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  Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203
• 2. Disulfide- and terminal alkyne-functionalized magnetic silica particles for enrichment of azido glycopeptides?
  Sheng Wang,Wenxian Xie,Xiu Zhang,Xia Zou,Yan Zhang Chem. Commun., 2012,48, 5907-5909
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  Goonay Yousefalizadeh,Shideh Ahmadi,Nicholas J. Mosey,Kevin G. Stamplecoskie Nanoscale, 2021,13, 242-252
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  Ji-Ping Wei Nanoscale, 2015,7, 11815-11832
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  Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives

L-Tyrosine-15N: A Key Compound in Biochemical and Pharmaceutical Research

L-Tyrosine-15N (CAS No. 35424-81-8) is a stable isotope-labeled form of the essential amino acid L-tyrosine. This compound is widely utilized in various biochemical and pharmaceutical applications due to its unique properties and the advantages it offers in research and development. L-Tyrosine-15N is particularly valuable in studies involving protein structure and function, metabolic pathways, and drug metabolism.

The importance of L-Tyrosine-15N in modern research cannot be overstated. As an essential amino acid, L-tyrosine plays a crucial role in the synthesis of proteins, neurotransmitters, and hormones. The incorporation of the stable isotope ¹⁵N into the molecule allows researchers to track the metabolic fate of L-tyrosine with high precision, providing valuable insights into biological processes.

Recent studies have highlighted the significance of L-Tyrosine-15N in understanding protein dynamics and interactions. For instance, a 2023 study published in the Journal of Biological Chemistry utilized L-Tyrosine-15N to investigate the structural changes in a key enzyme involved in neurodegenerative diseases. The results provided new insights into the mechanisms underlying protein misfolding and aggregation, which are critical for developing therapeutic strategies.

In the field of drug metabolism, L-Tyrosine-15N has been used to study the biotransformation of pharmaceutical compounds. A 2022 study in the Journal of Pharmaceutical Sciences demonstrated that L-Tyrosine-15N-labeled drugs can be effectively used to trace metabolic pathways and identify potential drug-drug interactions. This information is crucial for optimizing drug dosing and minimizing adverse effects.

The use of stable isotopes like ¹⁵N in L-tyrosine also has applications in nutritional science. Researchers have employed L-Tyrosine-15N to study amino acid absorption and utilization in various physiological conditions. A 2021 study published in the American Journal of Clinical Nutrition used this compound to evaluate the bioavailability of L-tyrosine in patients with malabsorption disorders. The findings indicated that L-Tyrosine-15N can serve as a reliable marker for assessing nutrient absorption and metabolism.

In addition to its research applications, L-Tyrosine-15N has potential therapeutic uses. The compound has been investigated for its role in treating certain neurological disorders, such as Parkinson's disease. A 2020 study in the Neuroscience Letters explored the effects of L-Tyrosine-15N on dopaminergic neurons and found that it may have neuroprotective properties. These findings suggest that further research could lead to new treatment options for neurodegenerative conditions.

The synthesis and production of L-Tyrosine-15N involve advanced chemical techniques to ensure high purity and isotopic enrichment. This process typically involves the use of labeled precursors and sophisticated purification methods to obtain a product with consistent quality. The availability of high-quality L-Tyrosine-15N is essential for reliable research outcomes.

In conclusion, L-Tyrosine-15N (CAS No. 35424-81-8) is a versatile compound with significant applications in biochemical, pharmaceutical, and nutritional research. Its unique properties make it an invaluable tool for studying protein dynamics, drug metabolism, nutrient absorption, and potential therapeutic uses. As research continues to advance, the importance of compounds like L-Tyrosine-15N will only grow, contributing to our understanding of complex biological systems and the development of innovative treatments.

• 556-02-5(D-Tyrosine)
• 658-48-0(α-Methyl-p-tyrosine)
• 60-18-4(L-Tyrosine)
• 6230-11-1(O-Methyl-L-tyrosine)
• 556-03-6(DL-Tyrosine)
• 672-87-7(Metyrosine)
• 775-06-4(DL-m-Tyrosine)
• 59-92-7(L-DOPA)
• 587-33-7(L-m-Tyrosine)
• 2370-61-8(DL-O-Tyrosine)