• 1. Elucidation of the catalytic mechanisms of the non-haem iron-dependent catechol dioxygenases: synthesis of carba-analogues for hydroperoxide reaction intermediates
  Christopher J. Winfield,Zeyana Al-Mahrizy,Michael Gravestock,Timothy D. H. Bugg J. Chem. Soc. Perkin Trans. 1 2000 3277
• 2. Lactone synthesis activity in a site-directed mutant of an extradiol catechol dioxygenase enzyme
  Sharon Mendel,Andrew Arndt,Timothy D. H. Bugg Chem. Commun. 2005 666
• 3. Biotransformations
  Gideon Grogan Annu. Rep. Prog. Chem. Sect. B: Org. Chem. 2006 102 197
• 4. Chemical and biochemical properties of 2-hydroxypentadienoic acid, a homologue of enolpyruvic acid
  John R. Pollard,Ian M. J. Henderson,Timothy D. H. Bugg Chem. Commun. 1997 1885

• Solvents and Organic Chemicals Organic Compounds Phenylpropanoids and polyketides Phenylpropanoic acids Phenylpropanoic acids
• Solvents and Organic Chemicals Organic Compounds Phenylpropanoids and polyketides Phenylpropanoic acids

3-(2,3-Dihydroxyphenyl)propionic Acid (CAS No. 3714-73-6): A Comprehensive Scientific Profile

3-(2,3-Dihydroxyphenyl)propionic Acid (CAS 3714-73-6), a naturally occurring phenolic derivative, has garnered significant attention in biochemical and pharmaceutical research due to its unique structural properties and potential therapeutic applications. This dihydroxyphenylpropionic acid derivative belongs to the class of polyphenolic compounds, which are widely studied for their antioxidant and anti-inflammatory effects. Recent trends in scientific literature highlight growing interest in its role as a gut microbiota metabolite, particularly in the context of dietary polyphenol metabolism.

The compound's molecular structure features a propionic acid side chain attached to a catechol moiety (1,2-dihydroxybenzene), which contributes to its distinctive chemical behavior. Researchers investigating natural product chemistry and drug discovery frequently explore this molecule as a building block for more complex structures. Analytical techniques such as HPLC-MS and NMR spectroscopy are commonly employed to characterize 3714-73-6 in various biological matrices, reflecting its importance in metabolomics studies.

Current research hotspots surrounding 3-(2,3-Dihydroxyphenyl)propionic Acid include its potential as a neuroprotective agent and its involvement in mitochondrial function modulation. Scientific databases show increasing searches for "phenylpropionic acid derivatives in neurodegeneration" and "catechol metabolites in gut-brain axis," indicating strong academic interest. The compound's ability to chelate metal ions and scavenge free radicals makes it particularly relevant to studies on oxidative stress-related diseases.

In pharmaceutical applications, CAS 3714-73-6 serves as a valuable intermediate for synthesizing more complex molecules. Its bifunctional nature (containing both carboxylic acid and phenolic hydroxyl groups) allows for diverse chemical modifications, making it attractive for medicinal chemistry projects. Recent patent literature reveals its utility in developing targeted drug delivery systems, particularly for inflammatory conditions.

From a biochemical perspective, this compound participates in several metabolic pathways, including the degradation of flavonoids and lignin-derived aromatic compounds. Microbiologists studying human gut microbiota have identified 3714-73-6 as a key metabolite in the transformation of dietary polyphenols by intestinal bacteria. This connection to microbiome research aligns with current public interest in gut health and personalized nutrition.

Analytical challenges associated with 3-(2,3-Dihydroxyphenyl)propionic Acid include its stability in aqueous solutions and sensitivity to oxidation. Standard protocols for handling recommend argon atmosphere protection during storage and low-temperature preservation to maintain integrity. These precautions are particularly important for researchers conducting quantitative analysis in biological samples.

The commercial availability of CAS 3714-73-6 has expanded in recent years to meet growing research demand. Suppliers typically provide the compound with ≥95% purity, as verified by reverse-phase HPLC. Quality control specifications often include tests for heavy metal content and residual solvents, reflecting its potential use in pharmaceutical development.

Emerging applications in material science have explored the compound's potential as a biodegradable polymer precursor. Its aromatic structure and multiple functional groups make it suitable for creating sustainable materials with specific thermal and mechanical properties. This development aligns with global trends toward green chemistry and eco-friendly material design.

In conclusion, 3-(2,3-Dihydroxyphenyl)propionic Acid represents a multifaceted compound with significance across multiple scientific disciplines. From its fundamental role in plant secondary metabolism to cutting-edge applications in biomedical research, this molecule continues to reveal new dimensions of chemical and biological importance. Future research directions likely will explore its structure-activity relationships in greater depth and investigate its potential in precision medicine approaches.

• 495-78-3(3-(2-Hydroxyphenyl)propionic Acid)
• 70318-72-8(BENZENEPROPANOIC ACID, 2,5-DIHYDROXY-4-METHYL-)
• 128760-84-9(Benzenepentanoic acid, 2,5-dihydroxy-)
• 71945-73-8(4-(2-hydroxy-4-methylphenyl)butanoic acid)
• 10538-47-3((2,5-Dihydroxyphenyl)propionic acid)
• 726193-52-8(BENZENEBUTANOIC ACID, 2,5-DIHYDROXY-4-OCTADECYL-)
• 79638-23-6(4-(2,3-Dihydroxyphenyl)butyric Acid)
• 83801-01-8(3-(2,3-dihydroxyphenyl)butanoic acid)
• 141102-12-7(Benzenepentanoic acid, 3-(3-carboxypropyl)-4-hydroxy-)
• 106415-11-6(Benzenebutanoic acid, 4-hexadecyl-2,5-dihydroxy-)