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• 2. An integrated chip for immunofluorescence and its application to analyze lysosomal storage disorders
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• 3. An artificial enzyme cascade amplification strategy for highly sensitive and specific detection of breast cancer-derived exosomes?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Halopyrimidines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyrimidines and pyrimidine derivatives Halopyrimidines

Recent Advances in the Application of (2-chloropyrimidin-4-yl)methanol (CAS: 34953-87-2) in Chemical Biology and Pharmaceutical Research

The compound (2-chloropyrimidin-4-yl)methanol (CAS: 34953-87-2) has recently garnered significant attention in chemical biology and pharmaceutical research due to its versatile applications as a key intermediate in the synthesis of bioactive molecules. This research brief aims to provide an up-to-date overview of the latest findings and developments related to this compound, focusing on its synthetic utility, biological activities, and potential therapeutic applications.

Recent studies have highlighted the importance of (2-chloropyrimidin-4-yl)methanol as a building block for the development of novel kinase inhibitors. A 2023 publication in the Journal of Medicinal Chemistry demonstrated its use in the synthesis of selective JAK2 inhibitors, showing promising results in preclinical models of myeloproliferative disorders. The compound's chlorine and hydroxyl functional groups provide excellent handles for further derivatization, enabling the creation of diverse molecular architectures with tailored biological properties.

In the field of antibacterial drug discovery, researchers have utilized (2-chloropyrimidin-4-yl)methanol to develop novel compounds targeting bacterial DNA gyrase. A recent study published in Bioorganic & Medicinal Chemistry Letters reported a series of pyrimidine derivatives synthesized from this intermediate that exhibited potent activity against drug-resistant Staphylococcus aureus strains. The structural flexibility of the compound allowed for optimization of both antibacterial potency and pharmacokinetic properties.

Significant progress has also been made in understanding the compound's reactivity and stability under various conditions. A 2024 computational study published in the Journal of Organic Chemistry provided detailed insights into the compound's preferred reaction pathways and potential side reactions, which is crucial for its effective utilization in multistep syntheses. These findings have important implications for process chemistry and scale-up production of pharmaceutical candidates derived from this intermediate.

From a safety and toxicological perspective, recent investigations have confirmed the compound's favorable profile when handled under standard laboratory conditions. However, researchers emphasize the importance of proper protective measures due to its potential skin and eye irritation properties. Several pharmaceutical companies have included (2-chloropyrimidin-4-yl)methanol in their compound libraries for high-throughput screening campaigns, recognizing its value in hit-to-lead optimization programs.

Looking forward, the compound continues to be of great interest in drug discovery, particularly in the development of targeted therapies for cancer and infectious diseases. Ongoing research is exploring its potential in PROTAC (Proteolysis Targeting Chimera) technology and other emerging therapeutic modalities. The versatility of (2-chloropyrimidin-4-yl)methanol ensures its continued relevance in medicinal chemistry and chemical biology research in the coming years.

• 1289385-59-6(2-CHLORO-4-ETHOXYMETHYL-PYRIMIDINE)
• 149849-92-3(2-Chloropyrimidine-4-carboxylic acid)
• 1008780-47-9(2-Chloro-4,6-Pyrimidinedicarboxylic acid)
• 181363-21-3(4-Pyrimidinemethanol, 2-chloro-6-methyl-)
• 89581-58-8(2-Chloro-6-methyl-pyrimidine-4-carboxylic acid)
• 1312535-79-7(1-(2-Chloropyrimidin-4-yl)ethanol)
• 13036-57-2(2-Chloro-4-methylpyrimidine)
• 149849-95-6(2-Chloropyrimidine-4-carboxylic acid)
• 33581-98-5(pyrimidin-4-ylmethanol)
• 1289387-30-9(2-Chloro-4-(methoxymethyl)pyrimidine)