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• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Prenol lipids Retinoids

13-cis-Retinyl Acetate (85%)

13-cis-Retinyl Acetate is a derivative of retinol, a form of vitamin A, and is widely used in various fields due to its unique properties. With the CAS number 34356-31-5, this compound has gained significant attention in recent years for its applications in dermatology, oncology, and ophthalmology. The 85% purity of this product ensures its effectiveness in research and therapeutic settings.

The structure of 13-cis-Retinyl Acetate is characterized by a cis configuration at the 13th carbon of the retinol backbone. This specific stereochemistry plays a crucial role in its biological activity. Recent studies have shown that this compound exhibits potent anti-inflammatory and anti-proliferative effects, making it a promising candidate for treating conditions such as acne, psoriasis, and certain types of cancer.

In dermatology, 13-cis-Retinyl Acetate has been extensively studied for its ability to regulate keratinocyte differentiation and reduce sebum production. Clinical trials have demonstrated its efficacy in reducing acne vulgaris severity by modulating lipid metabolism and inhibiting bacterial growth. Furthermore, its anti-inflammatory properties make it a potential treatment for inflammatory skin disorders.

Recent advancements in cancer research have highlighted the role of 13-cis-Retinyl Acetate in inducing apoptosis in cancer cells. Studies conducted on melanoma and breast cancer cell lines have shown that this compound can selectively target malignant cells while sparing healthy tissue. This selective cytotoxicity underscores its potential as a targeted therapy in oncology.

The synthesis of 13-cis-Retinyl Acetate involves a multi-step process that includes the isolation of retinol from natural sources or synthetic routes, followed by esterification with acetic acid. The stereochemistry at the 13th carbon is critical, and modern techniques such as high-performance liquid chromatography (HPLC) are employed to ensure the desired cis configuration is maintained during synthesis.

In terms of bioavailability, 13-cis-Retinyl Acetate is well-absorbed when administered topically or orally. Its lipophilic nature allows it to penetrate cellular membranes effectively, facilitating its transport to target sites. However, excessive intake can lead to hypervitaminosis A, emphasizing the importance of proper dosing and monitoring during clinical use.

From an environmental perspective, 13-cis-Retinyl Acetate is biodegradable under aerobic conditions, making it an eco-friendly option for pharmaceutical applications. Its degradation products are non-toxic and do not pose significant risks to aquatic life, aligning with current sustainability goals in drug development.

In conclusion, 13-cis-Retinyl Acetate (85%) is a versatile compound with a wide range of applications in medicine and research. Its unique stereochemistry, coupled with its potent biological effects, positions it as a valuable tool in addressing various health challenges. As ongoing research continues to uncover new insights into its mechanisms of action, this compound is poised to play an even greater role in therapeutic development.

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