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  Shun-Ze Zhan,Mian Li,Xiao-Ping Zhou,Dan Li,Seik Weng Ng RSC Adv., 2011,1, 1457-1459
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  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693
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  Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991
• 4. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzothiophenes 1-benzothiophenes

Comprehensive Overview of OGG1-IN-08 (CAS No. 350997-39-6): A Potent Inhibitor Targeting DNA Repair Mechanisms

In the rapidly evolving field of molecular biology and oncology research, OGG1-IN-08 (CAS No. 350997-39-6) has emerged as a pivotal compound for studying DNA repair pathways. This small-molecule inhibitor specifically targets 8-oxoguanine DNA glycosylase 1 (OGG1), an enzyme critical for base excision repair (BER) of oxidative DNA damage. With rising interest in cancer therapeutics and genomic stability, researchers are increasingly exploring OGG1 inhibitors like OGG1-IN-08 to disrupt tumor survival mechanisms and enhance the efficacy of existing treatments such as chemotherapy and radiation therapy.

The molecular structure of OGG1-IN-08 (CAS No. 350997-39-6) is optimized for high selectivity and potency, making it a valuable tool for biochemical assays and cell-based studies. Recent publications highlight its role in modulating oxidative stress responses, a hot topic linked to aging, neurodegenerative diseases, and cancer progression. Users searching for "OGG1 inhibitor mechanism" or "how to block DNA repair in cancer cells" will find this compound particularly relevant, as it addresses these queries through its well-documented action on OGG1 enzyme inhibition.

From a technical perspective, OGG1-IN-08 exhibits low cytotoxicity in normal cells while selectively impairing cancer cell proliferation, a feature that aligns with the growing demand for targeted cancer therapies. Its IC50 values and binding affinity data are frequently cited in discussions about precision medicine, another trending topic in biomedical research. Laboratories focusing on DNA damage response (DDR) pathways often utilize this compound to investigate synthetic lethality strategies, a concept gaining traction in personalized oncology.

Beyond oncology, OGG1-IN-08 (CAS No. 350997-39-6) is also employed in studies related to chronic inflammation and metabolic disorders, where oxidative DNA damage plays a key role. This versatility answers common search queries like "OGG1 inhibitor applications" and "link between DNA repair and inflammation." The compound’s stability under physiological conditions further enhances its utility in in vivo models, a feature highlighted in recent peer-reviewed journals.

In summary, OGG1-IN-08 represents a cutting-edge research reagent with multifaceted applications in drug discovery and mechanistic studies. Its association with high-impact areas such as cancer metabolism, genomic integrity, and therapeutic resistance ensures its continued relevance in scientific literature. For researchers seeking to explore OGG1-dependent pathways or develop combinatorial treatment regimens, this inhibitor offers a robust and well-characterized solution.

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