Cas no 3647-69-6 (4-(2-Chloroethyl)morpholine hydrochloride)

4-(2-Chloroethyl)morpholine hydrochloride is a versatile organic compound primarily used as a key intermediate in pharmaceutical and chemical synthesis. Its morpholine ring and reactive chloroethyl group make it valuable for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and specialty chemicals. The hydrochloride salt form enhances stability and solubility, facilitating handling and storage. This compound is particularly useful in nucleophilic substitution reactions, where it serves as a precursor for further functionalization. Its consistent purity and well-defined reactivity profile ensure reliable performance in research and industrial applications, making it a preferred choice for synthetic chemists.

4-(2-Chloroethyl)morpholine hydrochloride structure

3647-69-6 structure

Product Name:4-(2-Chloroethyl)morpholine hydrochloride

CAS No:3647-69-6

MF:C₆H₁₃Cl₂NO

MW:186.079519987106

MDL:MFCD00012797

CID:44359

PubChem ID:77210

Update Time:2025-05-20

4-(2-Chloroethyl)morpholine hydrochloride Chemical and Physical Properties

Names and Identifiers

- 4-(2-Chloroethyl)morpholine hydrochloride
- N-(2-Chloroethyl) morpholine HCl
- 2-(N-Morpholino)ethyl chloride hydrochloride
- 4-(2-chloroethyl)mopholine hydrochloride
- 4-(2-Chloroethyl)-Morpholine Hydrochloride
- 2-Morpholinoethyl Chloride Hydrochloride
- N-(2-Chloroethyl)morpholine hydrochloride
- Morpholine, 4-(2-chloroethyl)-, hydrochloride
- 2-Morpholinoethylchloride hydrochloride
- 4-(2-chloroethyl)morpholine HCl
- Chloromorpholinoethane hydrochloride
- (2-Chloroethyl)morpholine hydrochloride
- 4-(2-Chloroethyl)morpholinium chloride
- Morpholine, 4-(2-chloroethyl)-, hydroc
- SCHEMBL11275
- NSC-10003
- N-chloroethyl morpholine hydrochloride
- 4-(2-chloroethyl)morpholinehydrochloride
- NBJHDLKSWUDGJG-UHFFFAOYSA-N
- CAS-3647-69-6
- 4-(2-chloroethyl)morpholine.hydrochloride
- FT-0629123
- WLN: T6N DOTJ A2G &GH
- 2-chloroethylmorpholine HCl
- N-(2-chloroethyl)morpholine HCl
- 4-(2-chloro-ethyl)-morpholine hydrochloride salt
- 4-(2-chloroethyl)morpholine HCl salt
- n-(2-chloro-ethyl)-morpholine hydrochloride
- 2-chlorethyl-morpholine hydrochloride
- N-(2-chloroethyl)morpholine HCl salt
- 4-(2-chloroethyl)morpholine;hydrochloride
- N-(chloroethyl)morpholin, hydrochloride
- BCP32227
- N-(2-chloroethyl)-morpholine HCl
- chloroethylmorpholine hydrochloride
- 4-(2-chloro-ethyl)-morpholine hydrochloride
- 2-CHLOROETHYLMORPHOLINE HYDROCHLORIDE
- 4-(2-Chloroethyl)morpholine hydrochloride, 99%
- 1-chloro-2-morpholinoethane hydrochloride
- 4-(2-chloroethyl) morpholine hydrochloride
- 4-(2-Chloroethyl)morpholine hydrochloride, purum, >=97.0% (AT)
- S9S74LB75C
- 4-(2-chloro-ethyl)morpholine hydrochloride
- 4-(2chloroethyl)morpholine hydrochloride
- 4-(2-Chloro-ethyl)-morpholine HCl
- MFCD00012797
- N-(.beta.-Chloroethyl)morpholine-hydrochloride
- AKOS009031315
- morpholinoethylchloride hydrochloride
- 4-(2-chloroethyl) morpholine HCl
- 4-(2-chloroethyl)morpholine hydrochloric acid
- chloroethylmorpholine hydrochloride salt
- F2190-0248
- N-(2-chloroethyl) morpholine hydrochloride
- NSC 46824
- Z104490276
- N-(2-Chloroethyl)morpholine hydrochloride;2-Morpholinoethylchloride hydrochloride
- W-106608
- NCGC00357150-01
- NSC10003
- 4-(2-chlorethyl)morpholine hydrochloride
- morpholinoethyl chloride hydrochloride
- AM90204
- Morpholine, (2-chloroethyl)-, hydrochloride
- 2-(morpholino)ethylchloride hydrochloride
- P16570
- DTXCID5030610
- N-(2-chloroethyl)-morpholine hydrochloride
- N-(2-choroethyl)morpholine hydrochloride
- NSC 10003
- EN300-21096
- Tox21_303894
- SB12749
- DTXSID0052043
- AI3-16221
- morpholinyl-ethyl-chloride hydrochloride
- A823264
- N-(beta-Chloroethyl)morpholine-hydrochloride
- NSC-46824
- CS-0015128
- NSC46824
- 4-(2-Chloroethyl)morpholine hydrochloride (1:1)
- AC-31125
- N-(2-Chloro-ethyl)morpholine hydrochloride
- 3647-69-6
- 4-(2-chloroethyl)morpholine hydrogen chloride
- 4-(2-chloroethyl)morpholine monohydrochloride
- 2-chloroethyl morpholine hydrochloride
- 4-(2-chloro-ethyl)-morpholine hydochloride
- STR05917
- Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1)
- 4-(2-chloroethyl)morpholine hyrdochloride
- 2-morpholino-ethyl chloride hydrochloride
- (2-chloroethyl)-morpholine hydrochloride
- EINECS 222-881-2
- 4-(2-chloroethyl)-morpholinehydrochloride
- DB-048963
- MDL： MFCD00012797
- Inchi： 1S/C6H12ClNO.ClH/c7-1-2-8-3-5-9-6-4-8;/h1-6H2;1H
- InChI Key： NBJHDLKSWUDGJG-UHFFFAOYSA-N
- SMILES： ClCCN1CCOCC1.Cl
- BRN： 3684083

