-63-5(1-(2-bromophenyl)-4,4,4-trifluorobutane-1,3-dione)
• 326-06-7(Benzoyl-1,1,1-trifluoroacetone)
• 18931-61-8(1-(4-Bromophenyl)-4,4,4-trifluorobutane-1,3-dione)
• 165328-11-0(4,4-difluoro-1-(4-methylphenyl)butane-1,3-dione)
• 173974-88-4(1-(4-Bromo-phenyl)-2,2-difluoro-ethanone)
• 720-94-5(1-(4-Methylphenyl)-4,4,4-trifluorobutane-1,3-dione)
• 23975-64-6(1,3-Butanedione,1-(3-bromophenyl)-4,4,4-trifluoro-)
• 53764-99-1(4,4,4-Trifluoro-1-(3-methylphenyl)-1,3-butanedione)
• 62679-61-2(4,4-difluoro-1-phenylbutane-1,3-dione)