• 1. Quantitative investigation of the decomposition of organic lithium ion battery electrolytes with LC-MS/MS
  Carola Schultz,Sven Vedder,Benjamin Streipert,Martin Winter,Sascha Nowak RSC Adv. 2017 7 27853

• Solvents and Organic Chemicals Organic Compounds Acids/Esters

Recent Advances in the Study of 2-Ethoxycarbonyloxyethyl Ethyl Carbonate (CAS: 35466-87-6) in Chemical Biology and Pharmaceutical Research

2-Ethoxycarbonyloxyethyl Ethyl Carbonate (CAS: 35466-87-6) is a chemical compound that has garnered significant attention in recent years due to its potential applications in drug delivery systems and pharmaceutical formulations. This compound, characterized by its carbonate ester structure, has been explored for its ability to enhance the solubility and bioavailability of poorly water-soluble drugs. Recent studies have focused on its role as a prodrug moiety and its utility in controlled-release formulations, making it a promising candidate for innovative therapeutic strategies.

One of the key areas of research involving 2-Ethoxycarbonyloxyethyl Ethyl Carbonate is its application in prodrug design. Prodrugs are pharmacologically inactive compounds that are metabolized in the body to release the active drug. The carbonate ester linkage in this compound provides a stable yet cleavable bond, which can be hydrolyzed by esterases in vivo to release the parent drug. Recent studies have demonstrated its effectiveness in improving the pharmacokinetic profiles of various anticancer and antiviral agents, thereby enhancing their therapeutic efficacy while minimizing side effects.

In addition to its prodrug applications, 2-Ethoxycarbonyloxyethyl Ethyl Carbonate has been investigated for its role in nanotechnology-based drug delivery systems. Researchers have utilized this compound to modify the surface properties of nanoparticles, thereby improving their stability and targeting efficiency. For instance, a recent study published in the Journal of Controlled Release highlighted its use in the development of polymeric nanoparticles for targeted delivery of chemotherapeutic agents to tumor sites. The study reported a significant reduction in systemic toxicity and improved tumor accumulation, underscoring the compound's potential in cancer therapy.

Another notable advancement is the exploration of 2-Ethoxycarbonyloxyethyl Ethyl Carbonate in the formulation of biodegradable polymers. These polymers are designed to degrade under physiological conditions, releasing the encapsulated drug in a controlled manner. A study in Biomaterials Science demonstrated that incorporating this compound into polymer matrices resulted in tunable degradation rates and sustained drug release profiles, making it highly suitable for long-term therapeutic applications such as chronic pain management and hormone replacement therapy.

Despite these promising developments, challenges remain in the widespread adoption of 2-Ethoxycarbonyloxyethyl Ethyl Carbonate. Issues such as scalability of synthesis, reproducibility of formulations, and regulatory approval hurdles need to be addressed. However, ongoing research efforts are focused on optimizing synthetic routes and conducting comprehensive preclinical studies to validate its safety and efficacy. Collaborative initiatives between academia and industry are expected to accelerate the translation of these findings into clinically viable products.

In conclusion, 2-Ethoxycarbonyloxyethyl Ethyl Carbonate (CAS: 35466-87-6) represents a versatile and promising compound in the field of chemical biology and pharmaceutical research. Its applications in prodrug design, nanotechnology, and biodegradable polymers highlight its potential to address critical challenges in drug delivery and formulation. As research continues to uncover new insights, this compound is poised to play a pivotal role in the development of next-generation therapeutics.

• 96-49-1(Ethylene Carbonate)
• 35466-86-5(Carbonic acid,2-methoxyethyl methyl ester)
• 106729-72-0(Carbonic acid, 2-hydroxyethyl methyl ester)
• 362049-63-6(1,3-Dioxolan-2-one-d4)
• 76425-92-8(2,5,8,10,13-Pentaoxapentadecanoicacid, 9-oxo-, 2-ethoxyethyl ester)
• 626-84-6(ethanol, 2-methoxy-, carbonate (2:1))
• 141814-27-9(2-(2-methoxyethoxy)ethyl methyl carbonate)
• 2049-74-3(bis(2-ethoxyethyl) carbonate)
• 6947-11-1(2-(2-ethoxycarbonyloxyethoxy)ethyl Ethyl Carbonate)
• 88754-66-9(2,5-Dioxahexanedioic Acid Dimethyl Ester)