• 1. Examination of ammonia–poly(pyrrole) interactions by piezoelectric and conductivity measurements
  Analyst, 1991,116, 1125-1130
• 2. Ester-mediated peptide formation promoted by deep eutectic solvents: a facile pathway to proto-peptides?
  Chen-Yu Chien,Sheng-Sheng Yu Chem. Commun., 2020,56, 11949-11952
• 3. Excellent lithium ion storage property of porous MnCo2O4 nanorods?
  Peiyuan Zeng,Xiaoxiao Wang,Ming Ye,Qiuyang Ma,Jianwen Li,Wanwan Wang,Baoyou Geng,Zhen Fang RSC Adv., 2016,6, 23074-23084
• 4. Elusive 2-aminofuran Diels–Alder substrates for a straightforward synthesis of polysubstituted anilines?
  Ana G. Neo,Ana Bornadiego,Jesús Díaz,Stefano Marcaccini,Carlos F. Marcos Org. Biomol. Chem., 2013,11, 6546-6555
• 5. Fate of single walled carbon nanotubes in wetland ecosystems?
  Joseph H. Bisesi,Tara Sabo-Attwood Environ. Sci.: Nano, 2014,1, 574-583

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives Quinolines and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives
• Other Chemical Reagents Derivatization Reagents
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

Professional Introduction to Quinolin-4-ylboronic Acid (CAS No. 371764-64-6)

Quinolin-4-ylboronic acid, a compound with the chemical identifier CAS No. 371764-64-6, represents a significant advancement in the field of organic synthesis and pharmaceutical development. This boronic acid derivative, featuring a quinolin-4-yl moiety, has garnered considerable attention due to its versatile applications in cross-coupling reactions and as a key intermediate in the synthesis of biologically active molecules.

The utility of quinolin-4-ylboronic acid stems from its ability to participate in Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern synthetic organic chemistry. This reaction allows for the formation of carbon-carbon bonds under mild conditions, making it an invaluable tool for constructing complex molecular architectures. The boronic acid group in this compound facilitates these transformations by acting as a nucleophile, enabling the coupling with aryl halides or triflates to yield biaryl compounds.

In recent years, the pharmaceutical industry has increasingly leveraged boronic acids for the development of novel therapeutic agents. The quinolin-4-ylboronic acid scaffold has been explored in various drug discovery programs due to its structural versatility and potential to modulate biological pathways. For instance, derivatives of this compound have shown promise in inhibiting enzymes involved in cancer progression, highlighting its significance as a pharmacophore.

The incorporation of the quinolin-4-yl group into boronic acids offers additional advantages, including improved solubility and metabolic stability. These properties are critical for drug candidates that must navigate biological systems while maintaining efficacy. Recent studies have demonstrated that compounds incorporating this moiety exhibit enhanced binding affinity to target proteins, making them attractive for further development.

The synthesis of quinolin-4-ylboronic acid typically involves multi-step processes that require precise control over reaction conditions. Advanced synthetic methodologies have been developed to optimize yields and purity, ensuring that researchers can access high-quality starting materials for their investigations. These methods often involve palladium-catalyzed transformations and careful selection of ligands to facilitate efficient boronic acid formation.

One of the most compelling aspects of quinolin-4-ylboronic acid is its role in the development of targeted therapies. By serving as a precursor for more complex molecules, this compound enables the creation of drugs that can selectively interact with disease-causing pathways. For example, researchers have utilized derivatives of this boronic acid in the design of kinase inhibitors, which are crucial for treating cancers and inflammatory diseases.

The growing interest in green chemistry has also influenced the synthesis of quinolin-4-ylboronic acid. Efforts are underway to develop more sustainable methodologies that minimize waste and reduce energy consumption. These innovations align with broader trends in pharmaceutical research, where environmental considerations are increasingly integrated into drug development processes.

The applications of quinolin-4-ylboronic acid extend beyond pharmaceuticals into materials science and catalysis. Its ability to participate in cross-coupling reactions makes it a valuable component in the synthesis of advanced materials, such as conductive polymers and luminescent compounds. Additionally, its role as a ligand in catalytic systems has been explored, demonstrating its versatility in chemical transformations.

In conclusion, quinolin-4-ylboronic acid (CAS No. 371764-64-6) represents a cornerstone compound in modern synthetic chemistry and drug development. Its unique properties and broad applicability make it an indispensable tool for researchers working on cutting-edge therapeutics and materials science applications. As our understanding of its potential continues to grow, so too will its significance in advancing scientific innovation.

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• 376581-24-7(Quinoline-6-boronic acid)
• 371766-08-4((isoquinolin-5-yl)boronic acid)
• 144104-59-6((1H-Indol-5-yl)boronic acid)
• 147621-18-9((1H-indol-6-yl)boronic acid)
• 721401-43-0((isoquinolin-8-yl)boronic acid)
• 741253-05-4((1H-indol-3-yl)boronic acid)
• 86-58-8(quinolin-8-ylboronic acid)