• 1. An integrated immobilization strategy manipulates dual active centers to boost enantioselective tandem reactions
  Xiaomin Shu,Ronghua Jin,Zhongrui Zhao,Tanyu Cheng,Guohua Liu Chem. Commun. 2018 54 13244
• 2. Synthesis of thioethers, arenes and arylated benzoxazoles by transformation of the C(aryl)–C bond of aryl alcohols
  Mingyang Liu,Zhanrong Zhang,Bingfeng Chen,Qinglei Meng,Pei Zhang,Jinliang Song,Buxing Han Chem. Sci. 2020 11 7634
• 3. SO2F2 mediated dehydrative cross-coupling of alcohols with electron-deficient olefins in DMSO using a Pd-catalyst: one-pot transformation of alcohols into 1,3-dienes
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Biphenyls and derivatives
• Solvents and Organic Chemicals Organic Compounds Alcohol/Ether

Introduction to 1-(4-Biphenylyl)ethanol (CAS No. 3562-73-0)

1-(4-Biphenylyl)ethanol, identified by its Chemical Abstracts Service (CAS) number 3562-73-0, is a significant organic compound with a molecular structure that combines a biphenyl moiety with an ethanol side chain. This unique arrangement imparts distinct chemical and pharmacological properties, making it a subject of interest in various fields, particularly in medicinal chemistry and material science. The biphenyl ring, known for its stability and aromaticity, interacts synergistically with the hydroxyl group of ethanol, creating a versatile scaffold for further functionalization.

The compound’s structure consists of a phenyl ring substituted at the 4-position with another phenyl ring, linked to an ethyl chain terminated by a hydroxyl (-OH) group. This configuration allows for multiple sites of chemical modification, enabling the synthesis of derivatives with tailored properties. In recent years, the exploration of biphenyl-based compounds has surged due to their potential applications in drug development and advanced materials.

1-(4-Biphenylyl)ethanol has garnered attention in the pharmaceutical industry for its potential as an intermediate in the synthesis of biologically active molecules. The biphenyl moiety is frequently encountered in pharmacophores due to its ability to enhance binding affinity and metabolic stability. Researchers have leveraged this scaffold to develop novel therapeutic agents targeting various diseases, including neurological disorders and cancer.

One of the most compelling aspects of 1-(4-Biphenylyl)ethanol is its role in the development of small-molecule probes for biochemical studies. The compound’s dual functionality—aromaticity from the biphenyl ring and reactivity from the hydroxyl group—makes it an excellent candidate for designing tools that interact with biological targets. For instance, it has been used in the synthesis of fluorescent probes that facilitate high-resolution imaging of cellular processes.

Recent advancements in computational chemistry have further highlighted the significance of 1-(4-Biphenylyl)ethanol. Molecular modeling studies indicate that this compound can serve as a precursor for ligands that modulate enzyme activity. Specifically, researchers have demonstrated its utility in developing inhibitors for enzymes involved in inflammatory pathways. These findings align with ongoing efforts to discover safer and more effective anti-inflammatory drugs.

The material science applications of 1-(4-Biphenylyl)ethanol are equally noteworthy. Its ability to form stable complexes with metal ions has been exploited in the design of catalysts and coordination polymers. Such materials are crucial for sustainable chemistry, enabling more efficient reactions under milder conditions. Additionally, the compound’s solubility profile makes it suitable for use in organic electronic devices, where precise molecular arrangement is essential for optimal performance.

1-(4-Biphenylyl)ethanol also plays a role in synthetic organic chemistry as a building block for more complex molecules. Its versatility allows chemists to introduce diverse functional groups while maintaining structural integrity. This flexibility has been particularly valuable in the synthesis of heterocyclic compounds, which are prevalent in many pharmaceuticals and agrochemicals.

In conclusion, 1-(4-Biphenylyl)ethanol (CAS No. 3562-73-0) represents a multifaceted compound with broad applications across multiple scientific disciplines. Its unique structural features make it an invaluable asset in drug discovery, biochemical research, and material engineering. As our understanding of molecular interactions deepens, the potential uses for this compound are likely to expand even further.

• 90162-45-1((±)-1-Phenyl-d5-ethanol)
• 1013027-15-0(1-[3-(Hydroxymethyl)phenyl]ethanol)
• 54225-75-1((1R)-1-(4-ethylphenyl)ethan-1-ol)
• 3101-96-0((±)-1-Phenylethan-1-d1-ol)
• 53172-57-9([1,1'-Biphenyl]-4,4'-dimethanol,a4,a4'-diphenyl-)
• 5379-18-0(Benzenemethanol, a,3,5-trimethyl-)
• 128599-36-0(ETHYLIUM, 1-HYDROXY-1-(3-METHYLPHENYL)-)
• 90162-44-0((±)-1-Phenylethan-1,2,2,2-d4-ol)
• 34352-74-4(2-(4-phenylphenyl)propan-2-ol)
• 7598-80-3(1,\u200b1'-\u200bBiphenyl\u200b-\u200b4-\u200byl(phenyl)\u200bmethanol)