Production Method 1

3524-73-0

7642-10-6

1113-56-0

2532-58-3

28823-41-8

287-92-3

816-79-5

108-87-2

1759-58-6

17618-77-8

7459-71-4

14686-13-6

14686-14-7

2146-38-5

6443-92-1

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Ruthenium phosphide (RuP2) ,  Molybdenum phosphide (MoP) ,  Silica Gel 60 ;  2 h, 600 °C; 600 °C → 450 °C; 15 min, 450 °C
1.2 Reagents: Hydrogen ;  9 h, 100 mbar, 450 °C

Reference

A Highly Stable Bimetallic Transition Metal Phosphide Catalyst for Selective Dehydrogenation of n-Heptane

Stober, Robert; et al, ChemCatChem, 2022, 14(18),

5-Methyl-1-hexene Preparation Products

• (3Z)-3-Heptene (7642-10-6)
• 2,3-dimethyl-1,3-pentadiene (1113-56-0)
• Cyclopentane,1,3-dimethyl-, (1R,3S)-rel- (2532-58-3)
• 2,4-Hexadiene,2-methyl- (28823-41-8)
• Cyclopentane (287-92-3)
• 2-Pentene, 3-ethyl- (816-79-5)
• Methylcyclohexane (108-87-2)
• trans-1,3-Dimethylcyclopentane (~70%) (1759-58-6)
• 2-Hexene, 3-methyl- (17618-77-8)
• 3,5-dimethylcyclopentene (7459-71-4)
• 2-Heptene, (2E)- (14686-13-6)
• trans-3-Heptene (14686-14-7)
• 1-Ethyl-1-cyclopentene (2146-38-5)
• 5-Methyl-1-hexene (3524-73-0)
• (Z)-2-Heptene (6443-92-1)

• 1. Studies on the sharpless asymmetric epoxidation of unsymmetrical divinylmethanols
  Toshio Honda,Hirotake Mizutani,Kazuo Kanai J. Chem. Soc. Perkin Trans. 1 1996 1729
• 2. Linear free-energy relationships for water/hexadec-1-ene and water/deca-1,9-diene partitions, and for permeation through lipid bilayers; comparison of permeation systems
  Michael H. Abraham,William E. Acree New J. Chem. 2012 36 1798
• 3. Effective 1,5-, 1,6- and 1,7-remote stereocontrol in reactions of alkoxy- and hydroxy-substituted allylstannanes with aldehydes
  John S. Carey,Somhairle MacCormick,Steven J. Stanway,Aphiwat Teerawutgulrag,Eric J. Thomas Org. Biomol. Chem. 2011 9 3896
• 4. Effective 1,5-, 1,6- and 1,7-remote stereocontrol in reactions of alkoxy- and hydroxy-substituted allylstannanes with aldehydes
  John S. Carey,Somhairle MacCormick,Steven J. Stanway,Aphiwat Teerawutgulrag,Eric J. Thomas Org. Biomol. Chem. 2011 9 3896
• 5. Three decades of disparlure and analogue synthesis
  Rodney A. Fernandes,Naveen Chandra,Ashvin J. Gangani New J. Chem. 2020 44 17616

• Solvents and Organic Chemicals Organic Compounds Hydrocarbons Unsaturated hydrocarbons Unsaturated aliphatic hydrocarbons
• Solvents and Organic Chemicals Organic Compounds Acids/Esters
• Solvents and Organic Chemicals Organic Compounds Hydrocarbons

Introduction to 5-Methyl-1-hexene (CAS No. 3524-73-0)

5-Methyl-1-hexene, with the chemical formula C7H14, is an important alkene compound characterized by a branched structure featuring a methyl group on the fifth carbon atom of the hexene chain. This compound, identified by its unique Chemical Abstracts Service (CAS) number 3524-73-0, has garnered significant attention in the field of organic synthesis and industrial applications due to its versatile reactivity and structural properties. As a key intermediate in petrochemical and fine chemical manufacturing, 5-Methyl-1-hexene plays a pivotal role in the production of polymers, fragrances, and pharmaceuticals.

The molecular structure of 5-Methyl-1-hexene consists of a linear hexene backbone with a methyl substituent at the fifth carbon position. This branching imparts distinct physical and chemical properties, making it a valuable building block for various synthetic pathways. The compound exhibits typical alkenic characteristics, including the presence of a carbon-carbon double bond (C=C) that is highly reactive in processes such as polymerization, hydrogenation, and functionalization. Its boiling point, solubility in organic solvents, and thermal stability make it suitable for use in high-purity chemical applications.

In recent years, research into 5-Methyl-1-hexene has been closely linked to advancements in catalytic processes and green chemistry. One notable area of study involves the development of efficient catalytic systems for the selective polymerization of this compound into high-value polyolefins. For instance, recent studies have demonstrated the use of transition metal catalysts, such as zirconocenes and nickel complexes, to produce polymers with tailored molecular weights and distributions. These developments not only enhance the efficiency of polymer production but also contribute to sustainable manufacturing practices by reducing waste and energy consumption.

Moreover, 5-Methyl-1-hexene has found applications in the synthesis of specialty chemicals, including fragrances and pharmaceutical intermediates. Its branched structure allows for diverse functionalization strategies, enabling the introduction of various substituents at different positions along the carbon chain. This flexibility is particularly valuable in pharmaceutical research, where precise molecular architecture is often critical for drug efficacy and bioavailability. For example, derivatives of 5-Methyl-1-hexene have been explored as precursors to nonsteroidal anti-inflammatory drugs (NSAIDs) and other therapeutic agents.

The industrial production of 5-Methyl-1-hexene typically involves olefin isomerization and cracking processes derived from petroleum refining or bio-based feedstocks. Advances in process optimization have led to more efficient methods for isolating and purifying this compound, ensuring high yields and minimal byproduct formation. Additionally, research into biocatalytic routes has opened new avenues for sustainable production, leveraging enzymatic or microbial systems to generate 5-Methyl-1-hexene from renewable resources.

Recent breakthroughs in computational chemistry have further enhanced our understanding of 5-Methyl-1-hexene's reactivity and potential applications. Molecular modeling studies have identified novel reaction pathways and catalyst systems that could improve its utility in industrial processes. These computational approaches are complemented by experimental investigations into novel derivatives and reaction conditions, pushing the boundaries of what is possible with this versatile compound.

The safety and handling of 5-Methyl-1-hexene are also areas of ongoing research. While it is not classified as a hazardous material under standard regulatory frameworks, proper precautions must be taken to ensure safe handling during storage, transportation, and application. Studies have focused on developing effective containment systems and spill management protocols to mitigate potential risks associated with large-scale industrial use.

In conclusion,5-Methyl-1-hexene (CAS No. 3524-73-0) remains a cornerstone in organic synthesis and industrial chemistry due to its unique structural properties and wide range of applications. From polymer production to pharmaceutical intermediates,5-Methyl-1-hexene continues to be a subject of intense research interest as scientists explore new ways to harness its potential for advanced materials and therapeutic agents. The ongoing development of innovative catalytic systems,green chemistry approaches,and computational methodologies ensures that this compound will remain relevant in shaping future advancements across multiple scientific disciplines.

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