Computed Properties

Exact Mass: 185.03700
Monoisotopic Mass: 185.037
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 2
Heavy Atom Count: 10
Rotatable Bond Count: 2
Complexity: 73.5
Covalently-Bonded Unit Count: 2
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count : 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Surface Charge: 0
Tautomer Count: nothing
XLogP3: nothing
Topological Polar Surface Area: 12.5

Experimental Properties

Color/Form: Uncertain
Density: 1.088
Melting Point: 183.0 to 187.0 deg-C
Boiling Point: 202.8°Cat760mmHg
Flash Point: 76.4°C
PH: 4.5-5 (10g/l, H2O, 20℃)
Water Partition Coefficient: dissolution
PSA: 12.47000
LogP: 1.29730
Sensitiveness: Hygroscopic
Solubility: Uncertain

4-(2-Chloroethyl)morpholine hydrochloride Security Information

Symbol:
Prompt：dangerous
Signal Word：Danger
Hazard Statement： H301-H312-H314-H317
Warning Statement： P280-P301 + P310-P305 + P351 + P338-P310
Hazardous Material transportation number：UN 2923 8/PG 3
WGK Germany：2
Hazard Category Code： 21-25-34-43
Safety Instruction： S26-S36/37/39-S45-S61
RTECS：QE0260000
Hazardous Material Identification：
HazardClass：8 (6.1)
PackingGroup：III
TSCA：Yes
Storage Condition：Store at room temperature
Safety Term：S26;S36/37/39;S45;S61
Packing Group：III
Packing Group：III
Risk Phrases：R21; R25; R34; R43; R52/53

4-(2-Chloroethyl)morpholine hydrochloride Customs Data

HS CODE：2934999090
Customs Data：

China Customs Code:
2934999090

Overview:

2934999090. Other heterocyclic compounds. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

Declaration elements:

Product Name, component content, use to

Summary:

2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

4-(2-Chloroethyl)morpholine hydrochloride Pricemore >>

Related Categories	No.	Product Name	Cas No.	Purity	Specification	Price	update time
SHANG HAI XIAN DING Biotechnology Co., Ltd.	C1106-25g	4-(2-Chloroethyl)morpholine hydrochloride	3647-69-6	97.0%(T)	25g	￥150.0	2022-06-10
SHANG HAI XIAN DING Biotechnology Co., Ltd.	C1106-500g	4-(2-Chloroethyl)morpholine hydrochloride	3647-69-6	>97.0%(T)	500g	￥1,070.00	2021-05-19
SHANG HAI XIAN DING Biotechnology Co., Ltd.	C102A-5g	4-(2-Chloroethyl)morpholine hydrochloride	3647-69-6	98%	5g	￥48.0	2022-06-10
SHANG HAI XIAN DING Biotechnology Co., Ltd.	C102A-25g	4-(2-Chloroethyl)morpholine hydrochloride	3647-69-6	98%	25g	￥61.0	2022-06-10
SHANG HAI XIAN DING Biotechnology Co., Ltd.	C102A-100g	4-(2-Chloroethyl)morpholine hydrochloride	3647-69-6	98%	100g	￥131.0	2022-06-10
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	C133320-100g	4-(2-Chloroethyl)morpholine hydrochloride	3647-69-6	99%	100g	￥106.90	2023-09-03
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	C133320-2.5kg	4-(2-Chloroethyl)morpholine hydrochloride	3647-69-6	99%	2.5kg	￥1642.90	2023-09-03
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	C133320-25g	4-(2-Chloroethyl)morpholine hydrochloride	3647-69-6	99%	25g	￥41.90	2023-09-03
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	C133320-500g	4-(2-Chloroethyl)morpholine hydrochloride	3647-69-6	99%	500g	￥389.90	2023-09-03
YAN FENG KE JI （ BEI JING ） Co., Ltd.	H67259-25g	4-(2-Chloroethyl)morpholine hydrochloride	3647-69-6	99%	25g	￥48	2023-09-19

4-(2-Chloroethyl)morpholine hydrochloride Suppliers

Suzhou Senfeida Chemical Co., Ltd

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(CAS:3647-69-6)4-(2-Chloroethyl)morpholine hydrochloride

Order Number:sfd9067

Stock Status:in Stock

Quantity:200kg

Purity:99.9%

Pricing Information Last Updated:Friday, 19 July 2024 14:35

Price ($):discuss personally

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Product Official Link

Tiancheng Chemical (Jiangsu) Co., Ltd

Gold Member

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(CAS:3647-69-6)N-(2-氯乙基)嗎啉鹽酸鹽

Order Number:LE26128889

Stock Status:in Stock

Quantity:25KG,200KG,1000KG

Purity:99%

Pricing Information Last Updated:Friday, 20 June 2025 12:55

Price ($):discuss personally

Email:[email protected]

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Anna G. Cooper,Caitlin R. M. Oyagawa,Jamie J. Manning,Sameek Singh,Sarah Hook,Natasha L. Grimsey,Michelle Glass,Joel D. A. Tyndall,Andrea J. Vernall Med. Chem. Commun. 2018 9 2055
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Additional information on 4-(2-Chloroethyl)morpholine hydrochloride

4-(2-Chloroethyl)morpholine hydrochloride: A Comprehensive Overview

The compound with CAS No. 3647-69-6, commonly referred to as 4-(2-Chloroethyl)morpholine hydrochloride, is a significant entity in the field of organic chemistry. This compound has garnered attention due to its unique structural properties and potential applications in various industries. In this article, we will delve into its chemical structure, physical properties, synthesis methods, and recent advancements in its utilization across different sectors.

4-(2-Chloroethyl)morpholine hydrochloride is an organochlorine compound that belongs to the morpholine family. Morpholines are six-membered heterocyclic compounds consisting of an oxygen atom and a nitrogen atom in the ring structure. The presence of a chloroethyl group at the 4-position of the morpholine ring introduces unique reactivity and functional properties to this compound. The hydrochloride salt form indicates that the nitrogen atom in the morpholine ring is protonated, making it more water-soluble and easier to handle in various chemical reactions.

Recent studies have highlighted the importance of 4-(2-Chloroethyl)morpholine hydrochloride in medicinal chemistry. Researchers have explored its role as an intermediate in the synthesis of bioactive molecules, particularly in drug discovery programs targeting various therapeutic areas such as oncology, neurology, and infectious diseases. The chloroethyl group serves as a reactive site for further functionalization, enabling the construction of complex molecular architectures with desired pharmacokinetic profiles.

The synthesis of 4-(2-Chloroethyl)morpholine hydrochloride typically involves nucleophilic substitution reactions. Starting from morpholine, the introduction of a chloroethyl group can be achieved through alkylation using appropriate alkylating agents such as 1-chloro-2-bromoethane or similar compounds. The reaction conditions are optimized to ensure high yields and purity of the final product. The hydrochloride salt is often formed during the workup process by adjusting the pH to protonate the nitrogen atom.

In terms of physical properties, 4-(2-Chloroethyl)morpholine hydrochloride exhibits a melting point around 180°C and is soluble in polar solvents such as water and methanol. Its solubility characteristics make it suitable for use in various chemical processes, including chromatographic separations and crystallization studies. The compound is also relatively stable under normal storage conditions but should be protected from moisture and light to prevent degradation.

Recent advancements in green chemistry have led to innovative methods for synthesizing 4-(2-Chloroethyl)morpholine hydrochloride with reduced environmental impact. For instance, microwave-assisted synthesis has been employed to accelerate reaction rates and minimize energy consumption. Additionally, catalytic systems based on transition metals have been explored to enhance selectivity and reduce byproduct formation during the alkylation step.

The application of 4-(2-Chloroethyl)morpholine hydrochloride extends beyond medicinal chemistry. It has been utilized as a building block in polymer science for the development of novel materials with tailored mechanical and thermal properties. For example, researchers have incorporated this compound into polyurethane formulations to improve their resistance to environmental stressors such as UV radiation and temperature fluctuations.

In conclusion, 4-(2-Chloroethyl)morpholine hydrochloride (CAS No. 3647-69-6) is a versatile compound with significant potential in various fields of chemistry. Its unique structure, reactivity, and functional properties make it an invaluable tool for scientists and engineers alike. As research continues to uncover new applications and synthesis methods, this compound will undoubtedly play an increasingly important role in advancing modern chemical technologies.

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